Compares two blood sugar targets in pregnant women with gestational diabetes
Tests stricter versus standard blood sugar goals in overweight pregnant women with gestational diabetes.
Plain-language title generated from the registry record
Registry title: Intensive Glycemic Targets in Overweight and Obese Women With Gestational Diabetes
Key facts
- Where
- Birmingham, Indianapolis, Norman, Pittsburgh, and Providence, United StatesSee the 5 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 45 years old?
Source: NCT05124808, who can take part
Where in United States
- University of Alabama at BirminghamBirmingham, United StatesTaking people
- Indiana UniversityIndianapolis, United StatesTaking people
- University of OklahomaNorman, United StatesTaking people
- University of PittsburghPittsburgh, United StatesTaking people
- Women and Infants Hospital of Rhode IslandProvidence, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Indiana University
- Trial code
- NCT05124808
- Record updated
- 16 October 2026
- Original description
This is a multicenter randomized clinical trial of 828 overweight and obese individuals with gestational diabetes designed to compare standard to intensive glycemic targets.Read full original descriptionShow less
Intensive Glycemic Targets in Overweight and Obese Women With Gestational Diabetes Mellitus: A Multicenter Randomized Trial
This is a multicenter randomized clinical trial of 828 overweight and obese individuals with gestational diabetes designed to compare standard to intensive glycemic targets.
Inclusion: Pregnant women between the ages of 18-45; Singleton gestation; Gestational age between 12 0/7-32 6/7 weeks' gestation with gestational diabetes diagnosed during this time frame using either a 50g 1-hr GCT ≥200 mg/dL or two or more abnormal values on a 100g OGTT using the Carpenter-Coustan Criteria; Overweight or obese BMI at the first prenatal visit (BMI ≥25 kg/m2 or ≥23 kg/m2 in Asian Americans).
Exclusion: Significant fetal anomalies diagnosed prior to study enrollment (these will include anomalies such as gastroschisis, spina bifida, complex congenital heart disease, or serious karyotypic anomalies that may lead to early delivery or increased risk of neonatal death); Oral or IV/IM steroid use within 7 days of study enrollment; Known renal disease with a baseline creatinine >1.5 mg/dL; Inability or unwillingness to provide informed consent; Inability to communicate with members of the study team, despite the presence of an interpreter; Planned delivery at a non-study affiliated hospital.