Imaging the Lungs of People With Cystic Fibrosis or Bronchiectasis
Studies lung imaging in people with cystic fibrosis or non-CF bronchiectasis, using xenon gas.
Plain-language title generated from the registry record
Registry title: Regional Phenotyping of CF and Non-CF Bronchiectasis
Key facts
- Where
- Cincinnati, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 5 and 100 years old?
Source: NCT04793867, who can take part
Where in United States
- Penny NewCincinnati, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Children's Hospital Medical Center, Cincinnati
- Trial code
- NCT04793867
- Record updated
- 7 October 2026
- Original description
The Investigators propose to study pediatric subjects who are diagnosed with cystic fibrosis (CF) and patients with non-CF bronchiectasis, with the goal of developing markers of CF lung disease severity, progression, and therapy response. The Investigator's central hypothesis is that image-based markers can forecast pathophysiology prior to spirometric changes.Read full original descriptionShow less
Regional Phenotyping of Cystic Fibrosis Lung Disease and Non-CF Bronchiectasis
The Investigators propose to study pediatric subjects who are diagnosed with cystic fibrosis (CF) and patients with non-CF bronchiectasis, with the goal of developing markers of CF lung disease severity, progression, and therapy response. The Investigator's central hypothesis is that image-based markers can forecast pathophysiology prior to spirometric changes.
Inclusion: CF Patients: Diagnosis of CF based on sweat chloride >60 mMol/l; Presence of two disease causing CFTR mutations, or end organ manifestations of disease; Age minimum 5 years; Care provided by the CCHMC CF Care Center or other regional CF Care Centers if required to achieve recruitment goals; Subjects 5 years of age and older with no known history of cardiopulmonary disease.
Exclusion: Patients meeting standard MRI exclusions criteria (non-MRI-compatible metal implants, claustrophobia, etc.); Patients meeting standard MRI exclusions criteria (non-MRI-compatible metal implants, claustrophobia, etc.); Pregnancy or lactation; Pregnancy or lactation.