Aortic stenosis trials in United States

In United States 42 Also abroad 232

42 trials · From ClinicalTrials.gov, checked 13 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Trial of the F2 Filter and Delivery System for Embolic Protection During TAVR
Where
Charlottesville, Cleveland, Columbus, Detroit, Indianappolis, Kansas City, Naples, New York
Age
21 years to 90 years
People
500 worldwide
Run by
EnCompass Technologies, Inc.
See details and how to joinNCT06689839
No phaseNot yet taking people in United States
Importance of Point-of-Care Ultrasound for Early Detection of Valvular and Cardiac Diseases (IMPROVE)
Where
Dallas
Age
65 years to 85 years
People
1,088
Run by
University of Texas Southwestern Medical Center
See details and how to joinNCT07756398
No phaseTaking people
Society of Thoracic Surgeons and American College of Cardiology Transcatheter Valve Therapy Registry (STS/ACC TVT Registry™): Registry Purpose and Research Objective
Where
Washington D.C.
Age
18 years and over
People
50,000
Run by
American College of Cardiology
See details and how to joinNCT07908355
No phaseTaking people
ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves
Where
Atlanta, Baltimore, Boston, Buffalo, Charlotte, Cincinnati, Clackamas, Cleveland, Detroit, Evanston, Houston, Lisle, Loveland, Morristown, Naples, Nashville, New Brunswick, Newport Beach, New York, Pittsburgh, Plano, Ridgewood, Rochester, San Francisco, Seattle, Stanford, Tulsa, Wichita
People
200 worldwide
Run by
Edwards Lifesciences
See details and how to joinNCT05172973
No phaseEnrolling by invitation
Deep Learning Enhanced Detection of Aortic Stenosis - The DETECT-AS-Diagnostic Study
Where
Houston, New Haven, New York
Age
70 years and over
People
410
Run by
Yale University
See details and how to joinNCT06749145
No phaseEnrolling by invitation
Promoting Shared Decision Making for Severe Aortic Stenosis
Where
Atlanta, Aurora, Boston, Chapel Hill, Dallas, Philadelphia, San Francisco, St Louis
Age
65 years to 85 years
People
1,300
Run by
Massachusetts General Hospital
See details and how to joinNCT06171737
No phaseTaking people
ALLIANCE: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve
Where
Atlanta, Baltimore, Boston, Buffalo, Carmel, Charlotte, Chicago, Cincinnati, Clackamas, Cleveland, Dallas, Detroit, Elk Grove Village, Evanston, Germantown, Harrisburg, Hartford, Houston, Kansas City, La Jolla, Lebanon, Los Angeles, Loveland, Missoula, Morristown, Nashville, New Brunswick, New Lenox, Newport Beach, New York, Norfolk, North Naples, Oklahoma City, Pittsburgh, Plano, Portland, Ridgewood, Rochester, Sacramento, Saint Cloud, San Francisco, Seattle, Stanford, St Louis, Tulsa, Wichita
People
1,234 worldwide
Run by
Edwards Lifesciences
See details and how to joinNCT05172960
No phaseTaking people
REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE
Where
Allentown, Ann Arbor, Austin, Baltimore, Birmingham, Boston, Buffalo, Burlington, Charlottesville, Cincinnati, Clearwater, Cleveland, Columbus, Des Moines, Detroit, Falls Church, Fort Myers, Fort Wayne, Grand Rapids, Hartford, Houston, Indianapolis, Iowa City, Kansas City, Lebanon, Los Angeles, Loveland, Manchester, Manhasset, Mechanicsburg, Milwaukee, Minneapolis, Missoula, Nashville, Neptune City, New Haven, New York, Norfolk, Oklahoma City, Orlando, Paramus, Phoenix, Pittsburgh, Portland, Rochester, Roslyn, Sacramento, Saint Cloud, San Antonio, Spokane, Stanford, Tampa, The Bronx, Thousand Oaks, Tucson, Washington D.C., Wichita, Winston-Salem, Wynnewood
Age
18 years to 105 years
People
225
Run by
Medtronic Cardiovascular
See details and how to joinNCT06777368
No phaseTaking people
CardioHeartConnect: Commercially Available Fitness for Cardiac Rehabilitation
Where
Aurora
Age
18 years and over
People
200
Run by
University of Colorado, Denver
See details and how to joinNCT07008911
No phaseEnrolling by invitation
ECG-based AI Screening for Cases of Undiagnosed Moderate-to-Severe Aortic Stenosis in the Primary Care Setting
Where
Orange
Age
65 years and over
People
4,000
Run by
AccurKardia, Inc.
See details and how to joinNCT07827105
No phaseEnrolling by invitation
ENVISION IDE Trial: Safety and Effectiveness of NAVITOR in Transcatheter Aortic Valve Implantation
Where
Albuquerque, Ann Arbor, Asheville, Atlanta, Atlantis, Austin, Baltimore, Birmingham, Boston, Camden, Charleston, Charlottesville, Chicago, Cincinnati, Cleveland, Columbus, Dallas, Denver, Detroit, Englewood, Evanston, Fontana, Gainesville, Greenville, Honolulu, Houston, Indianapolis, Kalamazoo, Kansas City, La Jolla, Largo, Little Rock, Mechanicsburg, Memphis, Miami, Midland, Milwaukee, Morgantown, Morristown, Naples, Nashville, New Brunswick, New Orleans, New York, Norfolk, Ocala, Orlando, Philadelphia, Phoenix, Pittsburgh, Plano, Pomona, Portland, Rochester, Roslyn, San Francisco, Seattle, Sioux Falls, Stanford, St. George, Tallahassee, Thousand Oaks, Tucson, Tulsa, Washington D.C., Wichita, Worcester, Wynnewood
Age
18 years and over
People
1,500 worldwide
Run by
Abbott Medical Devices
See details and how to joinNCT05932615
No phaseTaking people
Home-Based Cardiac Rehabilitation Using a Novel Mobile Health Exercise Regimen Following Transcatheter Heart Valve Interventions
Where
Nashville
Age
18 years and over
People
240
Run by
Vanderbilt University Medical Center
See details and how to joinNCT06077201
No phaseTaking people
CAPTURE-2: Controlled Arterial Protection to Ultimately Remove Embolic Material
Where
Ann Arbor, Asheville, Clearwater, New Orleans, Rapid City, San Antonio, Thousand Oaks
Age
22 years and over
People
663
Run by
EmStop Inc
See details and how to joinNCT07276711
No phaseTaking people
Improved Outcomes With Pre-Procedure Shockwave IVL of Common Femoral Artery Access Site Prior to Large Bore Access and Pre-Closure
Where
Knoxville
Age
18 years and over
People
100
Run by
University of Tennessee Graduate School of Medicine
See details and how to joinNCT07205068
No phaseTaking people
TAVR vs SAVR in Severe Bicuspid Aortic Stenosis
Where
Los Angeles
Age
50 years and over
People
1,200
Run by
Cedars-Sinai Medical Center
See details and how to joinNCT07413965
No phaseTaking people
Study of the Progression of Chronic Cardiovascular Conditions
Where
Chicago
Age
18 years and over
People
5,000
Run by
Prolaio
See details and how to joinNCT07420907
Phase 3Taking people
Study to Evaluate Safety, Tolerability and Efficacy of Inclisiran in Children With Homozygous Familial Hypercholesterolemia
Where
Salt Lake City, San Francisco, St Louis, Washington D.C.
Age
2 years to 11 years
People
9 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT06597006
Phase 2/3Taking people
Ataciguat for Slowing the Progression of Moderate Calcific Aortic Valve Stenosis: A Randomized, Placebo Controlled Study
Where
Albany, Atlantis, Austin, Baltimore, Beverly Hills, Birmingham, Boston, Browns Mills, Buffalo, Camden, Chicago, Cincinnati, Cleveland, Dallas, Durham, Elk Grove Village, Elkhart, Fargo, Glenview, Greensboro, Hialeah, Hollywood, Houston, Huntsville, Jacksonville, Kankakee, Lancaster, Los Angeles, Louisville, Maplewood, Marietta, Miami, Moline, Morristown, Mullica Hill, Naperville, Naples, Nashville, Newburgh, Newport Beach, Pasadena, Peoria, Philadelphia, Phoenix, Pittsburgh, Plano, Portland, Rochester, Rock Hill, Royal Oak, Saint Augustine, Salt Lake City, San Antonio, San Francisco, Sarasota, St Louis, Sugar Land, Tampa, The Bronx, Toledo, Torrance, Tulsa, Vineland, West Bloomfield
Age
50 years and over
People
1,276 worldwide
Run by
Kardigan, Inc.
See details and how to joinNCT07001800 · EU 2025-522176-86-01
Phase 2Taking people
A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis
Where
Albany, Beverly Hills, Boca Raton, Boston, Bradenton, Cincinnati, Columbus, Covina, Detroit, Falls Church, Flint, Houston, Huntsville, Manassas, Miami, Miami Lakes, Minneapolis, Naples, New York, Northridge, Overland Park, Palo Alto, Philadelphia, Rochester, Royal Oak, San Diego, San Francisco, Summit, Winston-Salem
Age
50 years to 80 years
People
502 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT05646381 · EU 2022-502135-19-00
Phase 3Taking people
Study to Evaluate Efficacy and Safety of Inclisiran in Children With Heterozygous Familial Hypercholesterolemia
Where
Boca Raton, Morgantown, New York, Richmond, Salt Lake City, San Francisco, Washington D.C.
Age
6 years to 11 years
People
60 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT06597019
No phaseEnrolling by invitation
Deep Learning-enhanced Personalized Monitoring of Aortic Stenosis - The DETECT-AS Prognostic Study
Where
Houston, New Haven, New York
Age
65 years and over
People
210
Run by
Yale University
See details and how to joinNCT06749132
No phaseTaking people
Correlation Between an Impedance Cardiography Test for Decompensation and the Development of Left Ventricular Replacement Fibrosis
Where
Chicago
Age
18 years and over
People
6
Run by
Dermed Diagnostics, Inc.
See details and how to joinNCT07230964
Phase 4Taking people
Patient Quality of Recovery After TAVR With Different Sedation Regimens
Where
Glenview
Age
18 years to 90 years
People
126
Run by
David Lyubashevsky
See details and how to joinNCT07556523
No phaseTaking people
DELINEATE-Prospective
Where
New York
Age
18 years and over
People
50
Run by
Columbia University
See details and how to joinNCT07197736
No phaseTaking people
Detecting Changes in Arterial Blood Volume and Cardiac Efficiency
Where
Boulder
Age
18 years to 80 years
People
20
Run by
HemoCept Inc.
See details and how to joinNCT07205341