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Taking people in United StatesPhase 1

Xenon gas MRI scans to study lung function in people with lung disease

Tests a xenon gas MRI scan of lung function in healthy people and lung disease.

Plain-language title generated from the registry record
Registry title: Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease

Key facts

Where
Kansas City, United StatesSee the site
Phase
Phase 1

Where in United States

  • University of Kansas Medical CenterKansas City, United StatesTaking people

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  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?
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Trial details

Who runs it
Mario Castro, MD, MPH
Trial code
NCT04624490
Record updated
6 May 2026
Original description
The purpose of this study is to develop and evaluate the usefulness of hyperpolarized (HP) 129Xe gas MRI for regional assessment of pulmonary function.Read full original descriptionShow less

Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease

The purpose of this study is to develop and evaluate the usefulness of hyperpolarized (HP) 129Xe gas MRI for regional assessment of pulmonary function.

Inclusion: Healthy Volunteers:; Subject has no diagnosed pulmonary conditions; Ability to read and understand English or Spanish; Subjects with Lung Disease:; Subject has a diagnosis of pulmonary dysfunction made by a physician; No acute worsening of pulmonary function in the past 30 days; Ability to read and understand English or Spanish.

Exclusion: MRI is contraindicated based on responses to MRI screening questionnaire; Subject is pregnant or lactating; Subject does not fit into 129Xe vest coil used for MRI; Subject cannot hold his/her breath for 15-16 seconds; Subject deemed unlikely to be able to comply with instructions during imaging; Oxygen saturation <88% on room air or with supplemental oxygen; Cognitive deficits that preclude ability to provide consent; Institutionalization.

ClinicalTrials.gov NCT04624490