Depression trials in United States

In United States 271 Also abroad 664

271 trials · From ClinicalTrials.gov, checked 10 November 2026. Ask the study team whether a trial fits you.

Phase 2Taking people
Study of Neuro-Cognitive Correlates of Pediatric Anxiety Disorders
Where
Bethesda, College Park
Age
8 years to 65 years
People
3,500
Run by
National Institute of Mental Health (NIMH)
See details and how to joinNCT00018057
Phase 1Taking people
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder
Where
Bethesda
Age
18 years to 65 years
People
150
Run by
National Institute of Mental Health (NIMH)
See details and how to joinNCT03065335
No phaseTaking people
Natural History of Depression, Bipolar Disorder and Suicide Risk
Where
Bethesda
Age
18 years to 120 years
People
500
Run by
National Institute of Mental Health (NIMH)
See details and how to joinNCT06462196
Phase 3Taking people
A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)
Where
Atlanta, Austin, Bennington, Boston, Chicago, Decatur, Denver, Draper, Jacksonville, Las Vegas, Little Rock, Maitland, New York, North Charleston, Orange, Orem, Orlando, Philadelphia, San Diego, Santa Monica, Savannah, Seattle, St Louis, Tampa, Worcester
Age
18 years to 74 years
People
165
Run by
Definium Therapeutics US, Inc.
See details and how to joinNCT07592689
No phaseTaking people
Regulated Stimulation for Optimized Network Activity and Therapeutic Equilibrium
Where
Atlanta, Houston, Iowa City
Age
22 years to 85 years
People
20
Run by
Motif Neurotech, Inc.
See details and how to joinNCT07594483
No phaseTaking people
Neuromodulation of Motivation and Reward Oscillations
Where
Tallahassee
Age
18 years to 55 years
People
54
Run by
Florida State University
See details and how to joinNCT07924852
No phaseTaking people
Targeting Network Dysfunction in Apathy of Late-life Depression Using Digital Therapeutics
Where
Orlando
Age
60 years and over
People
84
Run by
AdventHealth
See details and how to joinNCT05877885
Phase 2Taking people
Psilocybin With Pimavanserin Compared to Psilocybin Alone for the Treatment of Major Depressive Disorder
Where
New York
Age
21 years to 80 years
People
60
Run by
Icahn School of Medicine at Mount Sinai
See details and how to joinNCT06592833
Phase 4Taking people
Biomarker-Guided Antidepressant Selection
Where
New York
Age
18 years to 70 years
People
27
Run by
Weill Medical College of Cornell University
See details and how to joinNCT07680140
Phase 2Taking people
ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response
Where
Birmingham, Brooklyn, Cary, Chino, Denver, Flowood, Fort Myers, Glendale, Hollywood, Houston, Katy, La Jolla, Largo, Las Vegas, Lincoln, Marlton, North Canton, Orange, Orlando, Saint Charles, Salt Lake City, Tampa, The Woodlands, Watertown, West Hills, West Palm Beach, Worcester
Age
18 years to 65 years
People
153
Run by
ACADIA Pharmaceuticals Inc.
See details and how to joinNCT07284667
No phaseTaking people
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
Where
Albuquerque, Amherst, Ammon, Ann Arbor, Atlanta, Augusta, Austin, Baltimore, Birmingham, Boca Raton, Boston, Brentwood, Brooksville, Buffalo, Burlingame, Cary, Charleston, Chicago, Cleveland, Colton, Columbia, Columbus, Costa Mesa, Dallas, Decatur, El Paso, Fairlawn, Flowood, Garfield Heights, Glen Burnie, Grayson, Hialeah, Houston, Huntington, Huntsville, Indianapolis, Jackson, Jacksonville, Joliet, Kansas City, La Jolla, Largo, Lauderhill, Lewiston, Lewisville, Lincoln, Los Angeles, Madison, Marietta, Mercer Island, Miami, Miami Springs, Minneapolis, Missouri City, Moosic, Morgantown, Naperville, Nashua, Neptune City, New York, O'Fallon, Oklahoma City, Orlando, Philadelphia, Pompano Beach, Raleigh, Roanoke, Royal Palm Beach, Saint Augustine, Salt Lake City, San Diego, San Rafael, Santa Ana, Seattle, Skokie, South Bend, Springfield, Staten Island, St Louis, Stony Brook, Syracuse, Tampa, Tulsa, West Palm Beach, Winfield, Winston-Salem, Woodbury, Woodstock
Age
18 years and over
People
6,800
Run by
LivaNova
See details and how to joinNCT03887715
Phase 2Taking people
Ketamine-Assisted Psychotherapy (KAP) Compared to Ketamine Alone for the Treatment of Depression
Where
New York
Age
18 years to 90 years
People
70
Run by
Icahn School of Medicine at Mount Sinai
See details and how to joinNCT06559826
No phaseTaking people
Peer-Delivered Behavioral Activation in a CCBHC
Where
Detroit
Age
18 years and over
People
250
Run by
Wayne State University
See details and how to joinNCT07219394
No phaseNot yet taking people in United States
Deaf CBT-TS to Reduce Suicide Risk
Where
Rochester
Age
18 years and over
People
110
Run by
University of Rochester
See details and how to joinNCT07279363
No phaseTaking people
IMST for Dementia Risk Reduction
Where
Tallahassee
Age
60 years to 80 years
People
30
Run by
Florida State University
See details and how to joinNCT07349706
Phase 3Taking people
A Study of Brenipatide in Adult Participants With Major Depressive Disorder
Where
Baltimore, Bellevue, Boston, Clinton, Decatur, DeSoto, Fairfax, Fort Worth, Foxborough, Hollywood, Indianapolis, Las Vegas, Maitland, Miami Gardens, Miami Lakes, Moorpark, Naples, New Haven, New York, Orange, Orange City, Orlando, Philadelphia, Portland, Shavano Park, Sioux Falls, St Louis, Tampa, Troy, Waterloo, Watertown, West Chester
Age
18 years to 75 years
People
1,000 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07412756 · EU 2025-522308-25-00
No phaseTaking people
Defining Neurobiological Links Between Substance Use and Mental Illness
Where
Baltimore
Age
18 years to 60 years
People
620
Run by
National Institute on Drug Abuse (NIDA)
See details and how to joinNCT05538910
Phase 3Taking people
Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder
Where
Atlanta, Avon Lake, Bellevue, Brooklyn, Cincinnati, Clermont, Columbus, Decatur, Farmington, Hialeah, Houston, Huntsville, Kansas City, Mansfield, Methuen, Miami, New York, O'Fallon, Overland Park, Philadelphia, Pico Rivera, Richardson, Tampa, Toms River
Age
18 years to 65 years
People
470 worldwide
Run by
Intra-Cellular Therapies, Inc.
See details and how to joinNCT05850689 · EU 2023-503836-41-00
Phase 3Taking people
Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms
Where
Anaheim, Atlanta, Austin, Avon Lake, Bellaire, Birmingham, Boston, Brandon, Brooklyn, Bryant, Buffalo, Chandler, Charleston, Chicago, Cincinnati, Colton, Columbus, Dallas, Decatur, Denver, Draper, Dunwoody, Edmond, Elgin, Encino, Everett, Farmington, Fort Worth, Garland, Glendale, Hialeah, Hickory, Homestead, Houston, Jacksonville, Lake City, Largo, Las Vegas, Little Rock, Los Alamitos, Mankato, Miami, Middleburg Heights, Mount Kisco, Naperville, Naples, New York, North Bay Village, Oceanside, Orlando, Philadelphia, Portsmouth, Rancho Cucamonga, Redlands, Saint Augustine, San Jose, Santa Ana, Savannah, Sherman Oaks, Snellville, Stafford, Tampa, Tucson, Watertown, West Palm Beach, Wichita Falls, Winter Park, Woodbury
Age
18 years to 74 years
People
752 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT06559306 · EU 2023-509070-36-00
Phase 3Taking people
A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disorder
Where
Atlanta, Baltimore, Birmingham, Boston, Chapel Hill, Cincinnati, East Providence, Evanston, Houston, New Haven, Rochester, Washington D.C.
Age
12 years to 17 years
People
258 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT07227454 · EU 2024-518615-19-00
Phase 1Not yet taking people in United States
Shortened LSD Intervention for Major Depressive Disorder
Where
Baltimore
Age
21 years to 70 years
People
10
Run by
Johns Hopkins University
See details and how to joinNCT07503002
Phase 3Taking people
A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder
Where
Atlanta, Baltimore, Bellevue, Bellflower, Boston, Brooklyn, Bryant, Cary, Chicago, Cincinnati, Clinton, Dallas, Doral, Edmond, Glendale, Hialeah, Houston, Las Vegas, Maitland, Marlton, Miami, Mount Kisco, New York, Oceanside, Oklahoma, Orange, Philadelphia, Riverside, Snellville, Stafford, Tampa, Walnut Creek, Watertown, West Palm Beach
Age
18 years to 74 years
People
600 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT07573176
Phase 3Taking people
A Study of Esketamine Nasal Spray Versus Placebo Spray in Adult Participants With Treatment-resistant Depression
Where
Bellevue, Cape Coral, Cedarhurst, Columbus, Farmington, Marietta, Miami, New York, Orlando, Redlands, Saint Maries, San Diego, Skokie, Snellville, Watertown
Age
18 years and over
People
348 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT07716098
Phase 3Taking people
A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder
Where
Atlantis, Austin, Baltimore, Beaumont, Bellevue, Birmingham, Boston, Bradenton, Chicago, Decatur, DeSoto, Harlingen, Hollywood, Irvine, Katy, Long Beach, Miami, Naples, Oakland, Omaha, Philadelphia, Phoenix, Provo, Sandy Springs, The Bronx, Troy, Valley Village, Watertown, West Chester, West Palm Beach
Age
18 years to 75 years
People
1,000 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07775300 · EU 2025-522310-24-00
No phaseTaking people
EEG-Guided Transcranial Magnetic Stimulation for Adults With Depression
Where
Rochester
Age
22 years to 60 years
People
60
Run by
Mayo Clinic
See details and how to joinNCT07862205