Melanoma trials in United States

In United States 269 Also abroad 579

269 trials · From ClinicalTrials.gov, checked 10 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Evaluation for NCI Surgery Branch Clinical Research Protocols
Where
Bethesda
Age
18 years and over
People
7,000
Run by
National Cancer Institute (NCI)
See details and how to joinNCT00001823
No phaseEnrolling by invitation
Harvesting Cells for Experimental Cancer Treatments
Where
Bethesda
Age
18 years and over
People
7,000
Run by
National Cancer Institute (NCI)
See details and how to joinNCT00068003
No phaseEnrolling by invitation
Follow Up Protocol for Subjects Previously Enrolled on NCI Surgery Branch Studies
Where
Bethesda
Age
18 years and over
People
1,150
Run by
National Cancer Institute (NCI)
See details and how to joinNCT00923026
Phase 2Taking people
Phase II Trial of Combination Anti-PD-1 and Aldesleukin for Metastatic Melanoma and Renal Cell Carcinoma
Where
Bethesda
Age
18 years to 120 years
People
78
Run by
National Cancer Institute (NCI)
See details and how to joinNCT05155033
No phaseNot yet taking people in United States
Clinical Genetics Branch Eligibility Screening Survey
Where
Rockville
Age
1 year to 99 years
People
1,000
Run by
National Cancer Institute (NCI)
See details and how to joinNCT07005297
No phaseEnrolling by invitation
Natural History Study of Early Life Exposures in Agriculture (ELEA)
Where
Bethesda
Age
18 years to 99 years
People
64,277
Run by
National Cancer Institute (NCI)
See details and how to joinNCT07328516
Phase 1/2Taking people
Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)
Where
Allentown, Atlanta, Billings, Camden, Chicago, Clermont, Cleveland, Dallas, Detroit, Duarte, El Paso, Fairfax, Glendale, Grand Island, Grand Rapids, Iowa City, Knoxville, La Jolla, Lakewood, Los Angeles, Louisville, Milwaukee, Murrieta, Nashville, Omaha, Orange City, Portland, Saint Louis Park, Saint Paul, San Antonio, Santa Rosa, St Louis, The Bronx, The Woodlands, Tyler
Age
18 years and over
People
340 worldwide
Run by
Inhibrx Biosciences, Inc
See details and how to joinNCT04198766
Phase 1Taking people
A Feasibility Study Utilizing Immune Recall to Increase Response to Checkpoint Therapy
Where
Durham
Age
18 years and over
People
25
Run by
Duke University
See details and how to joinNCT05077137
Phase 2Taking people
At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer
Where
Grand Forks, Jacksonville
Age
18 years and over
People
220
Run by
Mayo Clinic
See details and how to joinNCT05969860
Phase 3Taking people
A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)
Where
Albany, Ann Arbor, Asheville, Athens, Aurora, Austin, Baton Rouge, Bedford, Billings, Chandler, Charlotte, Charlottesville, Chattanooga, Cincinnati, Clermont, Cleveland, Coeur d'Alene, Columbia, Columbus, Dallas, Detroit, Durham, Easton, Edmonds, Englewood, Eugene, Fairfax, Fort Collins, Fort Wayne, Fort Worth, Fridley, Fullerton, Gilbert, Grapevine, Greenville, Hackensack, Harlingen, Hershey, Hinsdale, Houston, Issaquah, Jacksonville, Kennewick, Knoxville, Las Vegas, Lebanon, Lexington, Little Rock, Longview, Los Alamitos, Los Angeles, Lubbock, Madison, McAllen, Minneapolis, Morgantown, Nashville, New Brunswick, New Haven, Norfolk, Omaha, Orange, Palestine, Paramus, Park Ridge, Peoria, Philadelphia, Pittsburgh, Portland, Providence, Rancho Mirage, Redlands, Richmond, Roanoke, Sacramento, Salt Lake City, San Francisco, Santa Barbara, Santa Monica, Seattle, St Louis, Tamarac, Tampa, Tucson, Tulsa, Tyler, Weslaco, Westwood, Wilmington
Age
18 years and over
People
560 worldwide
Run by
Regeneron Pharmaceuticals
See details and how to joinNCT06246916
Phase 1Taking people
IL-17 Blockade to Decrease irAEs (REPLAY)
Where
Durham
Age
18 years and over
People
4
Run by
Duke University
See details and how to joinNCT07237594
Phase 1Taking people
Phase 1 Study of PF-08046033 in Advanced Solid Tumors
Where
Denver, Fairfax, Nashville, New Haven, Trumbull
Age
18 years and over
People
250 worldwide
Run by
Pfizer
See details and how to joinNCT07519655
No phaseTaking people
Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
Where
Aberdeen, Aitkin, Akron, Albert Lea, Albuquerque, Allentown, Alma, Alpena, Alton, Amarillo, Ames, Anaconda, Anchorage, Anderson, Ankeny, Ann Arbor, Antigo, Appleton, Arroyo Grande, Asheville, Ashland, Augusta, Aurora, Aventura, Baker City, Bakersfield, Ballwin, Baltimore, Baraboo, Barberton, Bardstown, Barrington, Baton Rouge, Battle Creek, Baxter, Beavercreek, Belfast, Bellingham, Belpre, Bemidji, Bend, Berlin, Bethesda, Bethlehem, Biddeford, Billings, Bismarck, Bloomington, Boardman, Boise, Bolivar, Bonita Springs, Boone, Boulder, Bozeman, Brainerd, Branson, Braselton, Brewer, Brighton, Brownstown, Brunswick, Bryan, Burbank, Burien, Burlington, Burnsville, Caldwell, Cambridge, Canton, Cape Girardeau, Carbondale, Carmichael, Caro, Carson City, Carterville, Carthage, Cary, Cedar Rapids, Centennial, Centerville, Centralia, Chaska, Chelsea, Chesapeake, Chesterfield, Cheyenne, Chicago, Chillicothe, Cincinnati, Clackamas, Clarkston, Clearwater, Clinton, Clinton Township, Clive, Clyde, Cody, Coeur d'Alene, Colorado Springs, Columbia, Columbus, Concord, Coon Rapids, Coos Bay, Corbin, Council Bluffs, Creston, Crosslake, Crystal Lake, Cudahy, Danville, Dayton, Dearborn, Decatur, Deerfield Beach, Deer River, Delaware, Denver, Des Moines, Detroit, Detroit Lakes, Dixon, Downers Grove, Dublin, Duluth, Durango, Durham, East China Township, Easton, East Stroudsburg, Eau Claire, Edgewood, Edina, Edmonds, Effingham, Elgin, Elk Grove, Elmhurst, Elmira, Ely, Emeryville, Emmett, Englewood, Enumclaw, Eureka, Everett, Evergreen Park, Fairbanks, Fargo, Farmington, Farmington Hills, Federal Way, Findlay, Fishersville, Flint, Florence, Fond du Lac, Fort Collins, Fort Dodge, Fort Lauderdale, Fort Myers, Fort Smith, Fort Thomas, Fosston, Franklin, Freehold, Fridley, Fruitland, Gaffney, Gahanna, Gainesville, Galesburg, Garden City, Garner, Georgetown, Germantown, Gladwin, Glen Burnie, Glens Falls, Goldsboro, Grafton, Grand Forks, Grand Island, Grand Rapids, Great Bend, Great Falls, Greeley, Green Bay, Greenville, Greenwood, Greer, Grosse Pointe Woods, Grove City, Hackettstown, Harvey, Havre, Hayward, Hazel Crest, Hazleton, Helena, Henderson, Hendersonville, Hibbing, Hood River, Houma, Houston, Huntington, International Falls, Issaquah, Jackson, Jacksonville, Jamaica, Jamaica Plain, Jamestown, Janesville, Jefferson, Jefferson City, Joplin, Kalamazoo, Kalispell, Kansas City, Kearney, Kennewick, Kenosha, Kettering, Kewanee, Kingman, Lacey, La Crosse, Lakeland, Lakewood, Lancaster, Lansing, Laredo, Las Cruces, Las Vegas, Leavenworth, Lewisburg, Lexington, Libertyville, Lima, Lincoln, Little Rock, Littleton, Livonia, Loma Linda, London, Lone Tree, Long Beach, Longmont, Longview, Loveland, Macomb, Madison, Manchester, Mankato, Mansfield, Maple Grove, Maplewood, Marietta, Marinette, Marion, Marlette, Marrero, Marshalltown, Martinez, Marysville, Mattoon, Meadowbrook, Mechanicsville, Medford, Medina, Merced, Meridian, Metairie, Miami Beach, Midland, Midlothian, Milwaukee, Minneapolis, Minot, Missoula, Moline, Monticello, Moose Lake, Morristown, Mount Pleasant, Mount Sterling, Mount Vernon, Mukwonago, Mullica Hill, Murrells Inlet, Muskegon, Nags Head, Nampa, Napa, Neenah, New Albany, Newark, Newberg, New Brunswick, New London, New Orleans, New Richmond, Newton, New Ulm, New York, Niles, Norfolk, Normal, Norton Shores, Novi, Oakland, Oak Lawn, Ocean Pines, Oconomowoc, Oconto Falls, O'Fallon, Oklahoma City, Olney, Omaha, Ontario, Oregon City, Osage Beach, Oshkosh, Ottawa, Paducah, Pahrump, Papillion, Parker, Park Rapids, Park Ridge, Pekin, Pennington, Peoria, Pequot Lakes, Perrysburg, Peru, Phoenix, Phoenixville, Pine River, Pittsburg, Plant City, Pompton, Pontiac, Portland, Portsmouth, Port Townsend, Post Falls, Pottstown, Princeton, Providence, Pueblo, Racine, Raleigh, Rancho Mirage, Randallstown, Reading, Redmond, Reed City, Reno, Renton, Rhinelander, Richmond, Rio Rancho, Robbinsdale, Rockford, Rocklin, Rockport, Rolla, Royal Oak, Sacramento, Safety Harbor, Saginaw, Saint Cloud, Sainte Genevieve, Saint Joseph, Saint Louis Park, Saint Paul, Salisbury, San Antonio, Sandpoint, Sandstone, Sanford, San Luis Obispo, Santa Cruz, Santa Maria, Santa Rosa, Savannah, Scarborough, Seattle, Sedro-Woolley, Shakopee, Shawano, Sheboygan, Shelton, Sheridan, Silverdale, Sioux Falls, Southfield, South Portland, Spartanburg, Spokane, Spooner, Springfield, Staples, Sterling Heights, Stevens Point, St. Helena, Stillwater, St Louis, Stockton, Stony Brook, St. Petersburg, Sturgeon Bay, Sullivan, Summit, Superior, Tacoma, Tampa, Tawas City, Thief River Falls, Thornton, Tifton, Toledo, Topeka, Towson, Traverse City, Troy, Twin Falls, Two Rivers, Union, Urbana, Vancouver, Vineland, Virginia, Virginia Beach, Waconia, Walla Walla, Walnut Creek, Warren, Warwick, Washington, Washington D.C., Waukee, Waukesha, Waupaca, Wausau, Wauwatosa, Weaverville, West Allis, West Bloomfield, West Branch, West Columbia, West Des Moines, Westerville, West Haven, Westminster, West Reading, Wichita, Wilkes-Barre, Willmar, Wilmington, Winter Haven, Wisconsin Rapids, Woodbury, Woodland, Worthington, Wyandotte, Wyoming, Yakima, Yelm, Yorkville, Youngstown, Ypsilanti, Zanesville
Age
40 years to 75 years
People
2,900
Run by
Alliance for Clinical Trials in Oncology
See details and how to joinNCT05334069
Phase 2Taking people
Positron Emission Tomography (PET) Guided Stereotactic Body Radiation Therapy for the Treatment of Oligoprogressive Non-small Cell Lung Cancer, Melanoma, and Renal Cell Carcinoma
Where
Duarte, Irvine
Age
18 years and over
People
32
Run by
City of Hope Medical Center
See details and how to joinNCT05830058
Phase 1Taking people
A Phase 1 of CTX-8371 in Patients With Advanced Malignancies
Where
Athens, Birmingham, Boston, Buffalo, Fort Wayne, Margate, Nashville, Orlando, Palo Alto, Sarasota, Spokane
Age
18 years and over
People
85
Run by
Compass Therapeutics
See details and how to joinNCT06150664
No phaseTaking people
Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics
Where
‘Aiea, Albemarle, Albert Lea, Albuquerque, Allentown, Alma, Alpena, Alton, Anaconda, Anderson, Ankeny, Ann Arbor, Antigo, Antioch, Appleton, Arroyo Grande, Asheboro, Ashland, Atlanta, Augusta, Aurora, Baker City, Ballwin, Baltimore, Bardstown, Barrington, Battle Creek, Beaufort, Beavercreek, Belfast, Bellevue, Bellingham, Belpre, Berlin, Berlin Corners, Bethlehem, Bettendorf, Biddeford, Billings, Bloomington, Bluffton, Boardman, Boiling Springs, Boise, Boulder, Bozeman, Brainerd, Brookfield, Brunswick, Burlington, Burnsville, Caldwell, Canton, Carmichael, Carterville, Carthage, Cedar Rapids, Centennial, Centralia, Chambersburg, Charleston, Charlotte, Chaska, Chicago, Chilton, Chippewa Falls, Clearwater, Clemmons, Clive, Coeur d'Alene, Collierville, Colorado Springs, Columbus, Concord, Coon Rapids, Crystal Lake, Cudahy, Danville, Dayton, Decatur, Deer River, Denver, Des Moines, Detroit Lakes, Dickson City, Dixon, Downers Grove, Dublin, Duluth, Easley, East Stroudsburg, Eau Claire, Edina, Edmonds, Effingham, Elgin, Elk Grove, Elkton, Englewood, Ephrata, Escanaba, Eureka, ‘Ewa Beach, Fairbanks, Fargo, Farmington, Findlay, Fishersville, Flint, Florence, Forest City, Fort Smith, Fosston, Franklin, Fredericksburg, Freehold, Fremont, Fresno, Gaffney, Galesburg, Gastonia, Georgetown, Germantown, Gettysburg, Gladwin, Glen Burnie, Glens Falls, Grafton, Grand Rapids, Great Falls, Green Bay, Greensboro, Greenville, Greer, Grenada, Hackettstown, Havre, Hays, Hayward, Hazel Crest, Hazleton, Henderson, Hibbing, High Point, Hilton Head Island, Hinesville, Honolulu, Huntersville, Huntington, Iowa City, Iron Mountain, Issaquah, Jamaica, Jesup, Jonesboro, Joplin, Kalamazoo, Kalispell, Kansas City, Kearney, Kennewick, Kenosha, Kettering, Kewanee, Kingman, La Crosse, Ladysmith, Lafayette, Lakewood, Lancaster, Las Cruces, Las Vegas, Lawrence, Lawrenceville, Lebanon, Lee's Summit, Lewisburg, Lexington, Libertyville, Lihue, Lincolnton, Littleton, London, Lone Tree, Longmont, Lynchburg, Macomb, Macon, Madison, Mankato, Maplewood, Marinette, Marshfield, Martinez, Martinsville, Marysville, Matthews, Mattoon, Medford, Memphis, Mequon, Michigan City, Midland, Millville, Milwaukee, Minneapolis, Minocqua, Missoula, Modesto, Monroe, Monticello, Morristown, Mount Pleasant, Mount Sterling, Mount Vernon, Murrells Inlet, Muskegon, Nampa, Neenah, Neillsville, New Albany, Newark, New London, New Richmond, Newton, New Ulm, New York, Normal, Norton Shores, Oakland, Oak Lawn, Oconto Falls, O'Fallon, Oklahoma City, Olathe, Ontario, Orangeburg, Osage Beach, Oshkosh, Oswego, Ottawa, Overland Park, Oxford, Paducah, Palos Heights, Park Rapids, Park Ridge, Pekin, Peoria, Peru, Phoenix, Plant City, Pompton, Pontiac, Portland, Port Townsend, Post Falls, Pottsville, Princeton, Pueblo, Racine, Rapid City, Redwood City, Reed City, Rehoboth Beach, Reidsville, Rhinelander, Rice Lake, Richmond, Rio Rancho, Roanoke, Robbinsdale, Rochester, Rockford, Rock Hill, Rocklin, Rockport, Roseville, Sacramento, Saginaw, Saint Cloud, Sainte Genevieve, Saint Joseph, Saint Louis Park, Saint Paul, Salina, Sandpoint, Sandstone, Sanford, San Francisco, San Jose, San Leandro, San Luis Obispo, San Rafael, Santa Clara, Santa Maria, Santa Rosa, Savannah, Scarborough, Scranton, Seattle, Sedro-Woolley, Seneca, Shakopee, Shawano, Sheboygan, Shelby, Shreveport, Southaven, South Hill, South Portland, South San Francisco, Spartanburg, Spooner, Springfield, Stevens Point, St. Helena, Stillwater, St Louis, Stockton, St. Petersburg, Sturgeon Bay, Sullivan, Summit, Sunset Hills, Syracuse, Tampa, Tawas City, Teaneck, The Bronx, Thornton, Topeka, Towson, Traverse City, Two Rivers, Union, Urbana, Vacaville, Vallejo, Verona, Virginia, Waconia, Walla Walla, Walnut Creek, Warren, Washington, Waukee, Waupaca, Wausau, Wauwatosa, West Allis, Westminster, Weston, Westwood, Wilkes-Barre, Willmar, Winchester, Winston-Salem, Winter Haven, Wisconsin Rapids, Woodbury, Woodland, Wyoming, York, Yorkville, Youngstown
Age
18 years and over
People
2,000 worldwide
Run by
Wake Forest University Health Sciences
See details and how to joinNCT06418204
Phase 2Taking people
A Study of Navlimetostat (BMS-986504) Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)
Where
Ann Arbor, Atlanta, Aurora, Baltimore, Boston, Buffalo, Durham, Houston, Madison, New York, Rochester, San Francisco, Seattle
Age
18 years and over
People
254 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT07492680
Phase 1Taking people
SI-B036-ST-101 in Advanced/Metastatic Solid Tumors
Where
Dallas, Houston, Nashville, New Haven, Oklahoma City, Orlando, Sarasota
Age
18 years and over
People
424
Run by
SystImmune Inc.
See details and how to joinNCT07857616
Phase 4Taking people
Dabrafenib and/or Trametinib Rollover Study
Where
Bethesda, Columbus, Dallas, Scottsdale
Age
18 years to 100 years
People
100 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT03340506 · EU 2023-509318-13-00
Phase 2Taking people
BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study
Where
‘Aiea, Albuquerque, Alexandria, Ames, Anaconda, Ankeny, Ann Arbor, Ashland, Aurora, Battle Creek, Bellevue, Bemidji, Bend, Beverly Hills, Billings, Bismarck, Bloomington, Boise, Boone, Boston, Bozeman, Brainerd, Brighton, Burnsville, Caldwell, Canton, Cape Girardeau, Carthage, Cedar Rapids, Centerville, Centralia, Chaska, Chelsea, Chicago, City of Saint Peters, Clackamas, Clinton, Clive, Coeur d'Alene, Colorado Springs, Coon Rapids, Creve Coeur, Danville, Dayton, Decatur, Deer River, DeKalb, Des Moines, Detroit, Detroit Lakes, Dixon, Duluth, Eau Claire, Edina, Effingham, Escanaba, Eureka, Fairfax, Falls Church, Fargo, Farmington Hills, Flint, Fort Collins, Fort Dodge, Fosston, Franklin, Fridley, Fruitland, Galesburg, Geneva, Glenview, Goldsboro, Grand Rapids, Grayslake, Great Falls, Greeley, Green Bay, Greenville, Hibbing, Honolulu, Irvine, Jacksonville, Jamestown, Jefferson, Kalamazoo, Kalispell, Kewanee, La Crosse, Lake Forest, Lake Success, Lansing, Lebanon, Little Rock, Livonia, Los Angeles, Loveland, Lynchburg, Macomb, Maplewood, Marshalltown, Marshfield, Mattoon, Maywood, Meridian, Milwaukee, Mineola, Minneapolis, Minocqua, Missoula, Mukwonago, Muskegon, Nampa, Newark, Newberg, New Richmond, New York, Niles, Normal, Norton Shores, Oconomowoc, Oconto Falls, O'Fallon, Oklahoma City, Omaha, Ontario, Orange, Oregon City, Orlando, Orland Park, Ottawa, Park Rapids, Pekin, Peoria, Peru, Philadelphia, Phoenix, Pontiac, Portland, Post Falls, Princeton, Rapid City, Reed City, Rice Lake, Richmond, Rochester, Saint Johnsbury, Saint Joseph, Saint Louis Park, Saint Paul, Salt Lake City, Sandpoint, Sandstone, Sheboygan, Shiloh, Sioux Falls, Springfield, Stevens Point, St Louis, Stoneham, Sturgeon Bay, Superior, Tappahannock, Traverse City, Troy, Twin Falls, Urbana, Virginia, Waconia, Warrenville, Washington, Waukee, Waukesha, Weston, Willow Grove, Woodbury, Wyoming, Yorkville, Ypsilanti
Age
18 years and over
People
150
Run by
National Cancer Institute (NCI)
See details and how to joinNCT05136196
Phase 1/2Taking people
Safety and Efficacy of OBX-115 in Advanced Solid Tumors
Where
Columbus, Houston, Los Angeles, Louisville, Miami, New York, Orlando, Pittsburgh, Stanford, Tampa, Tucson
Age
18 years and over
People
254 worldwide
Run by
Obsidian Therapeutics, Inc.
See details and how to joinNCT06060613
Phase 1/2Taking people
A First-in-human Study of RLY-8161 in Advanced NRAS-Mutant Solid Tumors
Where
Aurora, Boston, Fairfax, Grand Rapids, Los Angeles, Nashville, New York, San Francisco
Age
18 years and over
People
180
Run by
Relay Therapeutics, Inc.
See details and how to joinNCT07584226
Phase 1/2Taking people
A Phase 1 and 2 Study of VMD-102 in Hepatocellular Carcinoma and Other Solid Tumors
Where
Los Angeles, Scottsdale
Age
18 years to 75 years
People
111
Run by
VM Discovery, Inc.
See details and how to joinNCT07636785
Phase 1Taking people
Dose Ranging, Toxicity Seeking, Phase 1 Trial of Oncolytic Adenoviral Therapy for Melanoma Intracranial and Extracranial Metastases
Where
Houston
Age
18 years and over
People
50
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT07444606
No phaseTaking people
Aggressive Lipid Lowering Therapy in ICI-Treated Melanoma
Where
Aurora
Age
55 years and over
People
40
Run by
University of Colorado, Denver
See details and how to joinNCT07704918