Studies heart hormone levels with exercise and sugar challenges in adults
Studies how exercise and a glucose drink affect heart hormone levels in adults.
Plain-language title generated from the registry record
Registry title: GENESIS: Genotype Guided - Natriuretic Peptides - Cardiometabolic Health Study
Key facts
- Where
- Birmingham, United StatesSee the site
Where in United States
- University of Alabama at BirminghamBirmingham, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Alabama at Birmingham
- Trial code
- NCT05216042
- Record updated
- 5 October 2026
- Original description
Natriuretic Peptides (NP) are hormones produced by the heart, and they have a wide range of favorable metabolic benefits. Lower levels of these hormones are associated with an increased likelihood of the development of diabetes and poor cardiometabolic health. Obese and Black individuals have ~30% lower levels of NP and are at a greater risk of developing cardiovascular (CV) events as compared to lean and White counterparts. Some people have common genetic variations that cause them to have ~20% lower NP levels. Similar to other low NP populations, these individuals with low NP genotype (i.e., carrying a common genetic variation called rs5068) are at a greater risk of developing cardiometabolic diseases. By understanding the NP response following the exercise challenge and the glucose challenge in individuals with genetically lower NP levels will help us understand how to improve cardiometabolic health in them.Read full original descriptionShow less
Atrial Natriuretic Peptide and Regulation of Cardiometabolic Health: A Genotype-Guided Human Physiological Study
Natriuretic Peptides (NP) are hormones produced by the heart, and they have a wide range of favorable metabolic benefits. Lower levels of these hormones are associated with an increased likelihood of the development of diabetes and poor cardiometabolic health. Obese and Black individuals have ~30% lower levels of NP and are at a greater risk of developing cardiovascular (CV) events as compared to lean and White counterparts. Some people have common genetic variations that cause them to have ~20% lower NP levels. Similar to other low NP populations, these individuals with low NP genotype (i.e., carrying a common genetic variation called rs5068) are at a greater risk of developing cardiometabolic diseases. By understanding the NP response following the exercise challenge and the glucose challenge in individuals with genetically lower NP levels will help us understand how to improve cardiometabolic health in them.
Inclusion: Adults: Age more than or equal to 18; an equal number of Males and Females; Consent to the collection of genetic material; Willing to adhere to the study protocol.
Exclusion: Participants who are taking more than 2 hypertension medications; Have any past or present history of cardiovascular diseases (stroke, seizure, myocardial infarction, heart failure, transient ischemic attack, angina, or cardiac arrhythmia); History of diabetes or fasting plasma glucose >126 mg/dl or HbA1C>=6.5% or prior treatment with antidiabetic medication; Estimated GFR < 60 ml/min/1.73 m2; albumin creatinine ratio ≥30 mg/g; Hepatic Transaminase (AST and ALT) levels >3x the upper limit of normal; Age <18, at screening; BMI >45 kg/m2; Blood pressure more than 140/90 mmHg; Women who are pregnant or breastfeeding or who can become pregnant and not practicing an acceptable method of birth control during the study (including abstinence); Anemia (men, Hct < 38%; women, Hct <36%); Inability to exercise on a treadmill.