Sickle cell disease trials in United States

In United States 133 Also abroad 204

133 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Genotype -Phenotype Correlation of PKLR Variants With Pyruvate Kinase, 2,3-Diphosphglycerate and Adenosine Triphosphate Activities in Red Blood Cells of People With Sickle Cell Disease
Where
Bethesda
Age
18 years to 80 years
People
800
Run by
National Heart, Lung, and Blood Institute (NHLBI)
See details and how to joinNCT03685721
Phase 3Taking people
A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)
Where
Augusta, Baltimore, Birmingham, Chicago, Easton, Flowood, Greenville, Houston, Jacksonville, Louisville, Orange, Philadelphia, Riverdale, The Bronx, Washington D.C., Winston-Salem
Age
12 years to 100 years
People
354 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT06439082
No phaseNot yet taking people in United States
Mechanisms Within the Autonomic Nervous SysTEm undeRlying MusIc Therapy's aNalgesic Effects in Sickle Cell Disease (MASTERMIND)
Where
Cleveland
Age
18 years and over
People
10
Run by
University Hospitals Cleveland Medical Center
See details and how to joinNCT07928089
No phaseTaking people
Natural History of Sickle Cell Disease
Where
Bethesda, Washington D.C.
Age
2 years to 90 years
People
3,500
Run by
National Heart, Lung, and Blood Institute (NHLBI)
See details and how to joinNCT00081523
No phaseTaking people
HPC Offered for PRESERVE Expansion
Where
Birmingham, Columbus, Detroit, Duarte, Nashville
Age
12 years to 80 years
People
10
Run by
Ossium Health, Inc.
See details and how to joinNCT07145411
Phase 1Taking people
Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in Subjects With Stable Sickle Cell Disease
Where
Bethesda
Age
18 years to 65 years
People
35
Run by
National Heart, Lung, and Blood Institute (NHLBI)
See details and how to joinNCT05904093
Phase 4Taking people
Clinical and Biomarker Effects of Depot Medroxyprogesterone Acetate in Females With Sickle Cell Disease
Where
Atlanta, Philadelphia
Age
18 years to 50 years
People
65
Run by
University of Pennsylvania
See details and how to joinNCT06665997
Phase 1Not yet taking people in United States
Buprenorphine for the Management of Pain in Children With Sickle Cell Disease
Where
Boston
Age
12 years to 22 years
People
25
Run by
Natasha Archer
See details and how to joinNCT07799571
Phase 2Taking people
Safety of Anumigilimab (CSL324) in Adults With Sickle Cell Disease (SCD)
Where
Atlanta, Bethesda, Boston, Columbus, Flowood, Hollywood, Houston, Jamaica, Little Rock, Minneapolis, New York, Orange, Richmond, The Bronx
Age
18 years and over
People
63 worldwide
Run by
CSL Behring
See details and how to joinNCT07224360 · EU 2025-521154-42-00
No phaseNot yet taking people in United States
Data Collection For Patients With Sickle Cell Disease
Where
Houston
Age
18 years and over
People
500
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT07911618
No phaseNot yet taking people in United States
Hypoxic Red Blood Cells in Sickle Cell Anemia
Where
Atlanta, Baltimore, Chicago, Farmington, Pittsburgh
Age
7 years and over
People
48
Run by
Hemanext
See details and how to joinNCT06743113
No phaseNot yet taking people in United States
Focused Ultrasound Neuromodulation for Chronic Pain
Where
Minneapolis
Age
18 years and over
People
80
Run by
University of Minnesota
See details and how to joinNCT07910396
Phase 3Taking people
A Study to Investigate the Effect of Mitapivat on Transfusion Burden in Subjects With Sickle Cell Disease (SCD)
Where
Flowood, Grand Rapids, Houston, Indianapolis, New York
Age
12 years and over
People
159 worldwide
Run by
Agios Pharmaceuticals, Inc.
See details and how to joinNCT07656415 · EU 2026-526778-18-00
Phase 1/2Taking people
A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell Disease
Where
Birmingham, Boston, Charlotte, Greenville, Houston, Miami, New York, Philadelphia, Providence
Age
12 years to 55 years
People
161 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT06546670 · EU 2024-515696-35-00
No phaseEnrolling by invitation
Blood Collection for Research Related to Certain Diseases Involving Blood Vessels
Where
Bethesda, Fairfax
Age
18 years to 100 years
People
2,000
Run by
National Heart, Lung, and Blood Institute (NHLBI)
See details and how to joinNCT00047996
No phaseTaking people
Blood Sampling for Research Related to Sickle Cell Disease
Where
Bethesda
Age
18 years to 100 years
People
250
Run by
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
See details and how to joinNCT00542230
Phase 1/2Taking people
Repeat Peripheral Blood Stem Cell Transplantation for Patients With Sickle Cell Disease and Falling Donor Myeloid Chimerism Levels
Where
Bethesda
Age
2 years to 80 years
People
32
Run by
National Heart, Lung, and Blood Institute (NHLBI)
See details and how to joinNCT04008368
Phase 2Taking people
AlloSCT for Malignant and Non-malignant Hematologic Diseases Utilizing Alpha/Beta T Cell and CD19+ B Cell Depletion
Where
Valhalla
Age
1 day to 30 years
People
20
Run by
Mitchell Cairo
See details and how to joinNCT04099966
No phaseTaking people
Observational Study to Deeply Phenotype Major Organs in Sickle Cell Disease After Curative Therapies
Where
Bethesda
Age
18 years to 100 years
People
200
Run by
National Heart, Lung, and Blood Institute (NHLBI)
See details and how to joinNCT05213572
No phaseTaking people
Trans-auricular Nerve Stimulation as an Innovative Approach to the Treatment of Pain in Pediatric Patients Suffering From Sickle Cell Disease
Where
Atlanta
Age
7 years to 18 years
People
20
Run by
Emory University
See details and how to joinNCT07090668
Phase 1Taking people
Escalating Doses of VAS-101 in Subjects With Stable Sickle Cell Disease
Where
Bethesda
Age
18 years to 90 years
People
25
Run by
National Heart, Lung, and Blood Institute (NHLBI)
See details and how to joinNCT07566494
Phase 1Taking people
Hematopoietic Stem Cell BCL11A Enhancer Gene Editing for Sickle Cell Disease
Where
Boston
Age
13 years to 35 years
People
5
Run by
Daniel Bauer
See details and how to joinNCT07708350
Phase 1/2Taking people
Transplantation of Clustered Regularly Interspaced Short Palindromic Repeats Modified Hematopoietic Progenitor Stem Cells (CRISPR_SCD001) in Patients With Severe Sickle Cell Disease
Where
Davis, Los Angeles, Oakland
Age
12 years to 35 years
People
9
Run by
Mark Walters, MD
See details and how to joinNCT04774536
No phaseTaking people
Virtual Reality for SCD VOC
Where
Baltimore
Age
18 years to 88 years
People
50
Run by
University of Maryland, Baltimore
See details and how to joinNCT07674277
Phase 1Taking people
Gene Editing For Sickle Cell Disease
Where
Memphis
Age
18 years to 24 years
People
25
Run by
St. Jude Children's Research Hospital
See details and how to joinNCT06506461