NCT05147701RecruitingPhase 1
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Exosomes for NAION
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Exosomes for the Treatment of Non-arteritic Ischemic Optic Neuropathy
Source: ClinicalTrials.gov · Last updated 16 Oct 2026
Brief summary (registry, in English)
This trial will study the safety and efficacy of intranasal delivery of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes for the treatment of non-arteritic ischemic optic neuropathy
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 20 (estimated)
- First submitted
- 29 Nov 2021
- Start date
- 1 Feb 2022
- Primary completion date
- Jan 2028
- Lead sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
- NCT number
- NCT05147701
What you commit to
- Study type: Interventional · Phase 1
- Planned participants: 20
- From 1 Feb 2022 to the primary completion date, Jan 2028
- 2 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Continued drug abuse
- Previous organ transplant
Other illness
- Active infection
- Active cancer
- Chronic multisystem organ failure
- Medical condition that would (based on the opinion of the investigator) compromise patient's safety.
- Hypersensitivity to sulfur
Lab values
- Clinically significant Abnormalities on pre-treatment laboratory evaluation
Other
- Pregnancy
- Pre-menopausal women not using contraception
Who the study is looking for
- Diagnosis of NAION (non-arteritic ischemic optic neuropathy)
- Understanding and willingness to sign a written informed consent document
Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Prodromos Stem Cell Institute Coordinator of this site? Confirm its status | Athens | Greece | Recruiting |
| Prodromos Stem Cell Institute Coordinator of this site? Confirm its status | Naples | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.