Modeling Blood Pressure in the Liver During Liver Surgery
Tests a computer model predicting liver blood pressure in adults having liver surgery.
Plain-language title generated from the registry record
Registry title: Hepatic and Systemic Hemodynamic Modeling During Liver Surgery
Key facts
- Where
- Villejuif, FranceSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with a liver disease who need liver surgery: a partial liver removal, a transplant with a small or partial liver, or a procedure that blocks a branch of the portal vein before surgery.
- Age
- 18 years or older
- Sex
- Men and women can join
- Disease stage
- Liver disease that needs a minor or major liver removal by open surgery, a transplant with a small or partial liver, or portal vein embolization. For cirrhosis, major liver removal. For a liver without cirrhosis, extended liver removal only if the future remaining liver/body weight ratio is <0.5.
Main reasons for not taking part
- Pregnant or breastfeeding women
- Patients under guardianship or curatorship
- Patients who cannot have an MRI
- Patients under State medical aid
- Patients who refuse to take part
Read by machine on 12 November 2026.
Where in France
- Centre Hépato-Biliaire - Hôpital Paul BrousseVillejuif, FranceContact: Nicolas GOLSE, phDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Assistance Publique - Hôpitaux de Paris
- Trial code
- NCT05339984
- Record updated
- 27 June 2025
- Original description
" Despite the medical and surgical progress of the last two decades, the selection of candidates for liver surgery remains based on old principles and insufficiently sensitive to fine-tune the gesture to patient-specific characteristics and make almost zero risks of postoperative liver failure (PLF) and death. It is therefore necessary to develop new tools that will make possible to predict the evolution of the postoperative portocaval gradient (difference of pressure between portal vein and vena cava), a well-known major risk factor for PLF. Hemodynamic modeling of the human liver during surgery will represent the purpose of this work in order to help the clinicians in their patient's selection and anticipation of postoperative risk.Read full original descriptionShow less
Hepatic and Systemic Hemodynamic Modeling During Liver Surgery
" Despite the medical and surgical progress of the last two decades, the selection of candidates for liver surgery remains based on old principles and insufficiently sensitive to fine-tune the gesture to patient-specific characteristics and make almost zero risks of postoperative liver failure (PLF) and death. It is therefore necessary to develop new tools that will make possible to predict the evolution of the postoperative portocaval gradient (difference of pressure between portal vein and vena cava), a well-known major risk factor for PLF. Hemodynamic modeling of the human liver during surgery will represent the purpose of this work in order to help the clinicians in their patient's selection and anticipation of postoperative risk.
The aim is to develop and validate an hemodynamics mathematical model to predict the evolution of the portocaval gradient in three surgical situations of increasing complexity: portal modulation by embolization, hepatectomy, and small partial graft liver transplantation.
The endpoints will be the estimation of the intraoperative post-procedural portocaval gradient and comparison of the estimated portocaval gradient with that measured at the end of the procedure. This pressure differential is performed before parietal closure, after surgery. "
Inclusion: Liver pathology requiring minor or major hepatectomy by laparotomy, or transplantation with small livers (graft weight/patient weight ratio < 0. 01) or partial livers (living donor recipient or auxiliary grafts) or portal embolization (all patients scheduled for major hepatectomy on cirrhosis, or expanded hepatectomy on non-cirrhotic liver if and only if the ratio of future remaining liver/body weight is <0.5; Membership in a social security plan; Written consent to participate in this research; Adult patients (age ≥18 years).
Exclusion: Pregnant or breastfeeding women; Patient under guardianship or curatorship; Refusal to participate in the study; Contraindication to performing of MRI; Patient Under State medical aid.