Studies how people's bodies respond to different meals and foods
Tests how adults respond to mixed meals and everyday foods, including diabetes and heart disease.
Key facts
- Who runs it
- Zoe Global Limited
- Where
- Needham, United StatesSee the siteAlso in 1 other country, 1 site
- Trial code
- Registry title
- Personalized Responses to Dietary Composition Trial 3
- Status
- Recruiting
- People taking part
- 250,000 people, planned
- Started
- 20 Jul 2020
- Expected to end
- 1 Jan 2030
- Type of study
- Interventional
- Treatments tested
- Dietary Intervention
- Record updated
- 16 April 2025
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults already enrolled in the commercial ZOE testing program who live in the continental US (not New York) or in the UK. They must be able to follow the study plan.
- Age
- At least 18 years (at least 19 years in Alabama and Nebraska).
- Sex
- Any sex.
Main reasons for not taking part
- Cannot safely eat the pre-made test meals (for example allergy or recent stomach or bowel surgery) or is unwilling to eat them
- Is pregnant
- Had a heart attack, stroke/transient ischemic attack (TIA) or major surgery in the last two months
- Cannot read and write in English
The registry criteria, word for word
Show all 11 criteriaShow less
Who can take part
- Enrolled in the commercial ZOE testing program
- Any sex
- Minimum 18 years of age (minimum 19 years of age in Alabama and Nebraska due to state laws)
- Body mass index (BMI) of greater than or equal to 16.5 kg/m2
- Living in the continental US states, other than in New York (excluded from the ZOE testing product also as they are unable to access the dried blood spot service provided by Quest), or living in the UK
- Able and willing to comply with the study protocol and provide informed consent
- Under care for chronic medical conditions (including eating disorders, type 1 diabetes, type 2 diabetes), and confirm they have checked with their primary care physician that this study is safe for them (US cohort only)
Who cannot take part
- Cannot safely eat the pre-made test meals which contain standard US ingredients, e.g. due to allergy or recent gastrointestinal surgery, or are unwilling to consume these foods
- Have had a heart attack (myocardial infarction), stroke/transient ischemic attack (TIA), or major surgery in the last two months
- Are pregnant
- Are unable to read and write in English, as the ZOE app is only available in English
Where in United States
Also in 1 other country, 1 site
- Zoe US Inc.Needham, United StatesContact: Brad ReardonTaking people
About the trial
What the trial wants to find out
The PREDICT 3 study will build on previous research in over 2,000 individuals to further refine machine learning models that predict individual responses to foods, with the aim of advancing precision nutrition science and individualized dietary advice. The study incorporates both standardized and controlled dietary intervention, for the purpose of testing postprandial responses to specific mixed meals, in addition to a free-living period with a dietary record for measuring responses to a large variety of meals consumed in a realistic context, where the role of external factors (e.g. exercise, sleep, time of day) on postprandial responses may be determined. For the first time this PREDICT study is built on top of a commercial product which will allow access to a much larger group of participants who are already collecting large amounts of data through digital and biochemical devices that can contribute to science.
The group in the trial
- Dietary InterventionTreatment being tested
Dietary intervention using standardized test meals after which the postprandial metabolic response is measured.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Personalized Responses to Dietary Composition Trial 3
- Plain-language title
- Studies how people's bodies respond to different meals and foodsGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 16 April 2025