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Studying Pain Processing in Fibromyalgia and Rheumatoid Arthritis

Observes how pain is processed in adults with fibromyalgia or rheumatoid arthritis.

Plain-language title generated from the registry record
Registry title: Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes

Key facts

Where
Gainesville, United StatesSee the site

Could this be for you?

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 18 and 70 years old?

Source: NCT05277025, who can take part

Where in United States

  • University of FloridaGainesville, United StatesTaking people

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?
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Trial details

Who runs it
University of Florida
Trial code
NCT05277025
Record updated
19 August 2026
Original description
Fibromyalgia (FM) is a chronic musculoskeletal pain disorder that afflicts up to 4% of the general population. The evaluation of pain mechanisms in FM has shown predominant central abnormalities and therefore has been designated as nociplastic pain syndrome. Rheumatoid arthritis (RA) is characterized by polyarthritis and pain from inflamed tissues, consistent with nociceptive pain. FM and RA patients may utilize overlapping pain mechanisms resulting in nociceptive and nociplastic pain.Read full original descriptionShow less

Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes

Fibromyalgia (FM) is a chronic musculoskeletal pain disorder that afflicts up to 4% of the general population. The evaluation of pain mechanisms in FM has shown predominant central abnormalities and therefore has been designated as nociplastic pain syndrome. Rheumatoid arthritis (RA) is characterized by polyarthritis and pain from inflamed tissues, consistent with nociceptive pain. FM and RA patients may utilize overlapping pain mechanisms resulting in nociceptive and nociplastic pain.

Inclusion: Ages 18-70; Fulfills the 1990 and 2011 American College of Rheumatology Criteria for FM; Fulfills the 2010 ACR-EULAR classification criteria for RA; Healthy volunteers: No significant pain/fatigue/depression/anxiety.

Exclusion: Diabetes; Cancer; Advanced liver, kidney or cardiovascular disease; Neuropathic pain.

ClinicalTrials.gov NCT05277025