Effects of Resistance Exercise on Blood Glucose in Post-menopausal Women With Type 1 Diabetes
Key facts
- Where
- Edmonton, CanadaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 45 and 75 years old?
Source: NCT05203640, who can take part
Where in Canada
- Alberta Diabetes InstituteEdmonton, CanadaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Alberta
- Trial code
- NCT05203640
- Record updated
- 8 July 2025
- Original description
Regular physical activity has substantial health benefits in people with type 1 diabetes. The fear of hypoglycemia, both during and after exercise, is a major barrier to exercise in this population. A major obstacle to providing specific physical activity and exercise advice is that there are still significant gaps in the fundamental understanding of the impact of physical activity and exercise on blood glucose levels in type 1 diabetes.Read full original descriptionShow less
Acute Glycemic Effects of Resistance Exercise in Post-menopausal Women With Type 1 Diabetes
Regular physical activity has substantial health benefits in people with type 1 diabetes. The fear of hypoglycemia, both during and after exercise, is a major barrier to exercise in this population. A major obstacle to providing specific physical activity and exercise advice is that there are still significant gaps in the fundamental understanding of the impact of physical activity and exercise on blood glucose levels in type 1 diabetes.
Women with type 1 diabetes have a substantial increase in cardiovascular risk once they have passed menopause. They may lose both bone quality and muscle mass at a faster rate with aging than those without diabetes. Overall, these changes greatly increase the risk of both cardiovascular and frailty related complications. Despite the many potential benefits of resistance exercise for post-menopausal women with type 1 diabetes, there are currently no published studies examining the effects of resistance exercise in this population. Before being able to design a clinical trial of resistance exercise, an examination of the acute effects of resistance exercise on blood glucose levels in post-menopausal women with type 1 diabetes is required.
The present study will compare the glycemic effects of a low resistance, high repetition (3 sets of 15 to 20 repetitions) weight lifting program to the effects of a moderate resistance, moderate repetition (3 sets of 8 to 10 repetitions). The investigators hypothesize that the high repetition program will be associated with a bigger decline in blood glucose during exercise, but that the moderate resistance program will be associated with a higher risk of post-exercise hypoglycemia.
Inclusion: female; type 1 diabetes diagnosed for at least 1 year; at least 12 months since last menstrual period; physically able and willing to perform resistance exercise; HbA1c < 10%; residing near Edmonton, Alberta / able to attend laboratory based sessions at the University of Alberta.
Exclusion: A history of cardiovascular disease; Individuals with HbA1c >9.9%; Individuals who are treated with medications (other than insulin) that affect glucose metabolism (e.g. atypical antipsychotics, corticosteroids); Frequent and unpredictable hypoglycaemia; A change in insulin management strategy within two months of the study; Blood pressure > 144/95,; Severe peripheral neuropathy,; Musculoskeletal injuries affecting the ability to perform resistance exercise; A body mass index >30kg/m2,; Smoking; Moderate to high alcohol intake (>2 drinks per day).