Studies heart rhythm treatment after cardiac surgery in atrial fibrillation patients
Observes low-energy cardioversion and pacing in adults with atrial fibrillation after heart surgery.
Plain-language title generated from the registry record
Registry title: The DefiPace Study
Key facts
- Where
- Dresden, Erlangen, Freiburg im Breisgau, Hanover, Jena, Nuremberg, Oldenburg, Ulm, and Würzburg, GermanySee the 9 sites
Where in Germany
- Heart Center Dresden GmbH University HospitalDresden, GermanyTaking people
- Universitätsklinikum ErlangenErlangen, GermanyTaking people
- Albert-Ludwigs-Universitaet FreiburgFreiburg im Breisgau, GermanyTaking people
- Hannover Medical SchoolHanover, GermanyTaking people
- University Hospital JenaJena, GermanyTaking people
- Klinikum NürnbergNuremberg, GermanyTaking people
- Oldenburg Hospital AöR / Medical Campus University of OldenburgOldenburg, GermanyTaking people
- University Hospital UlmUlm, GermanyTaking people
- University Hospital of WürzburgWürzburg, GermanyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Institut für Pharmakologie und Präventive Medizin
- Trial code
- NCT04804748
- Record updated
- 30 July 2026
- Original description
Prospective, non-interventional, multi-center, international registry in two phases in consecutive patients undergoing elective cardiac surgery.Read full original descriptionShow less
Safety and Efficacy of Low-energy Electrical Cardioversion With or Without Bi-atrial Pacing in Patients With Post-operative Atrial Fibrillation in a Real World Setting - The DefiPace Study
Prospective, non-interventional, multi-center, international registry in two phases in consecutive patients undergoing elective cardiac surgery.
The DefiPace registry is designed in two phases
1. to document the standard of care in 50 patients with atrial fibrillation (AF) 2. to assess the treatment and outcomes of patients with post-operative atrial fibrilllation using low-energy cardioversion and subsequent bi-atrial pacing in clinical practice in 100 patients
Inclusion: Patient is scheduled to undergo elective open chest cardiac surgery (bypass and / or valve surgery); Patient is at least 18 years old; Patient with isolated bypass surgery is at least 70 years old; Patient with valve surgery is at least 60 years old; Patient provides written informed consent prior to the procedure; Phase B only: patient is scheduled for TMA implantation during the elective cardiac surgery and is potentially eligible for DefiPace use.
Exclusion: Minimally-invasive surgery; Pregnacy at the time of surgery; Clinical history of either permanent, persistend or paroxysmal atrial fibrillation; Permanent pacemaker/defibrillator, other intra-cardiac active implanted electronic devices; Recent stroke within the last 3 months; A history of or current endocarditis.