Thermoregulation Among Individuals With First-episode Psychosis

Trial details

Who runs it

Nicholas Breitborde

Trial code

NCT04369677

Record updated

25 February 2026

Original description

The project will evaluate thermoregulatory processes among individuals with and without first-episode psychosis.Read full original descriptionShow less

The project will evaluate thermoregulatory processes among individuals with and without first-episode psychosis.

Eligibility for Individuals with First-Episode Psychosis:; Diagnosis of a schizophrenia-spectrum disorder or mood disorder with psychotic features as determined using the Structured Clinical Interview for the DSM-5 ; Less than 5 years since the onset of frank psychotic symptoms as determined using the Symptom Onset in Schizophrenia Inventory; No evidence of a pre-existing intellectual disability defined as a premorbid IQ >70 as estimated using the Reading subtest of the Wide Range Achievement Test-4; Eligibility for Individuals without First-Episode Psychosis:; No diagnosis of a schizophrenia-spectrum disorder or mood disorder with psychotic features as determined using the Structured Clinical Interview for the DSM-5; No evidence of a pre-existing intellectual disability defined as a premorbid IQ >70 as estimated using the Reading subtest of the Wide Range Achievement Test-4; Eligibility for Individuals with and without First-Episode Psychosis:; Ages 18 - 35; No evidence of swallowing difficulties as assessed using the Swallowing Disturbance Questionnaire [SDQ]. defined as (i) a score <5 on the SDQ oral phase questions, (ii) a score <11.5 on the laryngopharygeal phase SDQ questions, and a total SDQ score < 12.5; Not meeting diagnostic criteria for a substance use disorder over the past month as determined using the Structured Clinical Interview for the DSM-5 ; No current or past diagnosis of a medical condition known to affect thermoregulatory Functioning as assessed using the Health Conditions that Affect Thermoregulation questionnaire; Per recommendations from the manufacturer of the CorTemp continuous temperature sensor, we will not enroll:; Individuals who weigh less than 80 pounds; Individuals diagnosed with known or suspected obstructive diseases of the gastrointestinal tract; Individuals with a history of gag reflex disorders or impairments; Individuals with previous or scheduled gastrointestinal surgery; Individuals having felinization of the esophagus; Individuals with conditions that would result in hypomotility of the GI tract; Individuals scheduled to undergo Magnetic Resonance Imaging or Nuclear Magnetic Resonance in the next month; Individuals with cardiac pacemaker or other implanted electric medical devices.

ClinicalTrials.gov NCT04369677