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Enrolling by invitationNo phase

MOON Onsite MRI 10 Years After ACL Reconstruction

Key facts

Who runs it
The Cleveland Clinic
Where
Cleveland, United StatesSee the site
Trial code
Status
Enrolling by invitation
People taking part
219 people, planned
Started
1 Jan 2020
Expected to end
1 Jan 2030
Type of study
Observational, 2 groups
Treatments tested
  • No Intervention - Observational study with MRI
Record updated
24 August 2026

Who can take part

Age
22 years to 45 years
Sex
Women and men
Healthy volunteers
Can take part

The registry criteria, word for word

Show all 8 criteriaShow less

Who can take part

  • Enrolled in MOON Onsite Study
  • 12-33 years old at baseline (22-45 years for this study)
  • ACL tear during a sport; no previous knee injury
  • No graft rupture during follow-up
  • No history of surgery on the contralateral knee
  • No MRI contraindications

Who cannot take part

  • History of surgery on contralateral knee
  • Afraid of enclosed spaces

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 22 and 45 years old?

Where in United States

  • Cleveland ClinicCleveland, United StatesNo longer taking part

About the trial

What the trial wants to find out

In this study, a total of 219 subjects from the MOON nested cohort will be studied at CCF, Vanderbilt and OSU, Table 1. Among them, some will have added MRI during their 10-year visit for the MOON study. Some subjects who finished their 10-year visit for the MOON Onsite study already will be called back to have MRI. PROMs and other information of these subjects will be collected through the MOON study.

The 2 groups in the trial

  • Patients

    Patients who had ACL reconstruction

    Treatment: No Intervention - Observational study with MRI

  • Controls

    Controls who have no previous knee injury or surgery, no diagnosis of osteoarthritis

    Treatment: No Intervention - Observational study with MRI

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Imaging Post-traumatic Osteoarthritis 10-years After ACL Reconstruction
Fit questions
Built from NCT04660955, who can take part
Record updated
24 August 2026