Imaging the Retina With Adaptive Optics in Outer Retinal Diseases
Uses adaptive optics eye imaging to study outer retinal diseases in adults.
Plain-language title generated from the registry record
Registry title: Adaptive Optics Imaging of Outer Retinal Diseases
Key facts
- Where
- Bethesda and Silver Spring, United StatesSee the 2 sites
Where in United States
- NIH Clinical CenterBethesda, United StatesTaking people
- Food and Drug AdministrationSilver Spring, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Food and Drug Administration (FDA)
- Trial code
- NCT05355415
- Record updated
- 8 May 2026
- Original description
The objective of the study is to collect adaptive optics (AO) retinal images from human subjects with outer retinal diseases (diseases of the outer retina including photoreceptor, retinal pigment epithelium (RPE), basement membrane or choroidal pathologies) to develop new diagnostic methods, biomarkers, and clinical endpoints.Read full original descriptionShow less
Adaptive Optics Imaging of Outer Retinal Diseases
The objective of the study is to collect adaptive optics (AO) retinal images from human subjects with outer retinal diseases (diseases of the outer retina including photoreceptor, retinal pigment epithelium (RPE), basement membrane or choroidal pathologies) to develop new diagnostic methods, biomarkers, and clinical endpoints.
Inclusion: Are 21 years of age or older,; Have the ability to cooperate with instructions during adaptive optics imaging (similar to instructions given during a clinical eye exam),; Have the ability to understand and sign an informed consent. (Non-English speaking participants will not be enrolled into the study), and; Have been diagnosed with outer retinal disease or condition (Cohort 2).
Exclusion: Have a condition which prevents adequate images from being obtained (e.g. unstable fixation or media opacity),; Have a history of adverse reaction to mydriatic drops,; Have a predisposition to (i.e., narrow iridocorneal angle) or any history of acute angle closure glaucoma (AACG), or; Have visual correction outside of the range +4 diopters (D) to -8 D,; Are working under the direct supervision of Drs. Hammer, Cukras and Liu, or any of the NIH/NEI AIs.