Imaging the Eye's Tiny Structures in People With Retinal Conditions
Tests high-resolution eye imaging devices in adults with retinal diseases such as retinitis pigmentosa.
Plain-language title generated from the registry record
Registry title: High Resolution, High-speed Multimodal Ophthalmic Imaging
Key facts
- Where
- Paris, FranceSee the site
Where in France
- Centre Hospitalier National D'ophtalmologie Des Quinze VingtsParis, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
- Trial code
- NCT04129021
- Record updated
- 18 November 2025
- Original description
Knowledge of the pathogenesis of ocular conditions, a leading cause of blindness, has benefited greatly from recent advances in ophthalmic imaging. However, current clinical imaging systems are limited in resolution, speed, or access to certain structures of the eye.Read full original descriptionShow less
High Resolution and High Speed Multimodal Ophthalmic Imaging
Knowledge of the pathogenesis of ocular conditions, a leading cause of blindness, has benefited greatly from recent advances in ophthalmic imaging. However, current clinical imaging systems are limited in resolution, speed, or access to certain structures of the eye.
The use of a high-resolution imaging system improves the resolution of ophthalmoscopes by several orders of magnitude, allowing the visualization of many microstructures of the eye: photoreceptors, vessels, nerve bundles in the retina, cells and nerves in the cornea.
The use of a high-speed acquisition imaging system makes it possible to detect functional measurements such as the speed of blood flow. The combination of data from multiple imaging systems to obtain multimodal information is of great importance for improving the understanding of structural changes in the eye during a disease.
The purpose of this project is to observe structures that are not detectable with routinely used systems.
Inclusion: People over 18; Patient with a pathology affecting the eye or healthy volunteer; Participant who signed the consent; Beneficiaries of the health insurance.
Exclusion: Patients who have just received a photodynamic therapy treatment (; Patients taking drugs with photosensitivity as a side effect; Patients with a history of photosensitivity; Patients with viral conjunctivitis or any other infectious disease; Patients at high risk of damage from optical radiation, such as aphakic patients, or patients with decreased sensitivity to light due to fundus disease; Persons with pacemakers or other implanted electronic medical device; Patients with skin lesions on the neck or forehead; Pregnant or lactating women; Participant unable to be followed throughout the study; Vulnerable people; Subjects with predisposition to closure of the iridocorneal angle.