Studies blood and spinal fluid in status epilepticus and dysimmune encephalitis
Collects blood and spinal fluid samples from people with severe seizures or immune-related encephalitis.
Plain-language title generated from the registry record
Registry title: Study of Pathophysiology of Status Epilepticus and Dysimmune Encephalitis
Key facts
- Where
- Paris, FranceSee the site
Where in France
- Hôpital de la Pitié-SalpêtrièreParis, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Assistance Publique - Hôpitaux de Paris
- Trial code
- NCT04421846
- Record updated
- 22 May 2026
- Original description
COLETTE is an interventional study for which blood, cerebrospinal fluid and post-mortem tissues are collected in patients with status epilepticus or epilepsy associated to dysimmune encephalitis as well as in control patients, to better understand the pathophysiology of these severe epileptic disorders.Read full original descriptionShow less
COLETTE : Study of the Pathophysiology of Status Epilepticus and Dysimmune Encephalitis and Identification of Valuable Biomarkers
COLETTE is an interventional study for which blood, cerebrospinal fluid and post-mortem tissues are collected in patients with status epilepticus or epilepsy associated to dysimmune encephalitis as well as in control patients, to better understand the pathophysiology of these severe epileptic disorders.
Inclusion: Group 1:; Patients aged 2 years or above, with status epilepticus; Affiliation to a French social security system excluding "Aide Médicale" Etat (AME); Patients or relatives have been informed and given free informed and written consent to participate; Patients under legal protection (guardianship, curatorship) or not; Group 2:; Patients aged 2 years or above, with clinical signs of epilepsy associated to dysimmune encephalitis; Affiliation to a French social security system excluding "Aide Médicale" Etat (AME); Patients or relatives have been informed and given free informed and written consent to participate; Patients under legal protection (guardianship, curatorship) or not; Group 3:; Patients aged 18 years or above, without status epilepticus and/or dysimmune encephalitis; Affiliation to a French social security system excluding "Aide Médicale" Etat (AME); Patients or relatives have been informed and given free informed and written consent to participate; Patients under legal protection (guardianship, curatorship) or not.
Exclusion: Patients with known neurodegenerative disease; Group 2:; Patients with known neurodegenerative disease, brain tumor, severe head trauma, meningitis, subarachnoid hemorrhages, stroke; Group 1:; Women with known or clinically detected pregnancy; Patient deprived of liberty; Women with known or clinically detected pregnancy; Patient deprived of liberty; Patients have been already treated by corticoids or IgIV; Group 3:; Women with known or clinically detected pregnancy; Patient deprived of liberty; Patients with status epilepticus.