Studies whether breathing patterns in preterm babies relate to later asthma, sleep and development
Follows preterm children to see whether breathing dips in the NICU predict later health problems.
Plain-language title generated from the registry record
Registry title: Post-Vent, the Sequelae: Personalized Prognostic Modeling for Consequences of Neonatal Intermittent Hypoxemia in Preterm Infants at Pre-School Age
Key facts
- Where
- Chicago, United StatesSee the site
Where in United States
- Ann & Robert H. Lurie Children's Hospital of ChicagoChicago, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Ann & Robert H Lurie Children's Hospital of Chicago
- Trial code
- NCT05336890
- Record updated
- 15 September 2026
- Original description
Despite improved survival of extremely premature infants in recent decades, neonatal intensive care unit (NICU) graduates are diagnosed with asthma, sleep disordered breathing (SDB) in childhood, and neurodevelopmental impairments (NDI) at significant rates, disproportionate to their term peers. Early detection and intervention are critical to mitigate the impact of these impairments. Mechanisms leading from premature birth to these undesirable outcomes remain unclear, and accurate prognostic measures are lacking.Read full original descriptionShow less
Post-Vent, the Sequelae: Personalized Prognostic Modeling for Consequences of Neonatal Intermittent Hypoxemia in Preterm Infants at Pre-School Age
Despite improved survival of extremely premature infants in recent decades, neonatal intensive care unit (NICU) graduates are diagnosed with asthma, sleep disordered breathing (SDB) in childhood, and neurodevelopmental impairments (NDI) at significant rates, disproportionate to their term peers. Early detection and intervention are critical to mitigate the impact of these impairments. Mechanisms leading from premature birth to these undesirable outcomes remain unclear, and accurate prognostic measures are lacking.
This study wants to learn if these problems are related to certain patterns of breathing that babies had while they were in the NICU.
Inclusion: Enrolled in any Institutional Review Board (IRB) protocol of the Pre-Vent Study that had signed consent, or in any IRB protocol of the Pre-Vent Study that authorized re-contact for future research; Born <29 weeks gestational age; Age at enrollment less than 7 years old.
Exclusion: Parent refused further contact, prior to approach for Post-Vent; Subject was withdrawn from the Pre-Vent study after signing Pre-Vent consent form, for any reason; Subject had no physiological data recorded as part of Pre-Vent; Lack of regulatory approval from local IRB or Department of Children and Family Services (DCFS) to recontact subjects; Adopted by non-consenting family; Infant enrolled in Pre-Vent at Washington University St Louis, which is not a Post-Vent participating site.