Brain Imaging of Stress and Control in Teen Depression
Studies brain activity during a computer task in teens with major depression.
Plain-language title generated from the registry record
Registry title: Neural Correlates of Stress and Perceived Control in Adolescent Depression
Key facts
- Where
- Belmont, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 14 and 18 years old?
Source: NCT04788524, who can take part
Where in United States
- McLean HospitalBelmont, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Mclean Hospital
- Trial code
- NCT04788524
- Record updated
- 19 May 2026
- Original description
Lack of perceived control, particularly during stress, has been critically implicated in major depressive disorder (MDD) and anhedonic symptoms, especially among female adolescents; yet the neural underpinnings of perceived control disruptions in MDD remain poorly understood. Using functional magnetic resonance imaging with a novel "value of control task" in conjunction with a prospective design, this study will provide a comprehensive understanding of stress and perceived control related mechanisms in female adolescents with MDD and will examine stress-induced disruptions in perceived control as a predictor of "real world" expressions of maladaptive coping and anhedonia.Read full original descriptionShow less
Neural Correlates of Stress and Perceived Control in Adolescent Depression
Lack of perceived control, particularly during stress, has been critically implicated in major depressive disorder (MDD) and anhedonic symptoms, especially among female adolescents; yet the neural underpinnings of perceived control disruptions in MDD remain poorly understood. Using functional magnetic resonance imaging with a novel "value of control task" in conjunction with a prospective design, this study will provide a comprehensive understanding of stress and perceived control related mechanisms in female adolescents with MDD and will examine stress-induced disruptions in perceived control as a predictor of "real world" expressions of maladaptive coping and anhedonia.
Inclusion: Inclusion Criteria: All Participants; Females of all ethnic origins See Section: Inclusion of Women and Minorities); Ages 14-18 (See Section: Inclusion of Children); Written informed assent/consent from adolescent and parent/guardian (if under age 18); English as a first language or English fluency; Right handed111; Personal cell-phone (for Ecological Momentary Assessment [EMA]) 7 All participants will be in the follicular phase of their menstrual cycle when completing the functional magnetic resonance imaging (fMRI) study session; Meet Diagnostic Statistical Manual-5th edition (DSM-5) diagnostic criteria for major depressive disorder (as diagnosed with the KSADS); Absence of any psychotropic medications for at least 2 weeks (6 weeks for fluoxetine; 6 months for neuroleptics; 2 weeks for benzodiazepines; 2 weeks for any other antidepressants); No history or current diagnosis of any DSM-5 psychiatric or substance/alcohol-related disorder (as diagnosed with the KSADS); No first-degree relatives with a history of depression, bipolar disorder, or psychosis.
Exclusion: Major depressive disorder diagnosis secondary to another disorder (selected comorbid anxiety disorders such as generalized anxiety disorder, specific phobia, and social anxiety disorders are allowed if they are secondary to MDD); Exclusion Criteria: All Participants; History of head trauma with loss of consciousness; History of seizure disorder; Serious or unstable medical illness including cardiovascular, hepatic, renal, respiratory, endocrine, neurologic or hematologic disease; History of cocaine or stimulant use (e.g., amphetamine, cocaine, methamphetamine); History of use of dopaminergic drugs (including methylphenidate); Use of hormonal replacement therapy, anabolic steroids, or hormonal contraception; Clinical or laboratory evidence of hypothyroidism; Systemic medical or neurological illness that could impact fMRI measures of cerebral blood flow; Failure to meet standard exclusion criteria for fMRI scanning (e.g., claustrophobia, cardiac pacemakers, neural pacemakers, surgically implanted metal devices, cochlear implants, metal braces, or other metal objects in the body); Pregnancy; Testing positive on a drug test on the day of the scan which testis for stimulants, marijuana, barbiturates, benzodiazepine, buprenorphine, 3,4-Methyl enedioxy methamphetamine (MDMA), methadone, opiates, oxycodone, phencyclidine; History of electroconvulsive therapy; Participants with suicidal ideation where study participation is deemed unsafe by the study clinician; Additional Exclusion Criteria: Major Depressive Disorder (MDD) Sample.