Analysis of Vestibular Compensation Following Clinical Intervention for Vestibular Schwannoma
Reason given: Following further collection and analysis of temporal binding data, we found the relationship between PSS and clinical outcomes to not be strong enough for adaptation.
Key facts
- Where
- Boston, United StatesSee the site
Where in United States
- Massachusetts Eye and Ear InfirmaryBoston, United StatesNo longer taking part
Trial details
- Who runs it
- Massachusetts Eye and Ear Infirmary
- Trial code
- NCT04196933
- Record updated
- 16 April 2025
- Original description
Multiple sensory cues are typically generated by discrete events, and while they do not reach the cerebrum simultaneously, the brain can bind them temporally if they are interpreted as corresponding to a single event. The temporal binding of vestibular and non-vestibular sensory cues is poorly understood and has not been studied in detail, despite the fact that the vestibular system operates in an inherently multimodal environment. In this study, the researchers are investigating the physiology and pathophysiology of vestibular temporal binding by studying normal subjects, patients with peripheral and central vestibular dysfunction, and patients with vestibular and cochlear signals provided by prosthetic implants in the inner ear.Read full original descriptionShow less
Temporal Synthesis of Vestibular and Extra-Vestibular Sensory Signals
Multiple sensory cues are typically generated by discrete events, and while they do not reach the cerebrum simultaneously, the brain can bind them temporally if they are interpreted as corresponding to a single event. The temporal binding of vestibular and non-vestibular sensory cues is poorly understood and has not been studied in detail, despite the fact that the vestibular system operates in an inherently multimodal environment. In this study, the researchers are investigating the physiology and pathophysiology of vestibular temporal binding by studying normal subjects, patients with peripheral and central vestibular dysfunction, and patients with vestibular and cochlear signals provided by prosthetic implants in the inner ear.
Inclusion: Normal subjects; normal vestibular-oculomotor exams; normal low-frequency standard rotational testing; normal hearing; Migraine; meets International Headache Society (IHS) criteria for migraine with or without aura; tested more than 2 weeks after most recent migraine headache; Vestibular Migraine; meets Barany Society criteria for vestibular migraine, which includes:; episodic vestibular symptoms that occur with headaches that meet the IHS criteria for migraine; tested more than 2 weeks after most recent migraine headache or vestibular episode; Vestibular Schwannoma; existence of unilateral vestibular schwannoma (pre \& post clinical intervention e.g. surgical resection); must plan to have clinical intervention such as sub-occipital surgical approach with complete sectioning of the vestibular nerve; rotational testing to assess pre-surgical vestibular function; audiogram; brain MRI consistent with vestibular schwannoma; audiography in each ear; Vestibular (VI) and Cochlear (CI) Implant subjects; scheduled for CI surgery because of deafness; minimum 5 year history of documented absence of auditory and vestibular function, based on review of their audiograms and vestibular tests; specific vestibular criteria: peak ice water caloric response of less than 3deg/s for each ear; yaw VOR time constant <3s and gain <0.25; and reduced head impulse gain (<0.25) for all canal planes; specific audiographic criteria: 80dB or greater sensorineural hearing loss in both ears.
Exclusion: on vestibular suppressant medication (benzodiazepine, antihistamine, anticholinergic); on migraine prophylactic medications; on vestibular suppressant medication (benzodiazepine, antihistamine, anticholinergic); Vestibular Migraine (VM); on migraine prophylactic medication; on vestibular suppressant medication (benzodiazepine, antihistamine, anticholinergic); Vestibular Schwannoma; on vestibular suppressant medication (benzodiazepine, antihistamine, anticholinergic); history of otologic or neurologic disease; history of vestibular symptoms (other than motion sickness); other otologic disease (other than presbycusis) or any neurologic disease (other than migraine); Normal subjects; pregnant or recently (<6mos) pregnant; Migraine; evidence of other neurologic or otologic dysfunction; other neurologic or otologic dysfunction as defined above except for central eye movement findings that are consistent with VM and therefore not exclusionary.