Relationship Between Gut Microbiome, Probiotics, and Mild Cognitive Impairment

Who can take part

• Patients who is suffering from Mild Cognitive Impairment
• Clinical Dementia Rating (CDR) 0.5
• Age 40-80 and willing to sign the Informed Consent
• Education level is above the junior high school level
• Healthy control who is eligible judged by PI

Who cannot take part

• Have undergone surgery of liver, bladder, or gastrointestinal tract
• Have current or history of inflammatory bowel disease
• Have history of cancer
• Known allergy to probiotics
• Dementia (MMSE ≤ 23)
• Cognitive Impairment caused by head injury
• History of cerebral apocalypse
• Other possible diseases may cause cognitive impairment, such as: Parkinson's disease, cervical mass, hydrocephalus or epilepsy
• Undergoing medication treatment for acute illness, Organic psychosis or diagnosed as psychiatric illness within 3 months or poor control of chronic psychiatric illness
• Patients on antibiotics within the preceding one month
• Patients using of other probiotic products (sachet, capsule or tablet) within the preceding two weeks
• Severely depressed patients (sick person health questionnaire-9 (PHQ-9) ≥ 20)
• Severe anxiety patients (Generalized Anxiety Dosorder 7-Item (GAD-7) ≧ 15)
• Undergoing parenteral nutrition
• Not eligible judged by PI