Follows people with severe emphysema treated with the Spiration Valve System
Studies long-term safety and effectiveness of a valve device in adults with severe emphysema.
Plain-language title generated from the registry record
Registry title: STRIVE Post-Market Registry Study
Key facts
- Where
- Anderson, Baltimore, Boston, Chicago, Coral Gables, Dallas, Durham, Gulfport, Hershey, Houston, Mountain View, Philadelphia, Phoenix, and Shreveport, United StatesSee the 16 sites
Where in United States
- AnMed HealthAnderson, United StatesTaking people
- University of MarylandBaltimore, United StatesTaking people
- Beth Israel DecaconessBoston, United StatesTaking people
- Northwestern University, Division of Pulmonary and Critical Care MedicineChicago, United StatesTaking people
- University of ChicagoChicago, United StatesTaking people
- University of MiamiCoral Gables, United StatesTaking people
- Baylor Scott & White Research InstituteDallas, United StatesTaking people
- University of Texas, SouthwesternDallas, United StatesTaking people
- Duke University Medical CenterDurham, United StatesTaking people
- Memorial Hospital at GulfportGulfport, United StatesTaking people
- Penn State Milton S. Hershey Medical CenterHershey, United StatesTaking people
- University of Texas Health Science Center at HoustonHouston, United StatesTaking people
- El Camino, Taft Center for Clinical ResearchMountain View, United StatesTaking people
- Temple UniversityPhiladelphia, United StatesTaking people
- Dignity Health St Joseph's Hospital and Medical CenterPhoenix, United StatesTaking people
- LSU Health ShreveportShreveport, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Olympus Corporation of the Americas
- Trial code
- NCT04302272
- Record updated
- 16 October 2026
- Original description
This is a single-arm, prospective, multi-center, Registry study to evaluate the long-term safety and effectiveness of the Spiration Valve System (SVS) for the treatment of severe emphysema in a post-market setting.Read full original descriptionShow less
The Spiration® Valve System (SVS) Post-Market Registry Study for Severe Emphysema
This is a single-arm, prospective, multi-center, Registry study to evaluate the long-term safety and effectiveness of the Spiration Valve System (SVS) for the treatment of severe emphysema in a post-market setting.
Inclusion: Adult patients with shortness of breath and hyperinflation associated with severe emphysema and evidence of low collateral ventilation; Subjects must understand and voluntarily sign an informed consent form.
Exclusion: Subjects who are not appropriate for SVS therapy based upon the US FDA-approved IFU requirements; Subjects who were withdrawn from this study for any reason will not be allowed to re-enroll; Subjects who have incomplete screening or baseline data.