Studies patients with treatment-resistant depression receiving brain stimulation and ketamine treatments
Observes how depression treatments such as ECT, TMS and ketamine affect biological markers in adults.
Key facts
- Who runs it
- Mark Niciu
- Where
- Iowa City, United StatesSee the site
- Trial code
- Registry title
- University of Iowa Interventional Psychiatry Service Patient Registry
- Status
- Recruiting
- People taking part
- 1,000 people, planned
- Started
- 2 Nov 2020
- Expected to end
- Aug 2050
- Type of study
- Observational
- Treatments tested
- Electroconvulsive Therapy (ECT)
- Transcranial Magnetic Stimulation (TMS)
- Ketamine
- Esketamine
- Deep Transcranial Magnetic Stimulation (dTMS)
- Record updated
- 3 March 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with a major depressive episode (in major depressive disorder or bipolar disorder) or treatment-resistant OCD who are starting a treatment offered by the Interventional Psychiatry Service.
- Age
- 18 to 99 years
- Sex
- All sexes can join.
- Disease stage
- A clinical diagnosis of a major depressive episode in major depressive disorder or bipolar disorder, or treatment-resistant OCD, judged by a provider on the service to be an appropriate candidate for treatment.
Main reasons for not taking part
- Under 18 years of age
- A main psychiatric diagnosis other than major depressive disorder or bipolar disorder
- Serious, unstable medical conditions such as uncontrolled asthma, uncontrolled thyroid disease or active cancer
- Involuntary commitment to a psychiatry inpatient unit
- Cannot speak English well enough to agree to treatment and sign the consent
The registry criteria, word for word
Show all 8 criteriaShow less
Who can take part
- 18-99 years of age
- English-speaker with a level of understanding sufficient to agree to clinical treatment with a treatment modality offered by the Interventional Psychiatry Service, all required research procedures, and sign an informed consent document
- Clinical diagnosis of a major depressive episode in the context of major depressive disorder or bipolar disorder or treatment-resistant OCD evaluated by a provider on the Interventional Psychiatry Service and felt to be an appropriate candidate for clinical treatment with a treatment modality offered by the Interventional Psychiatry Service
Who cannot take part
- A primary neuropsychiatric diagnosis that is not either major depressive disorder or bipolar disorder
- Serious, unstable medical conditions/problems including hepatic, renal, gastroenterologic, respiratory, cardiovascular, endocrinologic, neurologic, immunologic, or hematologic disease, e.g. uncontrolled asthma, uncontrolled hyper/hypothyroidism or active cancer
- If patients have one or more of the following MRI Exclusion criteria, they will not be able to participate in those aspects of this study:; The presence of an implanted device including pacemaker, coronary stent, defibrillator, or neurostimulation device that is not MRI-compatible; The presence of ferromagnetic objects in the body, i.e. bullets, shrapnel, and/or metal slivers; Clinically-significant claustrophobia; Clinically-significant hearing loss; Pregnant or nursing women or women of child bearing potential not using at least one medically accepted means of contraception (to include oral, injectable, or implant birth control, condom or diaphragm with spermicide, intrauterine devices (IUD), tubal ligation, abstinence, or partner with vasectomy); The presence of any medical illness likely to alter brain morphology and/or physiology (e.g., hypertension, diabetes) even if controlled by medications
- Age less than 18 years
- Involuntary commitment to psychiatry inpatient units
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 99 years old?
Where in United States
- University of Iowa Health CareIowa City, United StatesContact: Benjamin Pace, M.S.Taking people
About the trial
What the trial wants to find out
The purpose of this study is to examine the effects of interventional/procedural therapies for treatment-resistant depression (TRD) and Obsessive-Compulsive Disorder (OCD). These treatments include electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), racemic ketamine infusion and intranasal esketamine insufflation. The investigators will obtain various indicators, or biomarkers, of a depressed individuals' state before, during, and/or after these treatments. Such biomarkers include neurobehavioral testing, neuroimaging, electroencephalography, cognitive testing, vocal recordings, epi/genetic testing, and autonomic nervous system measures (i.e. "fight-or-flight" response). The results obtained from this study may provide novel antidepressant treatment response biomarkers, with the future goal of targeting a given treatment to an individual patient ("personalized medicine").
The group in the trial
- Major Depressive Episode
After referral to the University of Iowa's Interventional Psychiatry Clinic, the patient will be clinically evaluated and, if appropriate, commence the procedural-based treatment course.
Treatment: Electroconvulsive Therapy (ECT), Transcranial Magnetic Stimulation (TMS), Ketamine, Esketamine, and Deep Transcranial Magnetic Stimulation (dTMS)
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- University of Iowa Interventional Psychiatry Service Patient Registry
- Plain-language title
- Studies patients with treatment-resistant depression receiving brain stimulation and ketamine treatmentsGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT04480918, who can take part
- Record updated
- 3 March 2026