Studies how diet and gut bacteria may relate to colorectal cancer
Observes how diet affects gut bacteria and possible colorectal cancer development in adults.
Plain-language title generated from the registry record
Registry title: Role of Diet on the Microbiome of the Digestive System
Key facts
- Where
- Houston, United StatesSee the site
Where in United States
- M D Anderson Cancer CenterHouston, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- M.D. Anderson Cancer Center
- Trial code
- NCT04666727
- Record updated
- 10 November 2026
- Original description
This study is to learn more about how diet affects the microbiome (bacteria and microorganisms) of the digestive system. Researchers want to learn if this, in turn, has an effect on if and how people then develop colorectal cancer.Read full original descriptionShow less
The Role of Diet and the Microbiome in Inducing Somatic Mutations in Colorectal Epithelial Cells and Its Predisposition to Carcinogenesis - A Pilot Study
This study is to learn more about how diet affects the microbiome (bacteria and microorganisms) of the digestive system. Researchers want to learn if this, in turn, has an effect on if and how people then develop colorectal cancer.
Inclusion: GROUP I: Patients presenting for a screening colonoscopy; GROUP I: Age of 45 and above; GROUP I: Strict vegetarian diet, determined by using diet history questionnaire 3.0 National Institutes of Health (NIH); GROUP I: Non smoker; GROUP I: Ability to understand and willingness to sign an informed consent form, complete web based dietary assessment and provide stool, colonic mucosa and blood samples; GROUP II: Patients presenting for a screening colonoscopy; GROUP II: Age of 45 and above; GROUP II: Omnivorous diet; GROUP II: Non smoker; GROUP II: Ability to understand and willingness to sign an informed consent form, complete web based dietary assessment and provide stool, colonic mucosa and blood sample.
Exclusion: • Current smokers (nicotine abuse only); Positive family history of colon cancer or colon cancer related syndromes; Recent use of antibiotics in 1 month; History of inflammatory bowel disease, and/or radiation enteritis or colitis; Pregnant and breastfeeding women; Women of child-bearing potential who have positive urine or serum pregnancy test; Heavy drinker (defined as more than 14 drinks per week); Currently using anti-flatulence medications, probiotics and/or fiber supplements; Major dietary restrictions and/or following a special diet; Patient with positive fecal test/symptoms.