Treating Stimulant Addiction With Repetitive Transcranial Magnetic Stimulation

Who can take part

• Structured Clinical Interview for DSM Disorders (SCID) confirmed diagnosis of SUD, severe
• Last use of stimulants >1 and <6 weeks
• Stable medication regimen (no change in dose or agents between 2 weeks prior to the start of and throughout the treatment phase of the study)
• Stable social environment and housing to enable regular attendance at clinic visits
• Ability to undergo cognitive testing, functional magnetic resonance imaging (fMRI) scans, and rTMS (no contraindications)
• Intelligence Quotient (IQ) > 80
• Stable medical health
• Veteran at Palo Alto VA's Addiction Treatment Services

Who cannot take part

• History of prior adverse reaction to TMS
• Implants or medical devices incompatible with TMS
• On medications thought to significantly lower seizure threshold, e.g.:; clozapine; chlorpromazine; clomipramine; bupropion > 400 mg/day
• History of seizures or conditions known to substantially increase risk for seizures
• Acute or unstable chronic medical illness that would affect participation or compliance with study procedures, e.g. unstable angina
• Unstable psychiatric symptoms that precludes consistent participation in the study, e.g.:; active current suicidal intent or plan; severe psychosis
• Other substance use disorder not in sustained remission
• Chronic or recurring Axis I psychiatric condition preceding SUD other than PTSD
• Pregnant or lactating female
• Use of direct dopaminergic antagonists or agonists
• Inability to undergo fMRI scan, e.g. claustrophobia, presence of ferromagnetic objects in subject's body