Frontlight ResearchEarly access
Taking people in United StatesEarly phase 1
[C-11]NPA PET-amphetamine in Cocaine Use Disorders
Key facts
- Who runs it
- Rajesh Narendran
- Where
- Pittsburgh, United StatesSee the site
- Trial code
- Status
- Recruiting
- Phase
- Early phase 1
- People taking part
- 30 people, planned
- Started
- 31 Jan 2021
- Expected to end
- 1 Sept 2028
- Type of study
- Interventional
- Treatments tested
- Baseline [C-11]NPA PET Scan
- d-amphetamine
- Post-amphetamine [C-11]NPA PET Scan
- Record updated
- 6 July 2026
Who can take part
- Age
- 18 years to 55 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 13 criteriaShow less
Who can take part
- Males or females between 18 and 55 years old
- Fulfil DSM-5 criteria for cocaine use disorder
- No other current DSM-5 psychiatric or addictive disorders (such as major depressive disorder, bipolar disorders, psychotic disorders, etc.,)
- No current abuse (six months) of opiates, sedative-hypnotics, amphetamines, and MDMA as well as moderate to severe alcohol or cannabis use (twice a week). Nicotine use will be quantified and controlled between groups using the Fagerstrom Test for Nicotine Dependence (Heatherton et al., 1991)
- Not currently on prescription medical or psychotropic medications
- No current or past severe medical, endocrine or neurological illnesses including glaucoma, seizure disorders, hypertension, hypercholesterolemia as assessed by a complete medical history and physical
- Not currently pregnant or breastfeeding
- No history of significant radioactivity exposure in past year from another research study or occupation that exceeds RDRC guidelines
- No metallic objects in the body that are contraindicated for MRI
- No baseline BP ≥ 140/90 and/or HR ≥ 100
- No first-degree relative with an MI or stroke prior to middle age
- No first-degree relative with psychosis or mania
- Completed a baseline [11C]NOP-1A PET scan in Aim 1 (Study Record: Imaging CRF X NOP interactions in Cocaine Use Disorders)
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 55 years old?
Where in United States
- University of PittsburghPittsburgh, United StatesContact: Rajesh NarendranTaking people
About the trial
What the trial wants to find out
This study uses [11C]NPA positron emission tomography (PET) and a d-amphetamine challenge to image amphetamine induced dopamine release in the striatum in subjects with cocaine use disorders (CUD). Amphetamine-induced dopamine release data from this study will be correlated with [11C]NOP-1A VT measured at baseline in the midbrain. [11C]NOP-1A PET data will be used from aim 1 (see, Study Record: Imaging CRF X NOP interactions in Cocaine Use Disorders)
The group in the trial
- PETTreatment being tested
\[C-11\]NPA PET Scan
Treatment: Baseline [C-11]NPA PET Scan, d-amphetamine, and Post-amphetamine [C-11]NPA PET Scan
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- [C-11]NPA PET-amphetamine in Cocaine Use Disorders (Aim 2)
- Fit questions
- Built from NCT05011760, who can take part
- Record updated
- 6 July 2026