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NCT04761770Active, not recruitingPhase 2

Study of a Geriatric Assessment to Plan a Treatment Approach for Older People With Various Blood Disorders

Phase II Study of a Geriatric Assessment-Driven, Risk-Adapted Allogeneic Hematopoietic Cell Transplant Strategy for Older Patients With Myeloid Malignancies

Source: ClinicalTrials.gov · Last updated 17 Feb 2026

Brief summary (registry, in English)

This study will evaluate whether a geriatric assessment can lead to better treatment outcomes in older patients (age 60+) with a myeloid malignancy including acute myeloid leukemia, ,myelodysplastic syndromes, myeloproliferative neoplasms, or related blood disorders who are going to receive chemotherapy or another treatment to prepare the body for an allogeneic hematopoietic stem cell transplant (allo-HCT). The geriatric assessment includes looking at patients' cognitive function (thinking processes), physical function, mobility (ability to move the body), mood, nutrition, and current medications to help decide the type of treatment they'll receive. Another purpose of this study is to see whether use of the geriatric assessment improves participants' quality of life. We will evaluate participants' quality of life through questionnaires.

Status (registry)
Active, not recruiting
Phase (registry)
Phase 2
Study type
Interventional
Enrollment
33 (actual)
First submitted
16 Feb 2021
Start date
15 Feb 2021
Primary completion date
Feb 2027
Lead sponsor
Memorial Sloan Kettering Cancer Center
NCT number
NCT04761770

What you commit to

  • Study type: Interventional · Phase 2
  • Participants enrolled: 33
  • From 15 Feb 2021 to the primary completion date, Feb 2027
  • 7 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study design.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Prior hematopoietic cell transplantation
  • Persons with active, refractory disease defined by ≥10% blasts in bone marrow prior to transplant

Other

  • Cord blood donors

Who the study is looking for

  • are 60 years or older
  • have a pathologically confirmed myeloid malignancies including acute myeloid leukemia, ,myelodysplastic syndrome, myeloproliferative neoplasms, or related blood disorders including chronic myelomonocytic leukemia, atypical chronic myeloid leukemia, and myelodysplastic/myeloproliferative overlapping syndrome
  • have \<10% blasts in bone marrow prior to transplant
  • have a matched related or unrelated donor, mismatched unrelated donor, or haploidentical donor
  • Meet institutional standard criteria for allogeneic transplantation as determined by the primary transplant physician
  • Undergoes transplantation using the allocated conditioning regimen intensity defined by the protocol-specified criteria below:
    • HCT-CI/Age \<5 and IADL normal = myeloablative regimen
    • HCT-CI/Age ≥5 and/or IADL impairment = RIC/NMA regimen

Age in the registry: 60 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (7)

Sites in registry order. Save your city in your profile to sort them by distance.

SiteCityCountrySite status
Memorial Sloan Kettering Basking Ridge (Consent Only)
Coordinator of this site? Confirm its status
Basking RidgeUnited StatesUnknown status
Memorial Sloan Kettering Commack (Consent only)
Coordinator of this site? Confirm its status
CommackUnited StatesUnknown status
Memorial Sloan Kettering Westchester (Consent only)
Coordinator of this site? Confirm its status
HarrisonUnited StatesUnknown status
Memorial Sloan Kettering Monmouth (Consent Only)
Coordinator of this site? Confirm its status
MiddletownUnited StatesUnknown status
Memorial Sloan Kettering Bergen (Consent Only)
Coordinator of this site? Confirm its status
MontvaleUnited StatesUnknown status
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
Coordinator of this site? Confirm its status
New YorkUnited StatesUnknown status
Memorial Sloan Kettering Nassau (Consent Only)
Coordinator of this site? Confirm its status
UniondaleUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.