Testing Protein Timing and Time-Restricted Eating for Obesity
Tests protein supplements and time-restricted eating in adults with overweight or obesity.
Key facts
- Who runs it
- University of Arkansas, Fayetteville
- Where
- Fayetteville, United StatesSee the site
- Trial code
- Registry title
- Time Restricted Feeding, Muscle, and Metabolism
- Status
- Recruiting
- People taking part
- 90 people, planned
- Started
- 13 Jun 2021
- Planned end
- 30 Dec 2025
- Type of study
- Interventional, 3 groupsOne group gets a placebo (a dummy treatment), for comparison.
- Treatments tested
- Whey protein supplement
- Ketogenic aid
- Control group - time restricted feeding only
- Record updated
- 26 August 2025
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for overweight or obese adults aged 25-50 who live in Northwest Arkansas. It studies time restricted feeding and protein timing.
- Age
- 25-50 years
- Sex
- Women and men can join.
- Disease stage
- Overweight, with a BMI above 25.
- Earlier treatment
- People who tried to lose weight in the last 3 months cannot join. People taking protein or other nutritional supplements that may affect the results cannot join.
Main reasons for not taking part
- Food allergies or dietary restrictions (for example vegetarian or vegan)
- Pregnant or breastfeeding
- Health conditions related to obesity (for example heart disease, diabetes, high blood pressure)
- Medicines for heart disease or type 2 diabetes
- Smoking or vaping, more than 4 alcoholic drinks per week, or fear of needles
The registry criteria, word for word
Show all 15 criteriaShow less
Who can take part
- Resides in Northwest Arkansas
- Age 25-50 years
- BMI > 25
- All ethnicities
- Female and male
Who cannot take part
- Currently taking protein supplements or other nutritional supplements which may interfere with study outcomes
- Food allergies
- Pre-existing health conditions related to obesity (e.g. cardiovascular disease, diabetes, hypertension)
- Prescription medications related to heart disease or type 2 diabetes
- Pregnant or breastfeeding
- Dietary restrictions (e.g. vegetarian, vegan, etc.)
- Trying to lose weight in last 3 months
- Fear of needles
- Smoker or vaping
- Consumes >4 alcoholic beverages per week
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 25 and 50 years old?
Where in United States
- University of ArkansasFayetteville, United StatesContact: Jamie I Baum, PhDTaking people
About the trial
What the trial wants to find out
Effective nutrition strategies for combatting and/or preventing obesity still need to be identified. This has been the case despite the numerous and different approaches that have been taken. Potential targets for combatting/preventing obesity have been identified, but long-term solutions have not emerged. This study uses time restricted feeding to study the role of dietary protein in obesity prevention and/or treatment. The objectives are to determine the role of skeletal muscle mass as a driver of energy-sensing mechanisms and peripheral signals that regulate appetite and energy intake in overweight and obese adults and to determine the effects of protein timing on muscle mass to regulate appetite and energy intake in overweight and obese adults.
The 3 groups in the trial
- TRF-CPlacebo, for comparison
Follows time restricted feeding protocol.
Treatment: Control group - time restricted feeding only
- TRF-PTreatment being tested
Follows time restricted feeding protocol, consumes protein supplement
Treatment: Whey protein supplement
- TRF-STreatment being tested
Follows time restricted feeding protocol, consumes ketogenic supplement
Treatment: Ketogenic aid
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Time Restricted Feeding Intervention for Muscle and Metabolic Health (TRIMM)
- Plain-language title
- Testing Protein Timing and Time-Restricted Eating for ObesityGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT04949451, who can take part
- Record updated
- 26 August 2025