Studying Liver Failure Risk After Surgery in Chronic Liver Disease Patients
Observes which factors predict acute liver failure after surgery in people with chronic liver disease.
Plain-language title generated from the registry record
Registry title: Predicting Acute-on-Chronic Liver Failure After Surgical Intervention in Chronic Liver Disease
Key facts
- Where
- Bonn, GermanySee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with or without liver cirrhosis, or with portal hypertension without cirrhosis, who need surgery. It studies who develops acute-on-chronic liver failure after surgery.
- Age
- 18 years or older
- Sex
- Men and women
- Disease stage
- Liver cirrhosis, or portal hypertension without cirrhosis, with an indication for surgery
- Earlier treatment
- No previous liver or other transplantation
Main reasons for not taking part
- Pregnant or breastfeeding women
- Surgery as palliative cancer therapy
- Severe diseases outside the liver, now or in the past
- HIV-positive patients
- Acute or subacute liver failure without cirrhosis
Read by machine on 12 November 2026.
Where in Germany
- University Hospital BonnBonn, GermanyContact: Michael Praktiknjo, MDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- University Hospital, Bonn
- Trial code
- NCT04578301
- Record updated
- 18 May 2022
- Original description
Prospective, observational study to define precipitants and predictors of development of Acute-on-Chronic Liver Failure (ACLF) after surgical interventions, allowing to develop a risk stratification for elective procedures in cirrhotic patients. As well as identifying molecular mechanisms of post-interventional ACLF and thus preparing the ground for development of new therapeutic approaches.Read full original descriptionShow less
Predicting Acute-on-Chronic Liver Failure After Surgical Intervention in Chronic Liver Disease
Prospective, observational study to define precipitants and predictors of development of Acute-on-Chronic Liver Failure (ACLF) after surgical interventions, allowing to develop a risk stratification for elective procedures in cirrhotic patients. As well as identifying molecular mechanisms of post-interventional ACLF and thus preparing the ground for development of new therapeutic approaches.
Inclusion: Male or female adult (≥18 years) patient; With or without liver cirrhosis (diagnosed either histologically or by a combination of clinical, laboratory and radiological signs); Or Non-cirrhotic portal hypertension; Non-pregnant, non-lactating females; Ability to understand the patient information and to personally sign and date the informed consent to participate in the study; The patient is co-operative and available for the entire study; Provided written informed consent; Indication for surgical intervention.
Exclusion: Previous liver or other transplantation; Patients undergoing surgery as form of palliative cancer therapy; Presence or history of severe extra-hepatic diseases; HIV-positive patients; Patients with acute or subacute liver failure without underlying cirrhosis; Pregnant or lactating females; Patients who decline to participate; Physician´s denial (e.g. the investigator considers that the patient will not follow the protocol scheduled).