Comparing Heart Pressure Tests With PET Scans in Aortic Valve Narrowing
Studies heart artery narrowing tests against PET scans in older adults with aortic valve narrowing.
Plain-language title generated from the registry record
Registry title: Correlation of FFR and iFR With Cardiac PET Perfusion in Patients With Severe Aortic Valve Stenosis
Key facts
- Where
- Bad Oeynhausen, GermanySee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults over 65 with severe aortic valve stenosis who can have a transcatheter aortic valve procedure. They must also have an intermediate narrowing of a heart artery.
- Age
- Over 65 years
- Sex
- All sexes can join
- Disease stage
- Severe aortic valve stenosis, able to have a transcatheter aortic valve procedure, with an intermediate coronary artery narrowing
- Biomarker or test result
- Heart pumping function (left ventricular ejection fraction) above 55%; coronary artery FFR (a pressure test of the artery) above 0.8
Main reasons for not taking part
- Intolerance of adenosine
- Left ventricular ejection fraction below 55%
- History of slow heart rate (bradycardia)
- History of heart block (atrioventricular block)
Read by machine on 12 November 2026.
Where in Germany
- Herz- und Diabeteszentrum NRWBad Oeynhausen, GermanyContact: Tanja K Rudolph, MDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Heart and Diabetes Center North-Rhine Westfalia
- Trial code
- NCT04882488
- Record updated
- 26 November 2024
- Original description
Aortic valve stenosis (AS) affects 2-7% of persons > 65 years, symptoms include: angina and dyspnea, dizziness and syncope. Coincidence of coronary artery disease (CAD), also presenting with angina and dyspnea, in patients with AS between 40 - 65% . Angina in AS caused by significant reduction of coronary flow reserve (CFR). CFR is the ratio of maximal flow increase in the coronary vessel bed during maximal hyperaemia (medically or exercise induced). FFR (fractional flow reserve) use in patients with AS potentially invalid due to dysfunctional CFR leading to potential undertreatment of CAD in these patients.CFR disturbance in AS mainly due to myocardial overload causing concentric hypertrophy, increased oxygen consumption and neurohormonal activation leading to increased vascular resistance. Current studies are investigating the validity of FFR and iFR in AS patients. Recent data demonstrate very good correlation between FFR and iFR derived values to PET myocardial perfusion imaging values in patients with no evidence of AS. Our study aims to investigate the diagnostic performance of FFR and iFR in intermediate-grade coronary stenosis in patients with severe aortic valve disease and correlate FFR- and iFR derived values with those extracted from PET-perfusion Imaging.Read full original descriptionShow less
Correlation of FFR and iFR With Cardiac PET Perfusion (at Rest and Under Adenosine) in the Evaluation of Intermediate Coronary Stenoses in Patients With Severe Aortic Valve Stenosis
Aortic valve stenosis (AS) affects 2-7% of persons > 65 years, symptoms include: angina and dyspnea, dizziness and syncope. Coincidence of coronary artery disease (CAD), also presenting with angina and dyspnea, in patients with AS between 40 - 65% . Angina in AS caused by significant reduction of coronary flow reserve (CFR). CFR is the ratio of maximal flow increase in the coronary vessel bed during maximal hyperaemia (medically or exercise induced). FFR (fractional flow reserve) use in patients with AS potentially invalid due to dysfunctional CFR leading to potential undertreatment of CAD in these patients.CFR disturbance in AS mainly due to myocardial overload causing concentric hypertrophy, increased oxygen consumption and neurohormonal activation leading to increased vascular resistance. Current studies are investigating the validity of FFR and iFR in AS patients. Recent data demonstrate very good correlation between FFR and iFR derived values to PET myocardial perfusion imaging values in patients with no evidence of AS. Our study aims to investigate the diagnostic performance of FFR and iFR in intermediate-grade coronary stenosis in patients with severe aortic valve disease and correlate FFR- and iFR derived values with those extracted from PET-perfusion Imaging.
Inclusion: patients with severe aortic Stenosis eligible for transcatheter aortic stenosis; left ventricular ejection fraction > 55%; no intolerance of Adenosin; no history of bradycardia, atrioventricular Blockade; intermediate coronary Stenosis with FFR> 0.8; Age >65.
Exclusion: left ventricular ejection fraction < 55%; intolerance of Adenosin.