Tests a magnetic brain stimulation method for people with depression
Tests repeated magnetic brain stimulation at personalized frequencies in adults with major depressive disorder.
Plain-language title generated from the registry record
Registry title: Spectral TMS (s-TMS)
Key facts
- Where
- Los Angeles, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT04040062, who can take part
Where in United States
- University of CaliforniaLos Angeles, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of California, Los Angeles
- Trial code
- NCT04040062
- Record updated
- 18 March 2026
- Original description
This study will analyze the feasibility, safety, and tolerability of administering repetitive Transcranial magnetic stimulation(TMS) at frequencies other than standard 10 Hz. This study will enroll 50 subjects who will undergo one quantitative electroencephalograph, one TMS procedure to determine the appropriate frequency and intensity for treatment, weekly mood/symptom assessments, and up to 30 TMS treatments. Subjects will be asked to participate for up to 6 weeks.Read full original descriptionShow less
Pilot Study: Evaluating the Feasibility of Repetitive Transcranial Magnetic Stimulation Treatment Delivered at Individual-based, SCC-determined Frequency in Subjects Suffering From Major Depressive Disorder
This study will analyze the feasibility, safety, and tolerability of administering repetitive Transcranial magnetic stimulation(TMS) at frequencies other than standard 10 Hz. This study will enroll 50 subjects who will undergo one quantitative electroencephalograph, one TMS procedure to determine the appropriate frequency and intensity for treatment, weekly mood/symptom assessments, and up to 30 TMS treatments. Subjects will be asked to participate for up to 6 weeks.
Inclusion: All subjects must be over between 18-65 years of age; Must have confirmed diagnosis of severe Major Depressive Disorder (single or recurrent episode); Failure to respond to a minimum of 4 trials of antidepressant medication; Failure to respond from at least two different agent classes; Accompanied by at least two evidence-based augmentation therapies (Benzodiazepines do not count); Must have a trial of psychotherapy known to be effective in the treatment of MDD of an adequate frequency and duration; Subjects are willing and able to adhere to the treatment schedule and required study visits.
Exclusion: Presence of an implanted magnetic-sensitive medical device located less than or equal to 30 centimeters from the transcranial magnetic stimulation magnetic coil or other implanted metal items, including but not limited to a cochlear implant, implanted cardioverter defibrillator, pacemaker, vagus nerve stimulator, or metal aneurysm clips or coils, staples, or stents; (Note: Dental amalgam fillings are not affected by the magnetic field and are acceptable for use with transcranial magnetic stimulation; Have an infection or poor skin condition over the scalp where the device will be positioned; Have increased risk of seizure because of family history, stroke, or currently use medications that lead to increased risk for seizure; Diagnosis of acute or chronic psychotic symptoms or disorders (such as schizophrenia, schizophreniform or schizoaffective disorder) in the current depressive episode; Neurological conditions that include epilepsy, cerebrovascular disease, dementia, increased intracranial pressure, having a history of repetitive or severe head trauma, or with primary or secondary tumors in the central nervous system; Are mentally or legally incapacitated, unable to give informed consent.