Taking people in United StatesNo phase

PROGRESS: Management of Moderate Aortic Stenosis by Clinical Surveillance or TAVR

Key facts

Where: Atlanta, Austin, Boise, Boston, Buffalo, Chicago, Cincinnati, Clackamas, Columbus, Dallas, Gainesville, Germantown, Greensboro, Houston, Huntsville, Jacksonville, Kansas City, Knoxville, Lebanon, Lisle, Los Angeles, Loveland, McLean, Mineola, Minneapolis, Missoula, Morristown, Nashville, Neptune City, New Brunswick, New Haven, New Orleans, New York, Norfolk, Pasadena, Pittsburgh, Plano, Portland, Rancho Mirage, Ridgewood, Rochester, Roslyn, Saint Cloud, San Antonio, San Francisco, Santa Barbara, Sarasota, Seattle, Stanford, The Bronx, Tucson, Tulsa, Wichita, Wormleysburg, and Wynnewood, United StatesSee the 65 sites

Where in United States

Emory University AtlantaAtlanta, United StatesContact: Edwards THV Clinical AffairsTaking people
Piedmont Heart InstituteAtlanta, United StatesContact: Edwards THV Clinical AffairsTaking people
Ascension Texas CardiovascularAustin, United StatesContact: Edwards THV Clinical AffairsTaking people
Saint AlphonsusBoise, United StatesContact: Edwards THV Clinical AffairsTaking people
Massachusetts General Hospital - BostonBoston, United StatesContact: Edwards THV Clinical AffairsTaking people
University of Buffalo / Kaleida HealthBuffalo, United StatesContact: Edwards THV Clinical AffairsTaking people
Rush University Medical CenterChicago, United StatesContact: Edwards THV Clinical AffairsTaking people
The Christ HospitalCincinnati, United StatesContact: Edwards THV Clinical AffairsNo longer taking part
Kaiser Permanente NorthwestClackamas, United StatesContact: Edwards THV Clinical AffairsNo longer taking part
Mount Carmel Health SystemColumbus, United StatesContact: Edwards THV Clinical AffairsNo longer taking part
UT Southwestern Medical CenterDallas, United StatesContact: Edwards THV Clinical AffairsTaking people
The Cardiac & Vascular Institute Research FoundationGainesville, United StatesContact: Edwards THV Clinical AffairsNo longer taking part
Baptist Memorial Hospital MemphisGermantown, United StatesContact: Edwards THV Clinical AffairsTaking people
Methodist Le Bonheur HealthcareGermantown, United StatesContact: Edwards THV Clinical AffairsTaking people
Moses Cone Memorial HospitalGreensboro, United StatesContact: Edwards THV Clinical AffairsTaking people
HCA Houston Healthcare Medical CenterHouston, United StatesContact: Edwards THV Clinical AffairsTaking people
The University of Texas Health Science CenterHouston, United StatesContact: Edwards THV Clinical AffairsTaking people
Heart Center LLC, HuntsvilleHuntsville, United StatesContact: Edwards THV Clinical AffairsTaking people
Baptist Health Research CenterJacksonville, United StatesContact: Edwards THV Clinical AffairsTaking people
Saint Luke's Hospital of Kansas City Mid AmericaKansas City, United StatesContact: Edwards THV Clinical AffairsTaking people
Parkwest Medical CenterKnoxville, United StatesContact: Edwards THV Clinical AffairsTaking people
Mary Hitchcock Memorial HospitalLebanon, United StatesContact: Edwards THV Clinical AffairsTaking people
Alexian Brothers HospitalLisle, United StatesContact: Edwards THV Clinical AffairsTaking people
Cedars-Sinai Medical CenterLos Angeles, United StatesContact: Edwards THV Clinical AffairsTaking people
UC Health Medical Center of the RockiesLoveland, United StatesContact: Edwards THV Clinical AffairsTaking people
Kaiser Mid AtlanticMcLean, United StatesContact: Edwards THV Clinical AffairsTaking people
NYU Langone Hospital - Long IslandMineola, United StatesContact: Edwards THV Clinical AffairsTaking people
Minneapolis Heart Institue, St. Paul'sMinneapolis, United StatesContact: Edwards THV Clinical AffairsTaking people
St. Patrick HospitalMissoula, United StatesContact: Edwards THV Clinical AffairsNo longer taking part
Atlantic Health System Hospital Corp - Morristown Medical CenterMorristown, United StatesContact: Edwards THV Clinical AffairsTaking people
Saint Thomas HealthNashville, United StatesContact: Edwards THV Clinical AffairsTaking people
Vanderbilt University Medical CenterNashville, United StatesContact: Edwards THV Clinical AffairsTaking people
Jersey Shore University Medical CenterNeptune City, United StatesContact: Edwards THV Clinical AffairsTaking people
Rutgers, Robert Wood Johnson Medical SchoolNew Brunswick, United StatesContact: Edwards THV Clinical AffairsTaking people
Yale UniverstiyNew Haven, United StatesContact: Edwards THV Clinical AffairsTaking people
Louisiana State UniversityNew Orleans, United StatesContact: Edwards THV Clinical AffairsTaking people
Ochsner Clinical FoundationNew Orleans, United StatesContact: Edwards THV Clinical AffairsNo longer taking part
Columbia University Irving Medical Center/NYPHNew York, United StatesContact: Edwards THV Clinical AffairsNo longer taking part
NYU Langone HealthNew York, United StatesContact: Edwards THV Clinical AffairsNo longer taking part
Sentara Norfolk General HospitalNorfolk, United StatesContact: Edwards THV Clinical AffairsTaking people
Huntington HospitalPasadena, United StatesContact: Edwards THV Clinical AffairsNo longer taking part
Allegheny-Singer Research InstitutePittsburgh, United StatesContact: Edwards THV Clinical AffairsTaking people
UPMC Presbyterian ShadysidePittsburgh, United StatesContact: Edwards THV Clinical AffairsNo longer taking part
The Heart Hospital Baylor PlanoPlano, United StatesContact: Edwards THV Clinical AffairsTaking people
Legacy Emanuel Medical CenterPortland, United StatesContact: Edwards THV Clinical AffairsTaking people
Providence Heart & Vascular Institute PortlandPortland, United StatesContact: Edwards THV Clinical AffairsNo longer taking part
Eisenhower Desert Cardiology CenterRancho Mirage, United StatesContact: Edwards THV Clinical AffairsTaking people
The Valley HospitalRidgewood, United StatesContact: Edwards THV Clinical AffairsTaking people
Rochester General HospitalRochester, United StatesContact: Edwards THV Clinical AffairsTaking people
St. Francis HospitalRoslyn, United StatesContact: Edwards THV Clinical AffairsTaking people
Centracare Heart and Vascular CenterSaint Cloud, United StatesContact: Edwards THV Clinical AffairsTaking people
Methodist Hospital of San AntonioSan Antonio, United StatesContact: Edwards THV Clinical AffairsNo longer taking part
Bay Area Structural Heart at Sutter HealthSan Francisco, United StatesContact: Edwards THV Clinical AffairsTaking people
University of California San FranciscoSan Francisco, United StatesContact: Edwards THV Clinical AffairsTaking people
Kaiser San Francisco Medical CenterSan Francisco, United StatesContact: Edwards THV Clinical AffairsNo longer taking part
Santa Barbara Cottage HospitalSanta Barbara, United StatesContact: Edwards THV Clinical AffairsTaking people
Sarasota Memorial Health Care SystemSarasota, United StatesContact: Edwards THV Clinical AffairsTaking people
Swedish Medical CenterSeattle, United StatesContact: Edwards THV Clinical AffairsTaking people
Stanford UniveristyStanford, United StatesContact: Edwards THV Clinical AffairsTaking people
Montefiore Medical CenterThe Bronx, United StatesContact: Edwards THV Clinical AffairsTaking people
Tucson Medical CenterTucson, United StatesContact: Edwards THV Clinical AffairsNo longer taking part
Oklahoma Heart InstituteTulsa, United StatesContact: Edwards THV Clinical AffairsTaking people
Ascension Via Christi St. FrancisWichita, United StatesContact: Edwards THV Clinical AffairsTaking people
Pinnacle Health HarrisburgWormleysburg, United StatesContact: Edwards THV Clinical AffairsNo longer taking part
Lankenau Medical CenterWynnewood, United StatesContact: Edwards THV Clinical AffairsTaking people

Questions to ask the study team

How often do I need to come in, and for how long each time?
Are travel costs paid?
Can I keep my own doctor?
What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Trial details

Who runs it: Edwards Lifesciences
Trial code: NCT04889872
Record updated: 17 December 2025
Original description: This study objective is to establish the safety and effectiveness of the Edwards SAPIEN 3 / SAPIEN 3 Ultra / SAPIEN 3 Ultra RESILIA Transcatheter Heart Valve systems in subjects with moderate, calcific aortic stenosis.Read full original descriptionShow less
The PROGRESS Trial: A Prospective, Randomized, Controlled Trial to Assess the Management of Moderate Aortic Stenosis by Clinical Surveillance or Transcatheter Aortic Valve Replacement
This study objective is to establish the safety and effectiveness of the Edwards SAPIEN 3 / SAPIEN 3 Ultra / SAPIEN 3 Ultra RESILIA Transcatheter Heart Valve systems in subjects with moderate, calcific aortic stenosis.
Following completion of enrollment, subjects will be eligible for enrollment in the continued access phase of the trial.
Inclusion: 65 years of age or older at time of randomization; Moderate aortic stenosis; Subject has symptoms or evidence of cardiac damage/dysfunction; The subject or subject's legal representative has been informed of the nature of the study, agrees to its provisions, and has provided written informed consent.
Exclusion: Prior balloon aortic valvuloplasty to treat severe AS; Cardiac imaging evidence of intracardiac mass, thrombus, or vegetation; LVEF < 20%; Native aortic annulus size unsuitable for the THV; Anatomical characteristics that would preclude safe transfemoral placement of the introducer sheath or safe passage of the delivery system; Aortic valve is unicuspid or non-calcified; Bicuspid aortic valve with an aneurysmal ascending aorta > 4.5 cm or severe raphe/leaflet calcification; Pre-existing mechanical or bioprosthetic aortic valve; Severe aortic regurgitation; Left ventricular outflow tract calcification that would increase the risk of annular rupture or significant paravalvular leak post-TAVR; Coronary or aortic valve anatomy that increases the risk of coronary artery obstruction post-TAVR.
ClinicalTrials.gov NCT04889872