Studies Sinus Surgery Outcomes in Adults With Cystic Fibrosis
Compares sinus surgery with medical care in adults with cystic fibrosis and chronic sinus inflammation.
Plain-language title generated from the registry record
Registry title: Impact of Sinus Surgery on Individuals With Cystic Fibrosis
Key facts
- Where
- Aurora, Chapel Hill, Charleston, Denver, Los Angeles, Nashville, Portland, Salt Lake City, and Stanford, United StatesSee the 9 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 99 years old?
Source: NCT04469439, who can take part
Where in United States
- University of ColoradoAurora, United StatesTaking people
- University of North CarolinaChapel Hill, United StatesTaking people
- Medical University of South CarolinaCharleston, United StatesTaking people
- National Jewish HealthDenver, United StatesTaking people
- University of California, Los AngelesLos Angeles, United StatesTaking people
- Vanderbilt University Medical CenterNashville, United StatesTaking people
- Oregon Health Science UniversityPortland, United StatesTaking people
- University of UtahSalt Lake City, United StatesTaking people
- Stanford UniversityStanford, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of California, Los Angeles
- Trial code
- NCT04469439
- Record updated
- 10 September 2026
- Original description
This study will be a prospective, observational study of patients who undergo endoscopic sinus surgery for cystic fibrosis-related chronic rhinosinusitis (CRS). Individuals who do not undergo surgery but are treated medically for CRS will also be enrolled to serve as a control group. Outcomes analyzed will include pulmonary, quality of life, and others.Read full original descriptionShow less
The Impact of Sinus Surgery in the Era of Highly Effective Modulatory Therapy
This study will be a prospective, observational study of patients who undergo endoscopic sinus surgery for cystic fibrosis-related chronic rhinosinusitis (CRS). Individuals who do not undergo surgery but are treated medically for CRS will also be enrolled to serve as a control group. Outcomes analyzed will include pulmonary, quality of life, and others.
Inclusion: Subjects between the ages of 18 years old (inclusive) and 99 years old (inclusive, subjects over the age of 89 will be recorded to be 89 years old); Diagnosed with cystic fibrosis as established by genetic testing combined with clinical assessment and/or sweat chloride; Diagnosed with chronic rhinosinusitis by multidisciplinary sinusitis guidelines; chronic rhinosinusitis symptoms persisting beyond initial medical treatment; Counseled for endoscopic sinus surgery and ongoing medical therapy with each patient electing their preferred treatment.
Exclusion: Underwent endoscopic sinus surgery in past 12 months; Will obtain follow up care at non-participating institutions; Unable to complete follow-up surveys.