Taking people in ItalyNo phase
PRP Versus HA IN OSTEOARTHRITIS OF THE PATELLOFEMORAL JOINT
Key facts
- Who runs it
- Istituto Ortopedico Rizzoli
- Where
- Bologna, ItalySee the site
- Trial code
- Status
- Recruiting
- People taking part
- 166 people, planned
- Started
- 26 Oct 2022
- Planned end
- Sept 2026
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Autologous PRP injection
- HA injection
- Record updated
- 4 December 2025
Who can take part
- Age
- 30 years to 65 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 23 criteriaShow less
Who can take part
- Age between 30 and 65
- Signs and symptoms of isolated patellofemoral osteoarthritis present in one or both knees
- Radiographic signs of isolated patellofemoral osteoarthritis (according to Iwano et al stage 1-3 classification) or chondropathy (assessed on MRI) with K-L grade of the other compartments ≤ 2. [PMID: 2302884 - PMID: 27979409]
- Hemoglobin > 11 g/dl; Platelet count > 150,000 plt/mm3 (Recently performed CBC exam)
- No clinically significant electrocardiographic alterations (Recently performed ECG)
- Ability and consent of patients to actively participate in clinical follow-up
- Signature of informed consent
Who cannot take part
- Patients who have undergone intra-articular infiltration of another substance within the previous 6 months
- Patients undergoing knee surgery within the previous 12 months
- Patients on anticoagulant-antiaggregant therapy
- Patients abusing alcoholic beverages, drugs or medications
- Patients who have taken NSAIDs in the 3 days prior to blood draw
- Previous treatment of patellar dislocation
- Patients with malignant neoplasms
- Patients with rheumatic diseases
- Patients with diabetes
- Patients with hematologic diseases (coagulopathies)
- Patients with thyroid metabolic disorders
- Patients with cardiovascular disease for which a 60 mL blood draw would be contraindicated
- Patients with a recently performed blood test with Hb< 11 g/dl and Platelets < 150,000 plt/mm3
- Patients unable to express consent
- Body Mass Index > 35
- Iwano score of grade 4
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 30 and 65 years old?
Where in Italy
- Istituto Ortopedico RizzoliBologna, ItalyContact: Alessandro Di Martino, MDTaking people
About the trial
What the trial wants to find out
The aim of the study is to compare the 12-month clinical outcomes of patients with patellofemoral osteoarthritis undergoing infiltrative treatment with fresh PRP and HA
The 2 groups in the trial
- Autologous PRP injectionTreatment being tested
This group of patients will be treated with single intra-articular injection of Autologous PRP.
- HA injectionExisting treatment, for comparison
This group of patients will be treated with single intra-articular injection of Hyaluronic Acid (HA)
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- THE USE OF FRESH PRP VS HA IN THE TREATMENT OF OSTEOARTHRITIS OF THE PATELLOFEMORAL JOINT Randomized Controlled Clinical Trial
- Fit questions
- Built from NCT04937998, who can take part
- Record updated
- 4 December 2025