Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry
Key facts
- Who runs it
- Xiaojuan Li
- Where
- Cleveland, United StatesSee the site
- Trial code
- Status
- Recruiting
- People taking part
- 88 people, planned
- Started
- 1 Apr 2022
- Expected to end
- 28 Dec 2026
- Type of study
- Observational, 4 groups
- Treatments tested
- MRI
- Record updated
- 27 February 2026
Who can take part
- Age
- 18 years to 50 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 21 criteriaShow less
Who can take part
- Group 1
- Age > 18; Group 2
- Age 18-50; Group 3
- Age 18-50
- Sustain an acute full ACL tear in one knee; the contralateral knee uninjured
- Undergo ACL reconstructions and standard rehabilitation; Group 4
- Age 18-50
Who cannot take part
- Previous injury and/or surgery on either knee; Group 3
- Previous injury and/or surgery on either knee
- History of osteoarthritis and inflammatory arthritis
- History of osteoarthritis and inflammatory arthritis
- Group 1
- Contraindication to MRI such as severe claustrophobia and implanted devices such as neurostimulators, pacemakers, aneurysm clips etc
- Pregnancy; Group 2
- Contraindication to MRI such as severe claustrophobia and implanted devices such as neurostimulators, pacemakers, aneurysm clips etc
- Pregnancy
- Contraindication to MRI such as severe claustrophobia and implanted devices such as neurostimulators, pacemakers, aneurysm clips etc
- Pregnancy
- Inability to undergo standard pre- and post-injury/operative rehabilitation; Group 4
- Contraindication to MRI such as severe claustrophobia and implanted devices such as neurostimulators, pacemakers, aneurysm clips etc
- Pregnancy
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 50 years old?
Where in United States
- Cleveland Clinic FoundationCleveland, United StatesContact: Xiaojuan Li, PhDTaking people
About the trial
What the trial wants to find out
Currently the diagnosis of OA is based on radiographs and clinical findings, which is limited to detecting late-stage disease. There is a pressing, unmet clinical need for robust assessment of early changes in cartilage health. Towards this goal, extensive efforts are ongoing to develop quantitative MRI for cartilage matrix analysis. MR T1ρ and T2 relaxation times have shown to be promising imaging biomarkers for early cartilage degeneration and prediction of disease progression. However, many challenges remain to clinically applying these techniques, including lack of standardized acquisition and quantification methods, and long acquisition times. The study aims to develop novel, fast and reproducible MR T1ρ and T2 relaxation time imaging methods on MR systems from multiple vendors and establish a platform for standardization and cross validation of these measures as a tool for clinical trials using such techniques. Following method validation, patients at risk for osteoarthritis will be tested.
The 4 groups in the trial
- Cleveland Clinic Foundation (CCF) Volunteers
The group will be used for evaluating differences between standard T1rho and T2 imaging vs accelerated T1rho and T2 imaging techniques that will be developed from this study.
Treatment: MRI
- Traveling Volunteers
The group will be recruited at CCF and be scanned at CCF, University of California San Francisco, University of Kentucky and Albert Einstein College of Medicine.
Treatment: MRI
- ACL tear Volunteers
This group will be recruited at CCF and scanned at baseline and 1-year at all of the three MR systems at CCF (Siemens, GE, Philips).
Treatment: MRI
- Group Matched to ACL tear Volunteers
This group will be recruited at CCF and scanned at baseline and 1-year at all of the three MR systems at CCF (Siemens, GE, Philips).Traveling Volunteers share the same inclusion and exclusion criteria as this group, therefore subjects can participate the study and serve as subjects within both groups
Treatment: MRI
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Fit questions
- Built from NCT04536103, who can take part
- Record updated
- 27 February 2026