Aspirin Tested for Heart Strain After Preeclampsia Delivery
Tests aspirin against a placebo in women with postpartum preeclampsia.
Plain-language title generated from the registry record
Registry title: Aspirin and Preeclampsia
Key facts
- Where
- Chicago, United StatesSee the site
- Phase
- Phase 4
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 45 years old?
Source: NCT04479072, who can take part
Where in United States
- University of Chicago HospitalChicago, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Chicago
- Trial code
- NCT04479072
- Record updated
- 4 May 2026
- Original description
This is a single-center, double-blind, randomized, placebo-controlled clinical trial. Peripartum and postpartum Activin A are significantly elevated in women with preeclampsia. Our hypothesis is that elevated Activin A levels reflect a remediable signal and that reducing postpartum Activin A levels with aspirin therapy will improve (GLS) in preeclamptic patients.Read full original descriptionShow less
Aspirin to Prevent Cardiac Dysfunction in Preeclampsia
This is a single-center, double-blind, randomized, placebo-controlled clinical trial. Peripartum and postpartum Activin A are significantly elevated in women with preeclampsia. Our hypothesis is that elevated Activin A levels reflect a remediable signal and that reducing postpartum Activin A levels with aspirin therapy will improve (GLS) in preeclamptic patients.
Inclusion: Pregnant Adults between 18 and 45 years of age; Diagnosed with preeclampsia; Presenting for delivery with a singleton gestation.
Exclusion: Co-enrolled in other trials that might affect the patients taking the study medication, as determined by the PI; Clear indication for aspirin therapy or contraindication to aspirin therapy; Currently or planning on taking any nonsteroidal anti-inflammatory drugs while they are participating in this study; Patients with preexisting cardiomyopathy, chronic hypertension, ischemic or valvular heart disease, pulmonary disease, diabetes mellitus, chronic kidney disease, multiple gestation; Aspirin allergy; Clinically significant conditions that might limit adherence to trial regimen (e.g., peptic ulcer disease, history of gastrointestinal bleeds, bleeding disorders); We will exclude patients in labor; Plan to deliver outside of the participating site; Those who cannot provide consent.