Tests vitamin C effects on blood vessels in adults with obesity
Tests vitamin C in adults with obesity and insulin resistance.
Key facts
- Who runs it
- University of Kansas Medical Center
- Where
- Kansas City, United StatesSee the site
- Trial code
- Registry title
- Sympathetic-vascular Dysfunction in Obesity and Insulin Resistance (Vitamin C Study)
- Status
- Recruiting
- Phase
- Phase 1/2
- People taking part
- 23 people, planned
- Started
- 17 Jun 2021
- Expected to end
- 1 Aug 2027
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Ascorbic acid solution (American Regent Laboratories Inc.)
- Saline
- Record updated
- 8 June 2025
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for obese, middle-aged adults. It studies blood vessel health and nerve activity, and how vitamin C changes blood pressure.
- Age
- 35 to 65 years
- Sex
- All sexes can join.
- Disease stage
- Obese, with a BMI above 30.
- Earlier treatment
- Participants must be willing to stop any vitamin C or E supplements or omega-3 fatty acids, starting 2 weeks before.
Main reasons for not taking part
- Diabetes
- Currently taking a statin or blood pressure medicine
- High blood fats (hyperlipidemia)
- Hypertension
- History of heart disease or vascular disease
The registry criteria, word for word
Show all 10 criteriaShow less
Who can take part
- Obese: BMI >30 m/kg2
- Middle-aged: 35-65 years
- Participants must be willing and able to discontinue taking any vitamin C or E supplements or omega-3 fatty acids beginning 2 weeks prior
- Able and willing to provide written informed consent
Who cannot take part
- Currently taking a statin or antihypertension medication
- Hypertension: <130/80 mmHg
- History of heart disease (e.g., myocardial infarction, stent)
- History of vascular disease (e.g., bypass, stroke)
- Diabetes mellitus: fasting glucose < 1267 mg/dL and/or HbA1c < 6.5%
- Hyperlipidemia: Fasting triglycerides < 250 mg/dL
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 35 and 65 years old?
Where in United States
- University of Kansas Medical CenterKansas City, United StatesContact: Davina ClonchTaking people
About the trial
What the trial wants to find out
The main purpose of research is to examine and understanding the development of hypertension in obese adults with insulin resistance. Findings from our studies will identify unique mechanisms that can be targeted to limit increases in vascular dysfunction and reduce the excessively high prevalence of hypertension and risk for cardiovascular disease (CVD).
Read full original descriptionShow less
This study is testing the health of the blood vessels and the activity of the nerves that control the blood vessels in adults with insulin resistance. The extent to which ascorbic acid (Vitamin C) improves the function of the blood vessels will be determined. The primary outcome is blood pressure, which is the result of blood vessel health and activity of the nerves, and the reduction in blood pressure that is observed with ascorbic acid.
The 2 groups in the trial
- Placebo infusionPlacebo, for comparison
Saline will be administered over 2 hours
Treatment: Saline
- Ascorbic acid infusionExisting treatment, for comparison
Ascorbic acid solution (American Regent Laboratories Inc.) will be obtained from the KU Investigational Pharmacy located in the University of Kansas (KU) Clinical Research Center where studies will take place. A priming bolus of 0.06 g ascorbic acid/kg fat free mass (FFM) dissolved in 100 mL of saline will be infused intravenously at 5 mL/min for 20 minutes, followed immediately by a "drip-infusion" of 0.02 g/kg FFM dissolved in 30 mL of saline administered over 2 hours at 0.5 mL/min.
Treatment: Ascorbic acid solution (American Regent Laboratories Inc.)
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Sympathetic-vascular Dysfunction in Obesity and Insulin Resistance
- Plain-language title
- Tests vitamin C effects on blood vessels in adults with obesityGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT04715022, who can take part
- Record updated
- 8 June 2025