Growing Intestinal Mini-Organs From Patient Biopsies
Studies intestinal mini-organs grown from biopsies of adults with bowel disease.
Plain-language title generated from the registry record
Registry title: Intestinal Organoids
Key facts
- Where
- Rennes, FranceSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Source: NCT05294107, who can take part
Where in France
- CHU de RENNES-Service des Maladies de l'Appareil DigestifRennes, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Rennes University Hospital
- Trial code
- NCT05294107
- Record updated
- 17 June 2026
- Original description
Over the last decade, the use of mini-organ or organoids has been increasingly developed in fundamental research. Indeed, digestive organoids represent an essential advance compared to classical culture systems (epithelial cell lines, immortalized cells) since they preserve in culture the functional complexity present in vivo (architecture, different cell types). They also have the advantage of being able to be propagated indefinitely (unlike explants), minimizing the use of animal models and reducing the amount of tissue required. Finally, their growth and development depends on the origin of the sample (the organoid will develop differently if the cell source comes from a patient suffering from an inflammatory bowel disease, for example), thus generating models of human pathologies to better determine their physiopathology. The use of organoids in biomedical research has proven to be an indispensable tool for the understanding of cellular and molecular mechanisms involved in epithelial renewal and the screening of molecules and ingredients for applications in the health and agri-food sectors.Read full original descriptionShow less
Intestinal Organoids
Over the last decade, the use of mini-organ or organoids has been increasingly developed in fundamental research. Indeed, digestive organoids represent an essential advance compared to classical culture systems (epithelial cell lines, immortalized cells) since they preserve in culture the functional complexity present in vivo (architecture, different cell types). They also have the advantage of being able to be propagated indefinitely (unlike explants), minimizing the use of animal models and reducing the amount of tissue required. Finally, their growth and development depends on the origin of the sample (the organoid will develop differently if the cell source comes from a patient suffering from an inflammatory bowel disease, for example), thus generating models of human pathologies to better determine their physiopathology. The use of organoids in biomedical research has proven to be an indispensable tool for the understanding of cellular and molecular mechanisms involved in epithelial renewal and the screening of molecules and ingredients for applications in the health and agri-food sectors.
Inclusion: Subjects aged 18 to 75 years; Subject undergoing endoscopy as part of the standard of care with the need to take digestive biopsy samples; Subject having signed a free and informed consent in writing.
Exclusion: Anticoagulant treatment and anti-platelet treatment (except for aspirin 75 mg); Subjects under legal protection (safeguard of justice, curatorship or guardianship) or deprived of liberty.