Two Drug Combinations Compared for Melanoma That Has Spread to the Brain
Compares two drug combinations in adults with melanoma that has spread to the brain.
Plain-language title generated from the registry record
Registry title: A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases
Key facts
- Where
- Aberdeen, Alton, Ames, Anaconda, Anchorage, Ann Arbor, Antigo, Aurora, Aventura, Baker City, Ballwin, Battle Creek, Beachwood, Beavercreek, Bellingham, Belpre, Bend, Billings, Birmingham, Bloomington, Boardman, Boise, Bolivar, Boone, Boulder, Bozeman, Branson, Brighton, Buffalo, Burbank, Burnsville, Caldwell, Cambridge, Canton, Cape Girardeau, Carbondale, Carroll, Carterville, Carthage, Centennial, Centerville, Centralia, Chardon, Cheyenne, Chicago, Chillicothe, Cincinnati, Clackamas, Clemmons, Cleveland, Clinton, Cody, Coeur d'Alene, Columbus, Coon Rapids, Coos Bay, Coral Gables, Danville, Dayton, Decatur, Deerfield Beach, Delaware, Denver, Des Moines, Dixon, Dublin, Eau Claire, Edina, Edmonds, Effingham, Emeryville, Emmett, Englewood, Eureka, Everett, Fairbanks, Fairhope, Farmington, Findlay, Fort Dodge, Fort Smith, Franklin, Fridley, Fruitland, Gahanna, Galesburg, Garden City, Goldsboro, Grand Rapids, Great Bend, Great Falls, Greeley, Greenville, Grove City, Issaquah, Jacksonville, Jefferson, Jefferson City, Joplin, Kalamazoo, Kalispell, Kennewick, Kettering, Kewanee, La Crosse, Lacey, Lake Forest, Lakewood, Lancaster, Lima, Lincoln, Littleton, Lone Tree, Longview, Los Angeles, Loveland, Macomb, Madison, Mansfield, Maple Grove, Maplewood, Marietta, Marion, Marshalltown, Marshfield, Martinez, Medford, Meridian, Miami, Middleburg Heights, Minneapolis, Minocqua, Missoula, Mobile, Monticello, Mount Vernon, Muskegon, Nampa, Napa, New Albany, New Richmond, New Ulm, Newark, Newberg, Niles, Norton Shores, O'Fallon, Oakland, Oklahoma City, Ontario, Oregon City, Orlando, Ottawa, Paducah, Parma, Pekin, Peoria, Perrysburg, Peru, Pittsburgh, Plantation, Port Townsend, Portland, Portsmouth, Post Falls, Princeton, Ravenna, Redmond, Reed City, Rice Lake, Richmond, Robbinsdale, Rolla, Saint Joseph, Saint Louis Park, Saint Paul, Sainte Genevieve, Salt Lake City, San Diego, Sandpoint, Sandusky, Santa Rosa, Savannah, Seattle, Sedro-Woolley, Shakopee, Shelton, Sheridan, Sioux Falls, Springfield, St Louis, Statesville, Stevens Point, Stillwater, Sullivan, Sunset Hills, Swansea, Tampa, Thornton, Toledo, Traverse City, Troy, Twin Falls, Urbana, Vancouver, Waconia, Wadsworth, Walla Walla, Walnut Creek, Warren, Washington, Wausau, West Chester, West Des Moines, Westerville, Westlake, Weston, Wilkesboro, Willmar, Winston-Salem, Wisconsin Rapids, Woodbury, Wyoming, Yelm, Yorkville, Youngstown, and Zanesville, United StatesSee the 331 sites
- Phase
- Phase 2
Where in United States
- Providence Regional Cancer System-AberdeenAberdeen, United StatesTaking people
- Saint Anthony's HealthAlton, United StatesTaking people
- Mary Greeley Medical CenterAmes, United StatesTaking people
- McFarland Clinic - AmesAmes, United StatesTaking people
- Community Hospital of AnacondaAnaconda, United StatesTaking people
- Alaska Breast Care and Surgery LLCAnchorage, United StatesTaking people
- Alaska Oncology and Hematology LLCAnchorage, United StatesTaking people
- Alaska Women's Cancer CareAnchorage, United StatesTaking people
- Anchorage Associates in Radiation MedicineAnchorage, United StatesTaking people
- Anchorage Oncology CentreAnchorage, United StatesTaking people
- Anchorage Radiation Therapy CenterAnchorage, United StatesTaking people
- Katmai Oncology GroupAnchorage, United StatesTaking people
- Providence Alaska Medical CenterAnchorage, United StatesTaking people
- University Of Michigan Comprehensive Cancer CenterAnn Arbor, United StatesTaking people
- Langlade Hospital and Cancer CenterAntigo, United StatesTaking people
- Rocky Mountain Cancer Centers-AuroraAurora, United StatesTaking people
- Rush-Copley Medical CenterAurora, United StatesTaking people
- University of Colorado HospitalAurora, United StatesTaking people
- The Medical Center of AuroraAurora, United StatesNo longer taking part
- UM Sylvester Comprehensive Cancer Center at AventuraAventura, United StatesNo longer taking part
- Saint Alphonsus Medical Center-Baker CityBaker City, United StatesTaking people
- Saint Louis Cancer and Breast Institute-BallwinBallwin, United StatesTaking people
- Bronson Battle CreekBattle Creek, United StatesTaking people
- UHHS-Chagrin Highlands Medical CenterBeachwood, United StatesTaking people
- Indu and Raj Soin Medical CenterBeavercreek, United StatesTaking people
- PeaceHealth Saint Joseph Medical CenterBellingham, United StatesTaking people
- Strecker Cancer Center-BelpreBelpre, United StatesTaking people
- Saint Charles Health SystemBend, United StatesTaking people
- Billings Clinic Cancer CenterBillings, United StatesTaking people
- University of Alabama at Birmingham Cancer CenterBirmingham, United StatesTaking people
- Illinois CancerCare-BloomingtonBloomington, United StatesTaking people
- Saint Elizabeth Boardman HospitalBoardman, United StatesTaking people
- Saint Alphonsus Cancer Care Center-BoiseBoise, United StatesTaking people
- Saint Luke's Cancer Institute - BoiseBoise, United StatesTaking people
- Central Care Cancer Center - BolivarBolivar, United StatesTaking people
- McFarland Clinic - BooneBoone, United StatesTaking people
- Boulder Community Foothills HospitalBoulder, United StatesTaking people
- Rocky Mountain Cancer Centers-BoulderBoulder, United StatesTaking people
- Bozeman Deaconess HospitalBozeman, United StatesTaking people
- Cox Cancer Center BransonBranson, United StatesTaking people
- University of Michigan - Brighton Center for Specialty CareBrighton, United StatesTaking people
- Roswell Park Cancer InstituteBuffalo, United StatesNo longer taking part
- Providence Saint Joseph Medical Center/Disney Family Cancer CenterBurbank, United StatesTaking people
- Minnesota Oncology - BurnsvilleBurnsville, United StatesTaking people
- Fairview Ridges HospitalBurnsville, United StatesNo longer taking part
- Saint Alphonsus Cancer Care Center-CaldwellCaldwell, United StatesTaking people
- Cambridge Medical CenterCambridge, United StatesTaking people
- Illinois CancerCare-CantonCanton, United StatesTaking people
- Saint Francis Medical CenterCape Girardeau, United StatesTaking people
- Southeast Cancer CenterCape Girardeau, United StatesTaking people
- Memorial Hospital of CarbondaleCarbondale, United StatesTaking people
- Saint Anthony Regional HospitalCarroll, United StatesTaking people
- SIH Cancer InstituteCarterville, United StatesTaking people
- Illinois CancerCare-CarthageCarthage, United StatesTaking people
- Rocky Mountain Cancer Centers - CentennialCentennial, United StatesTaking people
- Dayton Physicians LLC-Miami Valley SouthCenterville, United StatesTaking people
- Miami Valley Hospital SouthCenterville, United StatesNo longer taking part
- Centralia Oncology ClinicCentralia, United StatesTaking people
- Providence Regional Cancer System-CentraliaCentralia, United StatesTaking people
- Saint Mary's HospitalCentralia, United StatesTaking people
- Geauga HospitalChardon, United StatesTaking people
- Cheyenne Regional Medical Center-WestCheyenne, United StatesTaking people
- Northwestern UniversityChicago, United StatesNo longer taking part
- Adena Regional Medical CenterChillicothe, United StatesTaking people
- Oncology Hematology Care Inc-KenwoodCincinnati, United StatesTaking people
- University of Cincinnati Cancer Center-UC Medical CenterCincinnati, United StatesNo longer taking part
- Clackamas Radiation Oncology CenterClackamas, United StatesTaking people
- Providence Cancer Institute Clackamas ClinicClackamas, United StatesTaking people
- Wake Forest University at ClemmonsClemmons, United StatesTaking people
- Case Western Reserve UniversityCleveland, United StatesTaking people
- Southeastern Medical Oncology Center-ClintonClinton, United StatesTaking people
- Billings Clinic-CodyCody, United StatesTaking people
- Kootenai Health - Coeur d'AleneCoeur d'Alene, United StatesTaking people
- Columbus Oncology and Hematology Associates IncColumbus, United StatesTaking people
- Doctors HospitalColumbus, United StatesTaking people
- Grant Medical CenterColumbus, United StatesTaking people
- Mount Carmel East HospitalColumbus, United StatesTaking people
- Mount Carmel Health Center WestColumbus, United StatesTaking people
- Ohio State University Comprehensive Cancer CenterColumbus, United StatesTaking people
- Riverside Methodist HospitalColumbus, United StatesTaking people
- The Mark H Zangmeister CenterColumbus, United StatesTaking people
- Mercy HospitalCoon Rapids, United StatesTaking people
- Bay Area HospitalCoos Bay, United StatesTaking people
- UM Sylvester Comprehensive Cancer Center at Coral GablesCoral Gables, United StatesNo longer taking part
- Carle at The RiverfrontDanville, United StatesTaking people
- Dayton Physician LLC-Miami Valley Hospital NorthDayton, United StatesTaking people
- Miami Valley HospitalDayton, United StatesNo longer taking part
- Miami Valley Hospital NorthDayton, United StatesNo longer taking part
- Cancer Care Specialists of Illinois - DecaturDecatur, United StatesTaking people
- Decatur Memorial HospitalDecatur, United StatesTaking people
- UM Sylvester Comprehensive Cancer Center at Deerfield BeachDeerfield Beach, United StatesNo longer taking part
- Delaware Health Center-Grady Cancer CenterDelaware, United StatesTaking people
- Grady Memorial HospitalDelaware, United StatesTaking people
- Colorado Blood Cancer InstituteDenver, United StatesTaking people
- Presbyterian - Saint Lukes Medical Center - Health OneDenver, United StatesTaking people
- Rocky Mountain Cancer Centers-MidtownDenver, United StatesTaking people
- Rocky Mountain Cancer Centers-RoseDenver, United StatesTaking people
- The Women's Imaging CenterDenver, United StatesTaking people
- Rose Medical CenterDenver, United StatesNo longer taking part
- Western Surgical CareDenver, United StatesNo longer taking part
- Broadlawns Medical CenterDes Moines, United StatesTaking people
- Iowa Lutheran HospitalDes Moines, United StatesTaking people
- Iowa Methodist Medical CenterDes Moines, United StatesTaking people
- Medical Oncology and Hematology Associates-Des MoinesDes Moines, United StatesTaking people
- Illinois CancerCare-DixonDixon, United StatesTaking people
- Columbus Oncology and Hematology AssociatesDublin, United StatesTaking people
- Dublin Methodist HospitalDublin, United StatesTaking people
- Epic Care-DublinDublin, United StatesTaking people
- Marshfield Medical Center-EC Cancer CenterEau Claire, United StatesTaking people
- Fairview Southdale HospitalEdina, United StatesTaking people
- Swedish Cancer Institute-EdmondsEdmonds, United StatesTaking people
- Carle Physician Group-EffinghamEffingham, United StatesTaking people
- Crossroads Cancer CenterEffingham, United StatesTaking people
- Bay Area Breast Surgeons IncEmeryville, United StatesTaking people
- Epic Care Partners in Cancer CareEmeryville, United StatesTaking people
- Walter Knox Memorial HospitalEmmett, United StatesTaking people
- Mountain Blue Cancer Care Center - SwedishEnglewood, United StatesTaking people
- Rocky Mountain Cancer Centers - SwedishEnglewood, United StatesTaking people
- Swedish Medical CenterEnglewood, United StatesTaking people
- The Melanoma and Skin Cancer InstituteEnglewood, United StatesTaking people
- Illinois CancerCare-EurekaEureka, United StatesTaking people
- Providence Regional Cancer PartnershipEverett, United StatesTaking people
- Fairbanks Memorial HospitalFairbanks, United StatesTaking people
- Thomas HospitalFairhope, United StatesTaking people
- Parkland Health Center - FarmingtonFarmington, United StatesTaking people
- Armes Family Cancer CenterFindlay, United StatesTaking people
- Blanchard Valley HospitalFindlay, United StatesTaking people
- Orion Cancer CareFindlay, United StatesTaking people
- McFarland Clinic - Trinity Cancer CenterFort Dodge, United StatesTaking people
- Trinity Regional Medical CenterFort Dodge, United StatesTaking people
- Mercy Hospital Fort SmithFort Smith, United StatesTaking people
- Dayton Physicians LLC-AtriumFranklin, United StatesTaking people
- Atrium Medical Center-Middletown Regional HospitalFranklin, United StatesNo longer taking part
- Unity HospitalFridley, United StatesTaking people
- Saint Luke's Cancer Institute - FruitlandFruitland, United StatesTaking people
- Central Ohio Breast and Endocrine SurgeryGahanna, United StatesTaking people
- Illinois CancerCare-GalesburgGalesburg, United StatesTaking people
- Western Illinois Cancer Treatment CenterGalesburg, United StatesTaking people
- Central Care Cancer Center - Garden CityGarden City, United StatesTaking people
- Southeastern Medical Oncology Center-GoldsboroGoldsboro, United StatesTaking people
- Helen DeVos Children's Hospital at Spectrum HealthGrand Rapids, United StatesTaking people
- Spectrum Health at Butterworth CampusGrand Rapids, United StatesTaking people
- Trinity Health Grand Rapids HospitalGrand Rapids, United StatesTaking people
- Central Care Cancer Center - Great BendGreat Bend, United StatesTaking people
- Benefis Healthcare- Sletten Cancer InstituteGreat Falls, United StatesTaking people
- Great Falls ClinicGreat Falls, United StatesTaking people
- North Colorado Medical CenterGreeley, United StatesNo longer taking part
- Dayton Physicians LLC-WayneGreenville, United StatesTaking people
- Wayne HospitalGreenville, United StatesTaking people
- Mount Carmel Grove City HospitalGrove City, United StatesTaking people
- Zangmeister Center Grove CityGrove City, United StatesTaking people
- Swedish Cancer Institute-IssaquahIssaquah, United StatesTaking people
- Southeastern Medical Oncology Center-JacksonvilleJacksonville, United StatesTaking people
- McFarland Clinic - JeffersonJefferson, United StatesTaking people
- Capital Region Southwest CampusJefferson City, United StatesTaking people
- Freeman Health SystemJoplin, United StatesTaking people
- Mercy Hospital JoplinJoplin, United StatesTaking people
- Ascension Borgess Cancer CenterKalamazoo, United StatesTaking people
- Borgess Medical CenterKalamazoo, United StatesTaking people
- Bronson Methodist HospitalKalamazoo, United StatesTaking people
- West Michigan Cancer CenterKalamazoo, United StatesTaking people
- Kalispell Regional Medical CenterKalispell, United StatesTaking people
- Kadlec Clinic Hematology and OncologyKennewick, United StatesTaking people
- Greater Dayton Cancer CenterKettering, United StatesTaking people
- Kettering Medical CenterKettering, United StatesTaking people
- Illinois CancerCare-Kewanee ClinicKewanee, United StatesTaking people
- Gundersen Lutheran Medical CenterLa Crosse, United StatesTaking people
- Providence Regional Cancer System-LaceyLacey, United StatesTaking people
- Northwestern Medicine Lake Forest HospitalLake Forest, United StatesNo longer taking part
- Rocky Mountain Cancer Centers-LakewoodLakewood, United StatesTaking people
- Fairfield Medical CenterLancaster, United StatesTaking people
- Saint Rita's Medical CenterLima, United StatesTaking people
- Cancer Partners of Nebraska - Pine LakeLincoln, United StatesTaking people
- Southeast Nebraska Cancer Center - 68th Street PlaceLincoln, United StatesTaking people
- Rocky Mountain Cancer Centers-LittletonLittleton, United StatesTaking people
- Rocky Mountain Cancer Centers-Sky RidgeLone Tree, United StatesTaking people
- Sky Ridge Medical CenterLone Tree, United StatesNo longer taking part
- PeaceHealth Saint John Medical CenterLongview, United StatesTaking people
- UCLA / Jonsson Comprehensive Cancer CenterLos Angeles, United StatesTaking people
- McKee Medical CenterLoveland, United StatesNo longer taking part
- Illinois CancerCare-MacombMacomb, United StatesTaking people
- University of Wisconsin Carbone Cancer CenterMadison, United StatesTaking people
- OhioHealth Mansfield HospitalMansfield, United StatesTaking people
- Fairview Clinics and Surgery Center Maple GroveMaple Grove, United StatesTaking people
- Minnesota Oncology Hematology PA-MaplewoodMaplewood, United StatesTaking people
- Saint John's Hospital - HealtheastMaplewood, United StatesTaking people
- Marietta Memorial HospitalMarietta, United StatesTaking people
- OhioHealth Marion General HospitalMarion, United StatesTaking people
- McFarland Clinic - MarshalltownMarshalltown, United StatesTaking people
- Marshfield Medical Center-MarshfieldMarshfield, United StatesTaking people
- Contra Costa Regional Medical CenterMartinez, United StatesTaking people
- Aspirus Medford HospitalMedford, United StatesTaking people
- Idaho Urologic Institute-MeridianMeridian, United StatesTaking people
- Saint Luke's Cancer Institute - MeridianMeridian, United StatesTaking people
- UM Sylvester Comprehensive Cancer Center at KendallMiami, United StatesNo longer taking part
- University of Miami Miller School of Medicine-Sylvester Cancer CenterMiami, United StatesNo longer taking part
- UH Seidman Cancer Center at Southwest General HospitalMiddleburg Heights, United StatesTaking people
- Abbott-Northwestern HospitalMinneapolis, United StatesTaking people
- Health Partners IncMinneapolis, United StatesTaking people
- Hennepin County Medical CenterMinneapolis, United StatesTaking people
- Marshfield Clinic-Minocqua CenterMinocqua, United StatesTaking people
- Community Medical HospitalMissoula, United StatesTaking people
- Saint Patrick Hospital - Community HospitalMissoula, United StatesTaking people
- Mobile Infirmary Medical CenterMobile, United StatesTaking people
- Monticello Cancer CenterMonticello, United StatesTaking people
- Good Samaritan Regional Health CenterMount Vernon, United StatesTaking people
- Knox Community HospitalMount Vernon, United StatesTaking people
- Trinity Health Muskegon HospitalMuskegon, United StatesTaking people
- Saint Alphonsus Cancer Care Center-NampaNampa, United StatesTaking people
- Saint Luke's Cancer Institute - NampaNampa, United StatesTaking people
- Providence Queen of The ValleyNapa, United StatesTaking people
- Mount Carmel New Albany Surgical HospitalNew Albany, United StatesTaking people
- Cancer Center of Western WisconsinNew Richmond, United StatesTaking people
- New Ulm Medical CenterNew Ulm, United StatesTaking people
- Licking Memorial HospitalNewark, United StatesTaking people
- Newark Radiation OncologyNewark, United StatesTaking people
- Providence Newberg Medical CenterNewberg, United StatesTaking people
- Lakeland Hospital NilesNiles, United StatesTaking people
- Cancer and Hematology Centers of Western Michigan - Norton ShoresNorton Shores, United StatesTaking people
- Cancer Care Center of O'FallonO'Fallon, United StatesTaking people
- Bay Area Tumor InstituteOakland, United StatesTaking people
- Alta Bates Summit Medical Center - Summit CampusOakland, United StatesNo longer taking part
- Mercy Hospital Oklahoma CityOklahoma City, United StatesTaking people
- University of Oklahoma Health Sciences CenterOklahoma City, United StatesTaking people
- Saint Alphonsus Medical Center-OntarioOntario, United StatesTaking people
- Providence Willamette Falls Medical CenterOregon City, United StatesTaking people
- Orlando Health Cancer InstituteOrlando, United StatesTaking people
- Illinois CancerCare-Ottawa ClinicOttawa, United StatesTaking people
- Mercy Health-Paducah Medical Oncology and HematologyPaducah, United StatesTaking people
- University Hospitals Parma Medical CenterParma, United StatesTaking people
- Illinois CancerCare-PekinPekin, United StatesTaking people
- Illinois CancerCare-PeoriaPeoria, United StatesTaking people
- Methodist Medical Center of IllinoisPeoria, United StatesTaking people
- Mercy Health Perrysburg Cancer CenterPerrysburg, United StatesTaking people
- Illinois CancerCare-PeruPeru, United StatesTaking people
- Valley Radiation OncologyPeru, United StatesTaking people
- University of Pittsburgh Cancer Institute (UPCI)Pittsburgh, United StatesTaking people
- UM Sylvester Comprehensive Cancer Center at PlantationPlantation, United StatesNo longer taking part
- Jefferson HealthcarePort Townsend, United StatesTaking people
- Providence Portland Medical CenterPortland, United StatesTaking people
- Providence Saint Vincent Medical CenterPortland, United StatesTaking people
- Southern Ohio Medical CenterPortsmouth, United StatesTaking people
- Kootenai Clinic Cancer Services - Post FallsPost Falls, United StatesTaking people
- Fairview Northland Medical CenterPrinceton, United StatesTaking people
- Illinois CancerCare-PrincetonPrinceton, United StatesTaking people
- University Hospitals Portage Medical CenterRavenna, United StatesTaking people
- Saint Charles Health System-RedmondRedmond, United StatesTaking people
- Spectrum Health Reed City HospitalReed City, United StatesTaking people
- Marshfield Medical Center-Rice LakeRice Lake, United StatesTaking people
- Reid HealthRichmond, United StatesTaking people
- North Memorial Medical Health CenterRobbinsdale, United StatesTaking people
- Delbert Day Cancer Institute at PCRMCRolla, United StatesTaking people
- Mercy Clinic-Rolla-Cancer and HematologyRolla, United StatesTaking people
- Heartland Regional Medical CenterSaint Joseph, United StatesTaking people
- Lakeland Medical Center Saint JosephSaint Joseph, United StatesTaking people
- Marie Yeager Cancer CenterSaint Joseph, United StatesTaking people
- Park Nicollet Clinic - Saint Louis ParkSaint Louis Park, United StatesTaking people
- Regions HospitalSaint Paul, United StatesTaking people
- United HospitalSaint Paul, United StatesTaking people
- Sainte Genevieve County Memorial HospitalSainte Genevieve, United StatesTaking people
- Huntsman Cancer Institute/University of UtahSalt Lake City, United StatesTaking people
- Sharp Memorial HospitalSan Diego, United StatesTaking people
- Kootenai Cancer ClinicSandpoint, United StatesTaking people
- UH Seidman Cancer Center at Firelands Regional Medical CenterSandusky, United StatesTaking people
- Providence Medical Foundation - Santa RosaSanta Rosa, United StatesTaking people
- Providence Santa Rosa Memorial HospitalSanta Rosa, United StatesTaking people
- Lewis Cancer and Research Pavilion at Saint Joseph's/CandlerSavannah, United StatesNo longer taking part
- Swedish Medical Center-Ballard CampusSeattle, United StatesTaking people
- Swedish Medical Center-Cherry HillSeattle, United StatesTaking people
- Swedish Medical Center-First HillSeattle, United StatesTaking people
- Pacific Gynecology SpecialistsSeattle, United StatesNo longer taking part
- PeaceHealth United General Medical CenterSedro-Woolley, United StatesTaking people
- Saint Francis Regional Medical CenterShakopee, United StatesTaking people
- Providence Regional Cancer System-SheltonShelton, United StatesTaking people
- Welch Cancer CenterSheridan, United StatesTaking people
- Avera Cancer InstituteSioux Falls, United StatesNo longer taking part
- CoxHealth South HospitalSpringfield, United StatesTaking people
- Memorial Medical CenterSpringfield, United StatesTaking people
- Mercy Hospital SpringfieldSpringfield, United StatesTaking people
- Southern Illinois University School of MedicineSpringfield, United StatesTaking people
- Springfield ClinicSpringfield, United StatesTaking people
- Springfield Regional Cancer CenterSpringfield, United StatesTaking people
- Springfield Regional Medical CenterSpringfield, United StatesTaking people
- Mercy Hospital Saint LouisSt Louis, United StatesTaking people
- Mercy Hospital SouthSt Louis, United StatesTaking people
- Missouri Baptist Medical CenterSt Louis, United StatesTaking people
- Saint Louis Cancer and Breast Institute-South CitySt Louis, United StatesTaking people
- Wake Forest Baptist Health - Hematology Oncology - StatesvilleStatesville, United StatesTaking people
- Ascension Saint Michael's HospitalStevens Point, United StatesTaking people
- Marshfield Medical Center-River Region at Stevens PointStevens Point, United StatesTaking people
- Lakeview HospitalStillwater, United StatesTaking people
- Missouri Baptist Sullivan HospitalSullivan, United StatesTaking people
- Missouri Baptist Outpatient Center-Sunset HillsSunset Hills, United StatesTaking people
- Southwest Illinois Health Services LLPSwansea, United StatesNo longer taking part
- Moffitt Cancer CenterTampa, United StatesTaking people
- Moffitt Cancer Center - McKinley CampusTampa, United StatesTaking people
- Moffitt Cancer Center-International PlazaTampa, United StatesTaking people
- Rocky Mountain Cancer Centers-ThorntonThornton, United StatesTaking people
- Mercy Health - Saint Anne HospitalToledo, United StatesTaking people
- Saint Vincent Mercy Medical CenterToledo, United StatesTaking people
- Munson Medical CenterTraverse City, United StatesTaking people
- Dayton Physicians LLC - TroyTroy, United StatesTaking people
- Upper Valley Medical CenterTroy, United StatesNo longer taking part
- Saint Luke's Cancer Institute - Twin FallsTwin Falls, United StatesTaking people
- Carle Cancer CenterUrbana, United StatesTaking people
- The Carle Foundation HospitalUrbana, United StatesTaking people
- PeaceHealth Southwest Medical CenterVancouver, United StatesTaking people
- Ridgeview Medical CenterWaconia, United StatesTaking people
- University Hospitals Sharon Health CenterWadsworth, United StatesTaking people
- Providence Saint Mary Regional Cancer CenterWalla Walla, United StatesTaking people
- Epic Care Cyberknife CenterWalnut Creek, United StatesTaking people
- Saint Joseph Warren HospitalWarren, United StatesTaking people
- Illinois CancerCare - WashingtonWashington, United StatesTaking people
- Mercy Hospital WashingtonWashington, United StatesTaking people
- Aspirus Regional Cancer CenterWausau, United StatesTaking people
- University of Cincinnati Cancer Center-West ChesterWest Chester, United StatesNo longer taking part
- Methodist West HospitalWest Des Moines, United StatesTaking people
- Saint Ann's HospitalWesterville, United StatesTaking people
- UH Seidman Cancer Center at Saint John Medical CenterWestlake, United StatesTaking people
- Marshfield Medical Center - WestonWeston, United StatesTaking people
- Wake Forest Baptist Health - Wilkes Medical CenterWilkesboro, United StatesTaking people
- Rice Memorial HospitalWillmar, United StatesTaking people
- Wake Forest University Health SciencesWinston-Salem, United StatesTaking people
- Aspirus Cancer Care - Wisconsin RapidsWisconsin Rapids, United StatesTaking people
- Minnesota Oncology Hematology PA-WoodburyWoodbury, United StatesTaking people
- Fairview Lakes Medical CenterWyoming, United StatesTaking people
- University of Michigan Health - WestWyoming, United StatesTaking people
- Providence Regional Cancer System-YelmYelm, United StatesTaking people
- Rush-Copley Healthcare CenterYorkville, United StatesTaking people
- Saint Elizabeth Youngstown HospitalYoungstown, United StatesTaking people
- Genesis Healthcare System Cancer Care CenterZanesville, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- SWOG Cancer Research Network
- Trial code
- NCT04511013
- Record updated
- 15 September 2026
- Original description
This phase II trial compares the effect of encorafenib, binimetinib, and nivolumab versus ipilimumab and nivolumab in treating patients with BRAF- V600 mutant melanoma that has spread to the brain (brain metastases). Encorafenib and binimetinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Ipilimumab and nivolumab are monoclonal antibodies that may interfere with the ability of tumor cells to grow and spread. This trial aims to find out which approach is more effective in shrinking and controlling brain metastases from melanoma.Read full original descriptionShow less
A Randomized Phase 2 Trial of Encorafenib + Binimetinib + Nivolumab vs Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases
This phase II trial compares the effect of encorafenib, binimetinib, and nivolumab versus ipilimumab and nivolumab in treating patients with BRAF- V600 mutant melanoma that has spread to the brain (brain metastases). Encorafenib and binimetinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Ipilimumab and nivolumab are monoclonal antibodies that may interfere with the ability of tumor cells to grow and spread. This trial aims to find out which approach is more effective in shrinking and controlling brain metastases from melanoma.
Inclusion: Participants must have histologically and pathologically confirmed melanoma that has metastasized to the brain; Any primary (cutaneous, acral/mucosal, etc) or unknown origin are permitted, except that participants with uveal primary are not eligible; Participants must have BRAF-V600 mutant melanoma documented by a Clinical Laboratory Improvement Act (CLIA)-certified laboratory; All participants must have an magnetic resonance imaging (MRI) of the brain within 28 days prior to registration and must have central nervous system metastases with at least one measurable brain metastasis >= 0.5 cm in size (per modified RECIST 1.1) that has not been irradiated, or progressed (in the opinion of the treating physician) after prior radiation therapy. Participating sites MUST use MRI slice thickness of =< 1.5 mm and are recommended to adhere to the 'minimum' Brain Tumor Imaging Protocol for Clinical Trials in Brain Metastases (BTIP-BM) compliant MRI acquisition protocol. Computed tomography (CT) of the head cannot substitute for brain MRI. (NOTE: All central nervous system [CNS] disease must be documented on BOTH the Brain Metastases Baseline Tumor Assessment Form, using modified RECIST, and the Baseline Tumor Assessment Form [RECIST 1.1] using RECIST 1.1.); Participants may have measurable or non-measurable extracranial disease. All measurable disease must be assessed within 28 days prior to randomization; all non-measurable disease must be assessed within 42 days prior to randomization. Please note, while any extracranial disease will also be assessed and followed, participants are NOT required to have extracranial disease for randomization. NOTE: All disease must be assessed and documented on the Baseline Tumor Assessment Form (RECIST 1.1). CNS disease must be documented on BOTH the Brain Metastases Baseline Tumor Assessment Form, using modified RECIST, and the Baseline Tumor Assessment Form (RECIST 1.1) using RECIST 1.1; Participants may have leptomeningeal disease; Participants may be receiving corticosteroids for brain metastases at a dose of up to 8 mg of dexamethasone per day. The dose must not have exceeded 8 mg per day for at least 7 days prior to randomization; Participants must have Zubrod performance status =< 2; Participants must have complete history and physical examination within 28 days prior to randomization; Participants must be able to swallow and retain pills; Hemoglobin >= 8.0 g/dL (within 28 days prior to randomization); Absolute neutrophil count >= 1,500/mcL (within 28 days prior to randomization); Platelets >= 75,000/mcL (within 28 days prior to randomization); Total bilirubin =< 1.5 institutional upper limit of normal (ULN) (within 28 days prior to randomization); Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x institutional ULN (in participants with liver metastases =< 5 x ULN) (within 28 days prior to randomization); Creatinine =< 2.0 institutional ULN (within 28 days prior to randomization); Participants with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, must have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, participants must be class 2B or better; Participants with a prior or concurrent malignancy whose natural history or treatment (in the opinion of the treating physician) does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial; Participants with known human immunodeficiency virus (HIV)-infection are eligible providing they are on effective anti-retroviral therapy and have undetectable viral load at their most recent viral load test and within 90 days prior to randomization; Participants with a known history of hepatitis C virus (HCV) infection must have been treated and cured. Participants with HCV infection who are currently on treatment must have an undetectable HCV viral load prior to randomization; Participants must agree to participate in image banking. Images must be submitted via the Triad System; Participants must be offered the opportunity to participate in specimen and blood collections; Participants must be informed of the investigational nature of this study and must sign and give informed consent in accordance with institutional and federal guidelines; As a part of the OPEN registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system.
Exclusion: Participants must not have received prior systemic therapy for metastatic disease. Prior systemic therapy received only in the neoadjuvant and/or adjuvant setting (e.g., BRAF/MEK inhibitor therapy, anti-PD-1 therapy or anti-CTLA4 therapy, alfa-interferon, etc.) is permitted. If patients received prior neoadjuvant/adjuvant therapy, they must have had eventual disease relapse prior to randomization; Participants must not have had prior radiation therapy within 7 days prior to randomization; Participants must not be planning to require any additional form of systemic anti-tumor therapy for melanoma while on protocol treatment; Participants must not have had grade 3 or 4 immune-related adverse events on ipilimumab or nivolumab that required more than 12 weeks of immune suppression with corticosteroids; Participants must not have had adverse events related to encorafenib and/or binimetinib specifically, that required discontinuation of one or both drugs. (Please note this does not apply to other BRAF/MEK inhibitor drugs.); Participants must not be pregnant or nursing. Women/men of reproductive potential must have agreed to use an effective method of contraception. (NOTE: Patients must agree to not use hormonal contraceptives, as encorafenib can result in decreased concentration and loss of efficacy.) A woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months. In addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation. However, if at any point a previously celibate participant chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures; Participants must not have a serious active infection requiring systemic therapy at time of randomization in the opinion of the treating physician; Participants must not have active autoimmune disease that has required treatment in the past 6 months with use of biologic disease modifying agents (.e.g. infliximab, adalimumab). Patients on non-biologic disease modifying agents (e.g. methotrexate) or patients on corticosteroids =< 10 mg prednisone daily or equivalent (to treat auto-immune disease), or on replacement therapy (e.g., thyroxine, insulin) are eligible if deemed in the best interest of the patient by treating physician; Participants must not be planning to use hormonal contraceptives.