PSMA Scan Guided Treatment After Prostate Surgery Relapse
Studies adults whose prostate cancer returned after surgery, using a PSMA scan to guide treatment.
Plain-language title generated from the registry record
Registry title: PSMA Guided Approach for bIoCHEmical Relapse After Prostatectomy-PSICHE
Key facts
- Where
- Florence, ItalySee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for men whose PSA has started to rise again after surgery to remove the prostate for prostate cancer. They have a PSMA-PET/CT scan to guide further treatment.
- Age
- Older than 18 years
- Sex
- Men only
- Disease stage
- Prostate adenocarcinoma with a PSA rise after prostate removal surgery (PSA above 0.2 and below 1)
- Earlier treatment
- Must have had prostate removal surgery. Radiotherapy to the prostate area after surgery is allowed but not required. Cannot have had hormone therapy (ADT) in the 6 months before joining.
- Biomarker or test result
- PSA above 0.2 and below 1; the PSA was not persistently above 0.1 ng/ml when measured within 16 weeks of surgery
Main reasons for not taking part
- Hormone therapy (ADT) within 6 months before joining
- PSA still above 0.1 ng/ml within 16 weeks after surgery (persistent PSA)
Read by machine on 12 November 2026.
Where in Italy
- AOU Careggi Radiation Oncology UnitFlorence, ItalyContact: Lorenzo Livi, Prof.Taking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Azienda Ospedaliero-Universitaria Careggi
- Trial code
- NCT05022914
- Record updated
- 26 August 2021
- Original description
This observational study was designed to evaluate progression free survival after PSMA-PET/CT based salvage approach for patients affected by biochemical relapse after radical prostatectomy.Read full original descriptionShow less
Prostate-Specific Membrane Antigen (PSMA) Guided Approach for bIoCHEmical Relapse After Prostatectomy- A Prospective Observational Study-PSICHE
This observational study was designed to evaluate progression free survival after PSMA-PET/CT based salvage approach for patients affected by biochemical relapse after radical prostatectomy.
Inclusion: Signed informed consent; Age >18; Patient suitable for 68Ga-PSMA PET/CT re-staging according to clinical practice (Previous radical prostatectomy with histological result of Prostate adenocarcinoma +/- postoperative prostate bed radiotherapy (adjuvant or salvage setting), with a biochemical relapse defined as a PSA > 0.2 and <1.
Exclusion: Persistent elevation of PSA after RP measured within 16 weeks from surgery (> 0.1 ng/ml); ADT administration within 6 months from study enrollment.