Studying immune cells in fat tissue and insulin resistance in people with obesity
Looks at immune cells in belly and under-skin fat in adults with obesity.
Key facts
- Who runs it
- Stanford University
- Where
- Stanford, United StatesSee the site
- Trial code
- Registry title
- Adaptive Immune Response in Visceral and Subcutaneous Fat: Role in Human Insulin Resistance
- Status
- Enrolling by invitation
- People taking part
- 50 people, planned
- Started
- 1 Aug 2017
- Planned end
- Aug 2026
- Type of study
- Observational
- Record updated
- 13 May 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults aged 30 to 65 who are scheduled for weight-loss (bariatric) surgery at Stanford, are in good general health and do not have diabetes.
- Age
- 30 to 65 years
- Sex
- All sexes can join.
- Disease stage
- Body mass index (BMI) 30-55kg/m2. Not diabetic: fasting glucose below 126mg/dl (7 mmol/L). Good general health, no major organ disease.
- Earlier treatment
- Must be scheduled for sleeve or RYGB bariatric surgery. People who have had bariatric surgery before cannot join.
- Biomarker or test result
- Fasting glucose below 126mg/dl (7 mmol/L).
Main reasons for not taking part
- Significant anemia, or stomach/bowel, heart, liver or kidney disease
- Active psychiatric disorder
- Past bariatric surgery
- Pregnant or breastfeeding women
The registry criteria, word for word
Show all 9 criteriaShow less
Who can take part
- Current patients of Stanford Healthcare, Bariatric Surgery Clinic, scheduled to undergo bariatric surgery (sleeve or RYGB)
- BMI 30-55kg/m2
- 30-65 years of age
- good general health, no major organ disease
- non-diabetic by current American Diabetes Association (ADA) criteria (fasting glucose <126mg/dl)
Who cannot take part
- Subjects with any clinical or biochemical evidence of significant anemia, gastrointestinal, cardiac, hepatic or renal disease will be excluded
- Subjects with active psychiatric disorders or past history of bariatric surgery
- Subjects with other medical problems may participate as long as the problems are stable
- Pregnant or lactating women will also be excluded from the study, due to possible risk to the fetus or infant
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 30 and 65 years old?
Where in United States
- Stanford UniversityStanford, United StatesEnrolling by invitation
About the trial
What the trial wants to find out
The proposed study is designed to test the hypothesis that in human obesity, the balance of pro- and anti-inflammatory T cells in fat tissue is in fact related to macrophage phenotype and insulin resistance, and how it is related.
Read full original descriptionShow less
This study is needed to confirm whether conclusions based on studies of visceral adipose tissue in mice are indeed applicable to humans.
We also want to determine the relationship between insulin resistance/hyperinsulinemia and ability to lose weight in obese individuals.
The group in the trial
- Bariatric Cohort
For consenting subjects who are undergoing bariatric surgery, a visceral fat sample will be taken during surgery. In addition to the fat sample, insulin resistance will be measured and determined by a modification of the insulin suppression test.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Adaptive Immune Response in Visceral and Subcutaneous Fat: Role in Human Insulin Resistance
- Plain-language title
- Studying immune cells in fat tissue and insulin resistance in people with obesityGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT04708535, who can take part
- Record updated
- 13 May 2026