Rheumatoid arthritis trials in United States

In United States 86 Also abroad 351

86 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 1/2Taking people
A Study of AZD0120 in Autoimmune Diseases
Where
Ann Arbor, Baltimore, Chapel Hill, Chicago, Duarte, Miami, New York, Seattle, Stanford, St Louis, Tucson
Age
18 years to 75 years
People
27 worldwide
Run by
AstraZeneca
See details and how to joinNCT07295847
Phase 2Taking people
Study of PTC844 in Participants With Active Rheumatoid Arthritis
Where
Chandler, Charlotte, Chicago, Cutler Bay, Fairfax, Flagstaff, Irving, Miami, New Port Richey, Phoenix, Westlake Village, Willow Grove, Winter Park
Age
18 years to 70 years
People
75 worldwide
Run by
PTC Therapeutics
See details and how to joinNCT07779616
No phaseTaking people
Effect of Anti-inflammatory Diet in Rheumatoid Arthritis
Where
La Jolla
Age
18 years and over
People
124
Run by
University of California, San Diego
See details and how to joinNCT04748809
No phaseTaking people
Pain Phenotyping of Rheumatic Diseases - An Observational Study
Where
Bethesda
Age
9 years to 85 years
People
225
Run by
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
See details and how to joinNCT07829497
No phaseTaking people
EMPHASYS Cup Positioning in THA With Non-Invasive Navigation (Velys Hip Navigation (VHN))
Where
Gainesville, Gastonia
Age
21 years and over
People
118
Run by
DePuy Orthopaedics
See details and how to joinNCT06631638
Phase 1/2Taking people
A Phase 1/2 Study of NKX019 in Subjects With Immune-Mediated Diseases (Ntrust-2)
Where
Ann Arbor, Charlotte, Dallas, Fairway, Hackensack, Los Angeles, Minneapolis, New York, Plantation, Summit, Syracuse, Tampa
Age
18 years to 75 years
People
240
Run by
Nkarta, Inc.
See details and how to joinNCT06733935
Phase 1Taking people
Study Evaluating Safety, Tolerability, PK/PD of Surovatamig in Adult RA or SLE Participants
Where
Allen, Birmingham, Fullerton, Mesquite, Plantation, St Louis
Age
18 years to 65 years
People
48 worldwide
Run by
AstraZeneca
See details and how to joinNCT07201558 · EU 2025-522273-10-00
No phaseTaking people
Collection of Airway, Blood and/or Urine Specimens From Subjects for Research Studies
Where
New York
Age
18 years and over
People
2,000
Run by
Weill Medical College of Cornell University
See details and how to joinNCT01776398
Phase 2Taking people
A Study to Assess the Safety and Efficacy of Different Doses of ELV001 to Treat Active Rheumatoid Arthritis in Patients With an Inadequate Response to Methotrexate and Tumor Necrosis Factor Inhibition (START SYNERGY)
Where
Baytown, Boca Raton, Charlotte, Denver, Duncansville, Gilbert, Glendale, Houston, Jackson, Lake Charles, Lansing, Margate, Miami, Miami Beach, Red Oak, South Miami, Tomball, Tucson, Tustin, Wilmington, Wyomissing
Age
18 years to 75 years
People
180 worldwide
Run by
Elevara Medicines Limited
See details and how to joinNCT07409103
Phase 1/2Taking people
A Study of BMS-986528 in Participants With Refractory Rheumatoid Arthritis
Where
Aurora, Denver, DeSoto, La Jolla, Loma Linda, New York, Palo Alto, Philadelphia, Portland, South Miami
Age
18 years to 65 years
People
84 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT07412704 · EU 2025-520666-22-00
No phaseTaking people
Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still's Disease, and Related Conditions
Where
Bethesda
Age
1 day to 100 years
People
2,000
Run by
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
See details and how to joinNCT03510442
No phaseTaking people
Observational Study of Pediatric Rheumatic Diseases: The CARRA Registry
Where
Akron, Albany, Ann Arbor, Atlanta, Augusta, Aurora, Birmingham, Boston, Burlington, Chapel Hill, Charleston, Charlotte, Chicago, Cincinnati, Cleveland, Columbus, Dallas, Durham, Fargo, Gainesville, Grand Rapids, Hackensack, Hartford, Hershey, Houston, Indianapolis, Iowa City, Jackson, Kansas City, Lake Success, Los Angeles, Louisville, Madison, Miami, Minneapolis, Morristown, Nashville, New Brunswick, New Haven, New York, Norfolk, Orlando, Palo Alto, Philadelphia, Phoenix, Pittsburgh, Portland, Providence, Rochester, Salt Lake City, San Diego, San Francisco, Seattle, Springfield, St Louis, St. Petersburg, Washington D.C., Wauwatosa, West Orange, Winston-Salem
Age
Up to 21 years
People
20,000 worldwide
Run by
Duke University
See details and how to joinNCT02418442
Phase 1Taking people
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Intravenous Infusion and Intra-Articular Injection for RA
Where
Naples
People
20 worldwide
Run by
The Foundation for Orthopaedics and Regenerative Medicine
See details and how to joinNCT05003934
Phase 1Taking people
A Study to Assess Adverse Events, How the Drug Moves Through the Body and Effectiveness of Intravenous Infusions and Subcutaneous Injections of ABBV-519 in Adult Participants With Systemic Lupus Erythematosus (SLE) or Rheumatoid Arthritis (RA)
Where
Anniston, Clearwater, Greenacres City, Houston, Jackson, Kissimmee, Miami, Orland Park, Plantation, Red Oak, Tampa, Tustin
Age
18 years to 75 years
People
30 worldwide
Run by
AbbVie
See details and how to joinNCT07607964
Phase 1Taking people
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.
Where
Anniston, Birmingham, Chapel Hill, Iowa City, La Jolla, Omaha, Sacramento
Age
18 years to 70 years
People
72 worldwide
Run by
AstraZeneca
See details and how to joinNCT06916806 · EU 2024-519015-34-00
Phase 2Taking people
A Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Rheumatoid Arthritis Who Have Not Responded to or Who Cannot Tolerate Tumor Necrosis Factor (TNF) and/or Janus Kinase (JAK Inhibitors)
Where
Avondale, Chesapeake, Colleyville, Columbus, Detroit, Duncansville, Glendale, Houston, La Jolla, Lake Charles, Los Angeles, Owensboro, Peoria, Tamarac, The Bronx, Tomball, Upland, Willowbrook
Age
18 years and over
People
160 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT07137598
Phase 2Taking people
An Extension Study to Assess Long-Term Safety and Efficacy of Afimkibart in Participants With Rheumatoid Arthritis
Where
Glendale, Houston, Lake Charles, Tamarac, Tomball
Age
18 years and over
People
120 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT07620392 · EU 2025-523579-47-00
No phaseTaking people
HRV Variation in Rheumatoid Arthritis
Where
Orlando
Age
18 years and over
People
30
Run by
University of Central Florida
See details and how to joinNCT07878975
No phaseNot yet taking people in United States
Patient-Reported Outcomes Dashboard With Goal Setting to Support Shared Decision-Making in Inflammatory Arthritis
Where
Chicago
Age
18 years and over
People
160
Run by
Northwestern University
See details and how to joinNCT07865390
Phase 1Not yet taking people in United States
A Study of BMS-986553 in Participants With Refractory Autoimmune Diseases
Where
Ann Arbor, Great Neck, Morristown, Newport Beach, Omaha, Philadelphia, Saint Paul, Salt Lake City, Seattle, Worcester
Age
18 years and over
People
60 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT07873931
Phase 1/2Taking people
Phase 1b/2 Study of IV Sarilumab in Adult With RA
Where
Centennial, Clearwater, Duncansville, El Paso, Hialeah, Hollywood, Houston, Mesquite, Miami, Plano, Plantation, Weston
Age
18 years and over
People
140
Run by
Sanofi
See details and how to joinNCT07704580
Phase 2Taking people
A Study to Investigate Efficacy and Safety of AZD1163 in Participants With Rheumatoid Arthritis
Where
Aurora, Austin, Baltimore, Baytown, Boynton Beach, Glendale, Henderson, Houston, Jacksonville, Kansas City, La Jolla, Lake Charles, Marietta, Mesquite, Myrtle Beach, New Bedford, Prescott Valley, Rockville, San Dimas, San Leandro, Skokie, South Miami, St Louis, Tampa, Tomball, Tucson, Willowbrook, Winter Haven
Age
18 years and over
People
320 worldwide
Run by
AstraZeneca
See details and how to joinNCT07276581
Phase 2Taking people
A Study to Evaluate Different Targeted Therapies for Patients With Rheumatoid Arthritis
Where
Albuquerque, Austin, Avon Park, Beverly Hills, Carrollton, Charlotte, Chicago, Chula Vista, Clearwater, Corpus Christi, Duncansville, Fort Collins, Frisco, Grand Blanc, Great Neck, Greenacres City, Hialeah, Hollywood, Houston, Huntington Beach, Jackson, Jacksonville, Jonesboro, Katy, Lake Charles, Libertyville, Margate, Mesquite, Middleburg Heights, Orlando, Orland Park, Palm Beach Gardens, Peoria, Plano, Red Oak, Skokie, Sugar Land, Summerville, Tampa, Thousand Oaks, Tomball, Torrance, Upland, West Long Branch, Willowbrook
Age
18 years and over
People
180 worldwide
Run by
AbbVie
See details and how to joinNCT06972446 · EU 2025-520721-21-00
Phase 1Taking people
Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO
Where
Atlanta, Baltimore, Bethesda, Birmingham, Boston, Chicago, City of Saint Peters, Columbus, Creve Coeur, Dallas, Detroit, Fairway, Fort Worth, Hays, Houston, Kansas City, Lawrence, Lee's Summit, Lexington, Mineola, New Brunswick, New Haven, New York, North Kansas City, Olathe, Overland Park, Palo Alto, Philadelphia, Pittsburg, Pittsburgh, Richardson, Richmond, Sacramento, Salina, Salt Lake City, St Louis, Topeka, Washington D.C., Westwood
Age
18 years and over
People
300 worldwide
Run by
National Cancer Institute (NCI)
See details and how to joinNCT03816345
Phase 2Taking people
A Phase 2 Master Protocol Assessing Inebilizumab and Blinatumomab in Autoimmune Diseases
Where
Aurora, Boston, Cleveland, Great Neck, Hawthorne, Hialeah, Homestead, Houston, Miami, New Orleans, New York, Rochester, Scottsdale, Seattle, South Miami
Age
18 years to 75 years
People
220 worldwide
Run by
Amgen
See details and how to joinNCT06570798