Tests acupuncture for mild to moderate active Crohn's disease
Tests acupuncture in adults with mild to moderate active Crohn's disease.
Plain-language title generated from the registry record
Registry title: Effect of Acupuncture on Mild to Moderate Active Crohn's Disease
Key facts
- Where
- Shanghai, ChinaSee the 2 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 16 and 70 years old?
Source: NCT04187820, who can take part
Where in China
- Guona LiShanghai, ChinaTaking people
- Shanghai Research Institute of Acupuncture and MeridianShanghai, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Shanghai Institute of Acupuncture, Moxibustion and Meridian
- Trial code
- NCT04187820
- Record updated
- 14 May 2025
- Original description
To observe the clinical effect of acupuncture on Crohn's disease (CD) and its influence on brain function activity and the TRY-KYN metabolism level, and to screen the brain image markers of acupuncture on CDRead full original descriptionShow less
Effect of Acupuncture on Crohn's Disease Via the Regulation of Trp-kyn Metabolism in Brain-gut Axis
To observe the clinical effect of acupuncture on Crohn's disease (CD) and its influence on brain function activity and the TRY-KYN metabolism level, and to screen the brain image markers of acupuncture on CD
Inclusion: aged 16-70; patients with mild or moderate active disease (150 ≤ CDAI < 450); patients who are not responsive, intolerant, dependent or refused to use at least mesalazine, glucocorticoid, immunomodulator (azathioprine, methotrexate), anti TNF alpha preparation; patients were not taking medication or were only taking one or more of the following drugs: [prednisone ≤15mg/d, azathioprine (≤1mg/kg/d), methotrexate (≤15mg/w) or mesalazine (≤4g/d)] and prednisone was used for at least 1 month, while azathioprine, methotrexate or mesalazine was used for at least 3 months; those who did not use anti-TNF alpha and other agents within 3 months before entering the study; those who have never experienced acupuncture; patients signing informed consent.
Exclusion: patients with serious organic diseases; patients who take antibiotics, probiotics, traditional Chinese medicine and other drugs at the same time, or who suffer from multiple diseases and need to take other drugs for a long time, and may affect the observation of the efficacy of this trial; severe skin diseases (such as erythema nodosum, pyoderma gangrenosum, etc.), eye diseases (such as iritis, uveitis, etc.), thromboembolic diseases and other serious extraintestinal manifestations; there are serious intestinal fistula, abdominal abscess, intestinal stenosis and obstruction, perianal abscess, gastrointestinal hemorrhage, intestinal perforation and other complications; patients with short bowel syndrome who have undergone abdominal or gastrointestinal surgery in the past half a year; there are skin diseases or defects in the selected area of acupuncture and moxibustion that cannot be performed; patients who are recently pregnant or in pregnancy or lactation; patients diagnosed as psychosis.