TMS Treatment of Social Cognition Skills in Mild Cognitive Impairment

Who can take part

• Subjects aged 50 to 85 years old, inclusive, at the time of informed consent
• Must have at least 5 years of education or work experience to exclude mental deficits other than MCI
• Must meet Petersen's criteria for mild cognitive impairment, and must have:
• Clinical dementia rating global score of 0.5
• Mini-Mental State Examination score between 24 and 30
• Must have a score ≥ 26.5 at Token test to ensure that subjects have the ability to understand the instructions and procedures
• Must have a score < 29 at Beck Depression Inventory to exclude major depression that could compromise the patient's ability to engage in the study
• Apart from a clinical diagnosis of MCI, the subject must be in good health
• Must be on stable dose of antidepressant (if applicable) for at least 2 months prior to the enrolment

Who cannot take part

• Clinical significant unstable psychiatric illness requiring treatment with neuroleptic
• Transient ischemic attack, stroke, or any unexplained loss of consciousness or severe ongoing stressor within 1 year prior to screening
• History of seizure within10 years prior to screening
• Any uncontrolled medical or neurological/neurodegenerative condition (other than MCI)
• Recent history of alcohol or substance abuse or use of cannabinoids
• Any other medical conditions that are not stable or controlled, or could affect the subject's safety or interfere with the study assessments and treatment
• Contraindication to having TMS treatment
• Inability to understand the purpose of the study or to comply with study requirements