Faster MRI scans to find early cartilage changes in osteoarthritis

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adult volunteers to test new, faster knee MRI scans. One group is people with a recent full ACL tear in one knee. The other groups are volunteers without knee problems.

Age

Group 1: over 18. Groups 2, 3 and 4: 18 to 50 years.

Sex

All sexes can join.

Disease stage

Group 3: a recent (acute) full ACL tear in one knee, with the other knee uninjured. Groups 2 and 4: no osteoarthritis or inflammatory arthritis.

Earlier treatment

Group 3: people must have ACL reconstruction surgery and standard rehabilitation. Groups 2 and 4: no earlier injury or surgery on either knee.

Main reasons for not taking part

• Cannot have an MRI, for example severe fear of closed spaces (claustrophobia)
• Implanted devices such as neurostimulators, pacemakers or aneurysm clips
• Pregnancy
• Groups 2 and 4: history of osteoarthritis or inflammatory arthritis, or earlier knee injury or surgery
• Group 3: unable to do standard rehabilitation before and after injury or surgery

The registry criteria, word for word

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

• Are you between 18 and 50 years old?YesNo

What the trial wants to find out

Currently the diagnosis of OA is based on radiographs and clinical findings, which is limited to detecting late-stage disease. There is a pressing, unmet clinical need for robust assessment of early changes in cartilage health. Towards this goal, extensive efforts are ongoing to develop quantitative MRI for cartilage matrix analysis. MR T1ρ and T2 relaxation times have shown to be promising imaging biomarkers for early cartilage degeneration and prediction of disease progression. However, many challenges remain to clinically applying these techniques, including lack of standardized acquisition and quantification methods, and long acquisition times. The study aims to develop novel, fast and reproducible MR T1ρ and T2 relaxation time imaging methods on MR systems from multiple vendors and establish a platform for standardization and cross validation of these measures as a tool for clinical trials using such techniques. Following method validation, patients at risk for osteoarthritis will be tested.

The 4 groups in the trial

• Cleveland Clinic Foundation (CCF) Volunteers

  The group will be used for evaluating differences between standard T1rho and T2 imaging vs accelerated T1rho and T2 imaging techniques that will be developed from this study.

  Treatment: MRI

• Traveling Volunteers

  The group will be recruited at CCF and be scanned at CCF, University of California San Francisco, University of Kentucky and Albert Einstein College of Medicine.

  Treatment: MRI

• ACL tear Volunteers

  This group will be recruited at CCF and scanned at baseline and 1-year at all of the three MR systems at CCF (Siemens, GE, Philips).

  Treatment: MRI

• Group Matched to ACL tear Volunteers

  This group will be recruited at CCF and scanned at baseline and 1-year at all of the three MR systems at CCF (Siemens, GE, Philips).Traveling Volunteers share the same inclusion and exclusion criteria as this group, therefore subjects can participate the study and serve as subjects within both groups

  Treatment: MRI