Taking people in United StatesEarly phase 1

Imaging CRF X NOP Interactions in CUD

Key facts

Who runs it: Rajesh Narendran
Where: Pittsburgh, United StatesSee the site
Trial code: NCT05008146
Status: Recruiting
Phase: Early phase 1
People taking part: 80 people, planned
Started: 31 Dec 2020
Expected to end: 1 Sept 2028
Type of study: Interventional
Treatments tested: Baseline [C-11]NOP-1A PET Scan
Hydrocortisone
Post-hydrocortisone [C-11]NOP-1A PET Scan
Record updated: 6 July 2026

Who can take part

Age: 18 years to 55 years
Sex: Women and men
Healthy volunteers: Can take part

The registry criteria, word for word

Show all 13 criteriaShow less

Other criteria

Cocaine use disorders (CUD)
Males or females between 18 and 55 years old
Fulfil DSM-5 criteria for cocaine use disorder
No other current DSM-5 psychiatric or addictive disorders (such as major depressive disorder, bipolar disorders, psychotic disorders, etc.,)
No current abuse (six months) of opiates, sedative-hypnotics, amphetamines, MDMA, etc., as well as moderate to severe alcohol or cannabis use (twice a week). Nicotine use will be quantified and controlled between groups using the Fagerstrom Test for Nicotine Dependence (Heatherton et al., 1991)
Not currently on prescription medical or psychotropic medications
No current or past severe medical, endocrine or neurological illnesses including glaucoma, seizure disorders, hypertension, hypercholesterolemia as assessed by a complete medical history and physical
Not currently pregnant or breastfeeding
No history of significant radioactivity exposure in past year from another research study or occupation that exceeds RDRC guidelines
No metallic objects in the body that are contraindicated for MRI; Healthy Controls (HC)
Males or females between 18 and 55 years old
No present or past DSM-5 disorders (other than nicotine dependence)
Criteria 5 to 9 as listed previously

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

Are you between 18 and 55 years old?

Where in United States

University of PittsburghPittsburgh, United StatesContact: Rajesh NarendranTaking people

About the trial

What the trial wants to find out

This study uses [11C]NOP-1A positron emission tomography (PET) and a hydrocortisone challenge to image the interaction between nociceptive opioid peptide (NOP) receptors and cortisol/corticotrophin releasing factor (CRF) in subjects with cocaine use disorders (CUD) and matched healthy controls (HC). It will also examine whether alterations in CRF x NOP interactions predict relapse in subjects with CUD.