Studying Social Isolation and Loneliness in People With Psychosis or Schizophrenia
Studies how isolation and loneliness relate to brain processes in adults with psychosis or schizophrenia.
Plain-language title generated from the registry record
Registry title: Neurobehavioral Mechanisms of Social Isolation and Loneliness in Serious Mental Illness
Key facts
- Where
- Charlestown, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 55 years old?
Source: NCT04940663, who can take part
Where in United States
- Massachusetts General HospitalCharlestown, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Massachusetts General Hospital
- Trial code
- NCT04940663
- Record updated
- 16 July 2026
- Original description
The proposed research will test the hypothesis that objective social isolation and loneliness are linked to neurobehavioral mechanisms involved in social perception and motivation in individuals with and without serious mental illness. Moreover, it will investigate the specific dynamic interactions among these experiences in daily life and how they, and their neurobehavioral predictors, are linked to day-to-day functioning. The findings of this project could provide novel targets for therapeutics aimed at improving functioning and overall quality of life in individuals with serious mental illnesses, as well as quantitative phenotypes for use in early detection efforts.Read full original descriptionShow less
Neurobehavioral Mechanisms of Social Isolation and Loneliness in Serious Mental Illness
The proposed research will test the hypothesis that objective social isolation and loneliness are linked to neurobehavioral mechanisms involved in social perception and motivation in individuals with and without serious mental illness. Moreover, it will investigate the specific dynamic interactions among these experiences in daily life and how they, and their neurobehavioral predictors, are linked to day-to-day functioning. The findings of this project could provide novel targets for therapeutics aimed at improving functioning and overall quality of life in individuals with serious mental illnesses, as well as quantitative phenotypes for use in early detection efforts.
Inclusion: 18-55 years old; Experienced a psychotic disorder or mood disorder.
Exclusion: A recent change in medication, or an acute symptom presentation; Any neurological disorder or current substance use disorder (during the past 6 months); Standard exclusion criteria for participation in an MRI scan (e.g., presence of metal in the body, claustrophobia, a history of head trauma); Not proficient in English.