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Taking people in United StatesPhase 1

Tests stem cell exosomes given by nose for optic nerve damage

Tests stem cell exosomes given into the nose in people with non-arteritic ischemic optic neuropathy.

Plain-language title generated from the registry record
Registry title: Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Exosomes for NAION

Key facts

Where
Naples, United StatesSee the site
Phase
Phase 1

Where in United States

  • Prodromos Stem Cell InstituteNaples, United StatesTaking people

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  4. What happens if I want to stop?
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Trial details

Who runs it
The Foundation for Orthopaedics and Regenerative Medicine
Trial code
NCT05147701
Record updated
16 October 2026
Original description
This trial will study the safety and efficacy of intranasal delivery of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes for the treatment of non-arteritic ischemic optic neuropathyRead full original descriptionShow less

Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Exosomes for the Treatment of Non-arteritic Ischemic Optic Neuropathy

This trial will study the safety and efficacy of intranasal delivery of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes for the treatment of non-arteritic ischemic optic neuropathy

Inclusion: Diagnosis of NAION (non-arteritic ischemic optic neuropathy); Understanding and willingness to sign a written informed consent document.

Exclusion: Continued drug abuse; Previous organ transplant; Active infection; Active cancer; Chronic multisystem organ failure; Medical condition that would (based on the opinion of the investigator) compromise patient's safety; Hypersensitivity to sulfur; Clinically significant Abnormalities on pre-treatment laboratory evaluation; Pregnancy; Pre-menopausal women not using contraception.

ClinicalTrials.gov NCT05147701